Herbicidal acetals and ketals

ABSTRACT

Novel furan- and thiophenesulfonamides such as 3-(1,3-dioxolan-2-yl)-N-[(4-methoxy-6-methyl-1,3-5-triazin-2-yl)aminocarbonyl]-2-thiophenesulfonamide and N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3-(1,3-dioxolan-2-yl)-2-thiophenesulfonamide are highly active pre-emergent and/or post-emergent herbicides.

CROSS REFERENCE TO RELATED APPLICATIONS

This application is a continuation-in-part of copending application U.S.Ser. No. 644,259 filed Aug. 27, 1984, now abandoned.

BACKGROUND OF THE INVENTION

The present invention relates to a novel class of furan- andthiophenesulfonamide compounds and their use as pre-emergent andpost-emergent herbicides and as plant growth regulants.

U.S. Pat. Nos. 4,169,719 and 4,127,405 disclose herbicidal benzene-,furan- and thiophenesulfonamides of general formula ##STR1## where R₁may be an optionally substituted benzene or a furan or thiophenesubstituted with H, Cl, Br or CH₃.

U.S. Pat. No. 4,398,939 discloses herbicidal thiophenesulfonamides offormula ##STR2## where R is C₁ -C₄ alkyl, C₃ alkenyl, OCH₃, NO₂, Cl, Br,SO₂ NR₁ R₂ or SO₂ N(OCH₃)CH₃.

European Patent Application (EP-A) No. 30,142, published 6/10/81discloses herbicidal furan- and thiophenesulfonamides of formula##STR3## where W' is O or S;

A is C(O)QR^(I) or C(═T)R^(II) ; and

A' is H, Cl, Br, C₁ -C₄ alkyl, OCH₃, NO₂ or CF₃.

U.S. Pat. No. 4,370,480 teaches herbicidal benzenesulfonamides ofgeneral formula ##STR4##

No. EP-A-64,804, published 11/17/82, teaches herbicidal furan- andthiophenesulfonamides of general formula ##STR5## where R₁ is S(O)_(n)R₆ ; and

R₂ is H, Cl, Br or CH₃ ;

No. EP-A-13,480 discloses herbicidal pyridinesulfonamides of formula##STR6## where R₁ is H, Cl, Br, F, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄alkylthio, NO₂ or CO₂ R₅ ; and

R₂ is H, Cl, Br or CH₃.

No. EP-A-35,893 discloses herbicidal pyridinesulfonamides of formula##STR7## where R₁ is S(O)_(n) R₃ ; and

R₂ is H, Cl, F, Br, CH₃, OCH₃, CF₃, NO₂, CN or NH₂.

No. EP-A-97,122, published Dec. 28, 1983, discloses herbicidalsulfonamides of formula ##STR8## where X is O, S, NR₄ or CR₅ ═N; and

R₂ is H, C₁ -C₃ alkyl, haloalkyl, alkoxy, alkylthio, alkylsulfonyl,halogen, NO₂, CWR₈, SO₂ NR₆ R₇ or COR₉.

No. EP-A-95,925, published Dec. 7, 1983, and No. EP-A-87,780, publishedSept. 7, 1983, teach herbicidal pyrazole sulfonylureas.

No. EP-A-95,925 (published Dec. 7, 1983) and No. EP-A-87,780 (publishedSept. 7, 1983) teach herbicidal pyrazole sulfonylureas.

No. EP-A-126,711 (published 11/28/84; Swiss priority 5/16/83) disclosesherbicidal sulfonylureas of the formula ##STR9## wherein X is O, S,--NR₅, ##STR10## --CH═CH-- or an annelated phenyl ring; Z is O or S;

Q is halogen, C₁ -C₄ alkyl, cyano, etc.;

R₁ is H, halogen, NO₂ or a group ##STR11## etc.; R₆ is, inter alia, H orC₁ -C₄ alkyl; and R₂ and R₃ can be, among other things, C₁ -C₄ alkyl orC₁ -C₄ alkoxy.

SUMMARY OF THE INVENTION

This invention relates to novel compounds of Formula I, agriculturallysuitable compositions containing them and their method-of-use aspreemergent and/or postemergent herbicides or plant growth regulants.##STR12## wherein ##STR13## R is H or CH₃ ; R₁ is ##STR14## E is CH₂ ora single bond; R₂ is H, C₁ -C₂ alkyl or Cl;

R₃ is H, C₁ -C₃ alkyl or C₁ -C₃ alkoxy;

R₄ and R₅ are independently C₁ -C₂ alkyl;

R₆ and R₇ are independently H or C₁ -C₂ alkyl;

W is O or S;

W₁ is O or S;

Q₁ and Q₂ are independently O, S or NCH₃ ;

A is ##STR15## X is H, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄ haloalkoxy,C₁ -C₄ haloalkyl, C₁ -C₄ haloalkylthio, C₁ -C₄ alkylthio, halogen, C₂-C₅ alkoxyalkoxy, amino, C₁ -C₃ alkylamino or di(C₁ -C₃)alkylamino;

Y is H, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄ haloalkoxy, C₁ -C₄haloalkylthio, C₁ -C₄ alkylthio, halogen, C₂ -C₅ alkoxyalkyl, C₂ -C₅alkoxyalkoxy, amino, C₁ -C₃ alkylamino, di(C₁ -C₃)alkylamino, C₃ -C₄alkenyloxy, C₃ -C₄ alkynyloxy, C₂ -C₅ alkylsulfinylalkyl, C₁ -C₄haloalkyl, C₂ -C₅ alkylsulfonylalkyl, C₃ -C₅ cycloalkyl, C₂ -C₄ alkynyl,C₂ -C₅ alkylthioalkyl, C(O)R₈, ##STR16## N(OCH₃)CH₃ ; m is 2 or 3;

L₁ and L₂ are independently O or S;

R₈ is H or CH₃ ;

R₉ and R₁₀ are independently C₁ -C₂ alkyl;

R₁₁ is C₁ -C₃ alkyl;

R₁₂ is H, F, Cl, NO₂, C₁ -C₂ alkyl, C₁ -C₂ alkoxy, C₁ -C₂ alkylthio, C₁-C₂ alkylsulfinyl, C₁ -C₂ alkylsulfonyl, di(C₁ -C₂)alkylsulfamoyl or CO₂(C₁ -C₂ alkyl);

R₁₃ is H, C₁ -C₂ alkyl, C₁ -C₂ alkoxy, Cl, F or NO₂ ;

R₁₄ is H, C₁ -C₃ alkyl, C₁ -C₃ alkoxy, C₁ -C₃ haloalkyl, C₁ -C₃haloalkoxy, Cl, Br, F, NO₂, di(C₁ -C₃)alkylsulfamoyl, C₁ -C₃ alkylthio,C₁ -C₃ alkylsulfinyl, C₁ -C₃ alkylsulfonyl, amino, C₁ -C₃ alkylamino,di(C₁ -C₃)alkylamino, CH₂ OCH₃, CH₂ SCH₃ or CH₂ CN.

Z is CH or N;

Y₁ is O or CH₂ ;

X₁ is CH₃, OCH₃, OC₂ H₅ or OCF₂ H; and

Y₂ is H or CH₃ ;

X₂ is CH₃, C₂ H₅ or CH₂ CF₃ ;

Y₃ is OCH₃, OC₂ H₅, SCH₃, SC₂ H₅, OCF₂ H, SCF₂ H, CH₃ or C₂ H₅ ;

X₃ is CH₃ or OCH₃ ;

Y₄ is CH₃, OCH₃, OC₂ H₅ or Cl; and

X₄ is CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃ or Cl;

and their agriculturally suitable salts; provided that

(a) when X is Cl, F, Br or I, then Z is CH and Y is OCH₃, OC₂ H₅,N(OCH₃)CH₃, NHCH₃, N(CH₃)₂ or OCF₂ H;

(b) when Y is cyclopropyl, X is other than Cl, F, Br or I;

(c) when R₃ is C₁ -C₃ alkoxy, then Q₁ and Q₂ are oxygen;

(d) when R₃ is H or C₁ -C₃ alkyl, then Q is Q-1 through Q-9;

(e) when X or Y is OCF₂ H, then Z is CH;

(f) when the total number of carbon atoms of X and Y is greater thanfour, then the combined number of carbons of the substituents on Q isless than or equal to ten;

(g) when W is S, then A is A-1, R is H, and Y is CH₃, OCH₃, OC₂ H₅, CH₂OCH₃, C₂ H₅, CF₃, SCH₃, OCH₂ CH═CH₂, OCH₂ C.tbd.CH, OCH₂ CH₂ OCH₃,CH(OCH₃)₂ or ##STR17## (h) when A is A-7 and Z is N, then R₃ is C₁ -C₃alkoxy; (i) when E is CH₂, then R₁₄ is H, CH₃, OCH₃, Cl or NO₂ and isnot in the 4-position.

In the above definitions, the term "alkyl" used either alone or incompound words such as "alkylthio" or "haloalkyl", denotes straightchain or branched alkyl, e.g., methyl, ethyl, n-propyl, isopropyl or thedifferent butyl isomers.

Alkoxy denotes methoxy, ethoxy, n-propoxy, isopropoxy and the differentbutoxy isomers.

Alkenyl denotes straight chain or branched alkenes, e.g., 1-propenyl,2-propenyl, 3-propenyl and the different butenyl isomers.

Alkynyl denotes straight chain or branched alkynes, e.g., ethynyl,1-propynyl, 2-propynyl and the different butynyl isomers.

Cycloalkyl denotes cyclopropyl, cyclobutyl and cyclopentyl.

The term "halogen", either alone or in compound words such as"haloalkyl", denotes fluorine, chlorine, bromine or iodine.

In terms such as C₂ -C₅ alkoxyalkoxy, the specified number of carbonatoms is meant to define the total number of carbon atoms in thatsubstituent group. For example, C₂ -C₅ alkoxyalkoxy would represent OCH₂OCH₃ through O(CH₂)₄ OCH₃ or OCH₂ O(CH₂)₃ CH₃ and the various structuralisomers embraced therein.

Alkylsulfonyl denotes methylsulfonyl, ethylsulfonyl and the differentpropylsulfonyl isomers.

Alkylthio, alkylsulfinyl, alkylamino, alkylsulfamoyl, etc., are definedin an analogous manner.

Preferred Compounds

Preferred for reasons of their higher herbicidal efficacy, greater plantgrowth regulant activity and/or more favorable ease of synthesis are:

(1) Compounds of Formula I where R₃ is H or C₁ -C₃ alkyl;

(2) Compounds of Formula I where R₃ is C₁ -C₃ alkoxy;

(3) Compounds of Preferred 1 where

W is O;

R is H;

X is CH₃, OCH₃, OC₂ H₅, Cl, F, Br, I, OCF₂ H, CH₂ F, OCH₂ CH₂ F, OCH₂CHF₂, OCH₂ CF₃ or CF₃ ; and

Y is H, C₁ -C₃ alkyl, OCH₃, OC₂ H₅, CH₂ OCH₃, NHCH₃, N(OCH₃)CH₃,N(CH₃)₂, CF₃, SCH₃, OCH₂ CH═CH₂, OCH₂ C.tbd.CH, OCH₂ CH₂ OCH₃, CH₂ SCH₃,CH₂ OC₂ H₅, ##STR18## OCF₂ H, C.tbd.CH, C.tbd.CCH₃, SCF₂ H orcyclopropyl; (4) Compounds of Preferred 3 where

Q₁ and Q₂ are identical and are O or S;

R₁₂ is H, C₁ -C₂ alkyl or Cl;

R₁₃ is H; and

(5) Compounds of Preferred 4 where

A is A-1;

Y is CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃, C₂ H₅, NHCH₃, CH₂ OC₂ H₅, OCF₂ H, OCH₂CH₂ OCH₃, cyclopropyl, C.tbd.CH or CH(OCH₃)₂ ; and

X is CH₃, OCH₃, Cl, OC₂ H₅, OCF₂ H or OCH₂ CF₃ ;

(6) Compounds of Preferred 5 where Q₁ and Q₂ are O;

(7) Compounds of Preferred 5 where Q₁ and Q₂ are S;

(8) Compounds of Preferred 5 where Q is Q-1;

(9) Compounds of Preferred 5 where Q is Q-2;

(10) Compounds of Preferred 5 where Q is Q-3;

(11) Compounds of Preferred 5 where Q is Q-4;

(12) Compounds of Preferred 5 where Q is Q-5;

(13) Compounds of Preferred 5 where Q is Q-6;

(14) Compounds of Preferred 5 where Q is Q-7;

(15) Compounds of Preferred 5 where Q is Q-8;

(16) Compounds of Preferred 5 where Q is Q-9;

(17) Compounds of Preferred 2 where

W is O;

R is H;

X is CH₃, OCH₃, OC₂ H₅, Cl, F, Br, I, OCF₂ H, CH₂ F, OCH₂ CH₂ F, OCH₂CHF₂, OCH₂ CF₃ or CF₃ ; and

Y is H, C₁ -C₃ alkyl, OCH₃, OC₂ H₅, CH₂ OCH₃, NHCH₃, N(OCH₃)CH₃,N(CH₃)₂, CF₃, SCH₃, OCH₂ CH═CH₂, OCH₂ C.tbd.CH, OCH₂ CH₂ OCH₃, CH₂ SCH₃,CH₂ OC₂ H₅, ##STR19## OCF₂ H, SCF₂ H, cyclopropyl, C.tbd.CH orC.tbd.CCH₃ ; (18) Compounds of Preferred 17 where

E is a single bond;

R₁₂ is H, C₁ -C₂ alkyl or Cl;

R₁₃ is H; and

R₁₄ is H, F, Cl, Br, C₁ -C₂ alkyl, C₁ -C₂ alkoxy or C₁ -C₂ alkylthio andis not para to the sulfonylurea bridge;

(19) Compounds of Preferred 18 where

A is A-1;

Y is CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃, C₂ H₅, NHCH₃,

CH₂ OC₂ H₅, OCF₂ H, OCH₂ CH₂ OCH₃, cyclopropyl, C.tbd.CH or CH(OCH₃)₂ ;and

X is CH₃, OCH₃, Cl, OC₂ H₅, OCF₂ H or OCH₂ CF₃ ;

(20) Compounds of Preferred 19 where Q is Q-1;

(21) Compounds of Preferred 19 where Q is Q-2;

(22) Compounds of Preferred 19 where Q is Q-3;

(23) Compounds of Preferred 19 where Q is Q-4;

(24) Compounds of Preferred 19 where Q is Q-5;

(25) Compounds of Preferred 19 where Q is Q-6;

(26) Compounds of Preferred 19 where Q is Q-7;

(27) Compounds of Preferred 19 where Q is Q-8;

(28) Compounds of Preferred 19 where Q is Q-9;

(29) Compounds of Preferred 19 where Q is Q-10;

Specifically Preferred for reasons of highest herbicidal efficacy and/ormost favorable ease of synthesis are:

3-(1,3-dioxolan-2-yl)-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]-2-thiophenesulfonamide,m.p. 164°-166° C.; and

N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3-(1,3-dioxolan-2-yl)-2-thiophenesulfonamide,m.p. 137°-150° C.

DETAILED DESCRIPTION OF THE INVENTION Synthesis

The compounds of Formula I can be prepared by one or more of the methodsshown in Equations 1-7.

As shown in Equation 1, compounds of Formula I (where W is O) can beprepared by treating sulfonamides of Formula II with phenyl esters ofN-heterocycliccarbamic acids of Formula III in the presence of a strongorganic base such as 1,8-diazabicyclo[5.4.0]-undec-7-ene (DBU).##STR20## wherein Q, R and A are as previously defined. The reaction ofEquation 1 is generally carried out in the range of 0° to 50° C. in aninert solvent such as dioxane or acetonitrile, analogous to methodstaught in No. EP-A-44,807. The required carbamates can be prepared fromthe corresponding amines, IIIa, and diphenyl carbonate orphenylchloroformate and a base such as sodium hydride as shown inEquation 2. ##STR21##

Compounds of Formula I may also be prepared as shown in Equation 3 bytreating sulfonamides of Formula II with the methyl ester of anN-heterocycliccarbamic acid of Formula IIIb in the presence of anequimolar quantity of trimethylaluminum. ##STR22##

The reaction of Equation 3 is best carried out at temperatures between25° and 83° C. in a solvent such as methylene chloride or1,2-dichloroethane for 12 to 95 hours under an inert atmosphere, astaught in No. EP-A-84,244, published July 27, 1983. The methylcarbamates, IIIb, can be conveniently sythesized by treatment of thecorresponding heterocyclic amines of Formula IIIa with dimethylcarbonate or methyl chloroformate in the presence of a base such assodium hydride.

Alternatively, compounds of Formula I can be prepared by the reaction ofa sulfonylcarbamate of Formula IV with an aminoheterocycle of FormulaIIIa as shown in Equation 4. ##STR23##

The reaction is carried out at 50° to 100° C. in a solvent such asdioxane for 0.5 to 24 hours as taught in No. EP-A-44,807. The requiredcarbamates of Formula IV are prepared by the reaction of thecorresponding sulfonamides of Formula II with diphenylcarbonate orphenylchloroformate in the presence of a base such as sodium hydride.

Compounds of Formula I, where W is S, can be prepared via addition of anappropriate heterocyclic amine, IIIa, to a sulfonyl isothiocyanate ofthe formula QSO₂ NCS. This reaction is best carried out according tomethods taught in U.S. Pat. No. 4,127,405.

Sulfonyl isothiocyanates of the formula QSO₂ NCS can be preparedaccording to the procedure of K. Hartke, Arch. Pharm., 299, 174 (1966).

Sulfonamides of Formula II used in the preparation of compounds ofFormula I are useful intermediates. They can be prepared by a variety ofmethods known in the art. For example, contacting an appropriatelysubstituted sulfonyl chloride IIa with ammonium hydroxide or ammonia inan inert solvent such as ether or tetrahydrofuran affords sulfonamidesII as shown by Equation 5a and 5b. ##STR24##

The reaction of sulfonyl chlorides, IIa, with ammonia is best carriedout at -33° to 50° C. for 0.1 to 24 hours. After removal of the ammoniumchloride by-product by filtration or extraction with water, the desiredproduct can be isolated by the evaporation of the organic solvent.

Ammonium hydroxide can be used in place of ammonia as in Equation 5b.This reaction is widely reported in the literature, c.f., Methoden DerOrganischen Chemie (Houben-Weyl), Vol. 9, Ch. 19, edited by F. Muth,Stuttgart, 1955.

Alternatively, sulfonamides of Formula II can be prepared by thereaction of a lithium salt of an appropriately substituted sulfinicacid, IIb, with chloramine as shown in Equation 6. ##STR25##

This reaction can be carried out using the conditions referred to in thepreceding reference.

Lithium salts of Formula IIb can also be converted to the sulfonamidesof Formula IIa by the procedures taught in U.S. Pat. No. 4,441,910.

Sulfonyl chlorides of Formula IIa can be prepared by the reaction oflithium salts of Formula IIc with sulfuryl chloride at -50° to -20° C.in an inert solvent such as tetrahydrofuran or ether as shown inEquation 7. ##STR26##

Where R' is a group such as butyl, phenyl, diisopropylamino or similarmoiety commonly combined with lithium to form a lithiation agent. Theseagents and their method of use are described in N. S. Narasimhan and R.S. Mali, Synthesis, 957-86 (1983) or the The Chemistry of OrganolithiumCompounds, Wakefield, Pergamon Press, Oxford, 1974 or also H. W.Gschwend and H. R. Rodriguez, Org. React. 26, 1 (1978).

The sulfonyl chlorides, IIa, can be isolated by extracting the inorganicby-products with water followed by drying the organic layer over adrying agent such as magnesium sulfate, filtering the dried solution andevaporation of the solvent.

Lithium salts of Formula IIb can be prepared by contacting sulfurdioxide with the lithiated intermediate IIc using procedures describedin the above references on the lithiated intermediates.

The formation of orthoesters, acetals, cyclic acetals, thioacetals andtheir amino analogs where Q₁ or Q₂ are N-CH₃ is widely reported in theliterature, c.f.: Synthetic Organic Chemistry, R. B. Wagner and H. D.Zook, Ch. 8, John Wiley & Sons, New York, 1953; or Organic Synthesis, V.Migrdichian, Ch. 5, Reinhold, London, 1957.

The desired aldehyde and acetyl substituted thiophenes can be preparedby a variety of methods as described, for example, in "The Chemistry ofHeterocyclic Compounds", vol. 3, edited by H. D. Hartough, F. P.Hochgesang and F. F. Blicke, Interscience, N.Y., 1952. Pyrazolealdehydes and acetylpyrazoles can be prepared according to proceduresdescribed in "The Chemistry of Heterocyclic Compounds", Vol. 22, editedby R. H. Wiley, Interscience, N.Y., 1967. Aldehydes and acetylderivatives of furan can be prepared according to methods cited in"Advances in Heterocyclic Chemistry", Vol. 7, edited by A. R. Katritzkyand A. J. Boulton, and Vol. 30 edited by A. R. Katritzky, AcademicPress, N.Y., 1962 and 1982. Further references to the literature ofheterocyclic compounds can be found on pages 225-299 of Vol. 7 citedabove.

The heterocyclic amines of Formula IIIa can be prepared by methods knownin the literature, or simple modifications thereof, by those skilled inthe art. For instance, No. EP-A-84,224 (published July 27, 1983) and W.Braker et al., J. Am. Chem. Soc., 69, 3072 (1947) describes methods forpreparing aminopyrimidines and triazines substituted by acetal groupssuch as dialkoxymethyl or 1,3-dioxolan-2-yl, among other groups. Also,for example, South African patent application Nos. 82/5045 and 82/5671describe methods for preparing aminopyrimidines and triazinessubstituted by haloalkyl or haloalkylthio groups such as OCH₂ CH₂ F,OCH₂ CF₃, SCF₂ H, or OCF₂ H, among other groups. South African patentapplication No. 83/7434 (published Oct. 5, 1983) describes methods forthe synthesis of cyclopropylpyrimidines and triazines substituted bysuch groups as alkyl, haloalkyl, alkoxy, haloalkoxy, alkylamino,dialkylamino or alkoxyalkyl.

The 5,6-dihydrofuro[2.3-d]pyrimidin-2-amines, thecyclopenta[d]pyrimidin-2-amines (IIIa, A is A-2) and the6,7-dihydro-5H-pyrano[2.3-d]pyrimidin-2-amines (IIIa, A is A-3) can beprepared as described in No. EP-A-15,683. Thefuro[2.3-d]pyrimidin-2-amines (III, A is A-4) are described in No.EP-A-46,677.

Compounds of Formula IIIa, where A is A-5, are described in No.EP-A-73,562. Compounds of Formula IIIa, where A is A-6, are described inNo. EP-A-94,260. Compounds of Formula IIIa, where A is A-7, can beprepared by methods taught in No. EP-A-125,864.

In addition, general methods for preparing aminopyrimidines andtriazines have been reviewed in the following publications:

"The Chemistry of Heterocyclic Compounds," a series published byInterscience Publ., New York and London;

"Pyrimidines", Vol. 16 of the same series by D. J. Brown;

"s-Triazines and Derivatives," Vol. 13 of the same series by E. M.Smolin and L. Rapaport;

F. C. Schaefer, U.S. Pat. No. 3,154,547 and K. R. Huffman and F. C.Schaefer, J. Org. Chem., 28, 1812 (1963), which describes the synthesisof triazines.

Agriculturally suitable salts of compounds of Formula I are also usefulherbicides and can be prepared in a number of ways known in the art. Forexample, metal salts can be made by contacting compounds of Formula Iwith a solution of an alkali or alkaline earth metal salt having asufficiently basic anion (e.g., hydroxide, alkoxide or carbonate).Quaternary amine salts can be made by similar techniques.

Salts of compounds of Formula I can also be prepared by exchange of onecation for another. Cationic exchange can be effected by direct contactof an aqueous solution of a salt of a compound of Formula I (e.g.,alkali or quaternary amine salt) with a solution containing the cationto be exchanged. This method is most effective when the desired saltcontaining the exchanged cation is insoluble in water and can beseparated by filtration.

Exchange may also be effected by passing an aqueous solution of a saltof a compound of Formula I (e.g., an alkali metal or quaternary aminesalt) through a column packed with a cation exchange resin containingthe cation to be exchanged for that of the original salt and the desiredproduct is eluted from the column. This method is particularly usefulwhen the desired salts is water-soluble.

Acid addition salts, useful in this invention, can be obtained byreacting a compound of Formula I with a suitable acid, e.g.,p-toluenesulfonic acid, trichloroacetic acid or the like.

The preparation of the compounds of this invention is furtherillustrated by the following specific examples. Unless otherwiseindicated, temperatures are given in degrees centigrade.

EXAMPLE 1 3-(1,3-Dioxolan-2-yl)thiophene-2-sulfonyl chloride

To 23.4 g of 3-(1,3-dioxolan-2-yl)thiophene (S. Gronowitz, et al.,Arkiv. Kemi., 20, 407 (1963)) in 100 ml of anhydrous tetrahydrofuran wasadded 100 ml of 1.6 molar n-butyllithium in hexane, with ice bathcooling. After stirring at room temperature for 20 minutes the mixturewas cooled to -78° and sulfuryl chloride (16.2 g) was then addeddropwise. This addition caused the suspended solids to form a tarry masswhich broke up when the mixture was allowed to warm to room temperature.After stirring one and one half hours at room temperature the mixturewas cooled to -10° and 10 ml of ethyl acetate was added dropwise. Thereaction mixture was then poured into ice water and extracted with ethylether. The ether portions were combined, dried over magnesium sulfate,filtered and the ether removed in-vacuo to yield 19.6 g of an oil.Infrared absorption spectra of this product showed peaks at 1330 and1180 cm⁻¹, consistent for the desired sulfonyl chloride. Mass spectrumanalysis: calc. 254, found 253 (Mass-1H) and the presence of a chlorineatom.

EXAMPLE 2 3-(1,3-Dioxolan-2-yl)thiophene-2-sulfonamide

To 5 ml of liquified ammonia gas dissolved in 50 ml of tetrahydrofuranwas added dropwise with stirring and cooling 12.7 g of3-(1,3-dioxolan-2-yl)thiophene-2-sulfonyl chloride. After stirringovernight at ambient temperature, the tetrahydrofuran was removed invacuo, water was added to the residue and the mixture was extractedtwice with 75 ml of methylene chloride. After washing the combinedmethylene chloride extracts with water, drying over magnesium sulfate,filtering off the drying agent and evaporation of the methylenechloride, an oily solid residue was obtained. This was chromatographedthrough silica gel using 1:1 ethyl acetate-hexanes as eluant (Rf 0.35).Evaporation of the solvent mixture yielded 2.2 g of the desired product,as a waxy solid. Infrared absorption spectra showed peaks at 3360, 3260,1340 and 1140 cm⁻¹, consistent for a primary sulfonamide. Mass spectrumanalysis: calc. 235, found 234 (Mass-1H).

EXAMPLE 33-(1,3-Dioxolan-2-yl)-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]-2-thiophenesulfonamide

To 0.47 g of 3-(1,3-dioxolan-2-yl)thiophene-2-sulfonamide in 20 ml ofacetonitrile was added 0.52 g ofphenyl(4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamate and 0.3 ml of1,8-diazabicyclo[5.4.0]-undec-7-ene (DBU). After stirring at ambienttemperatures for two hours the solution was diluted to 50 ml with waterand the pH was adjusted to 3 by the addition of hydrochloric acid. Theresultant solution was extracted with methylene chloride and themethylene chloride phase was dried over magnesium sulfate, filtered andevaporated. Trituration of the residue with butyl chloride yielded 0.6 gof the product, m.p. 164°-166°. Infrared absorption spectra showed peaksat 1700, 1600 and 1550 cm⁻¹, consistent for the desired structure.

NMR (CDCl₃): δ 2.56 (s, CH₃); 4.04 (s, OCH₃); 6.43 ##STR27## 4.95 (t,(CH₂)₂); 7.25 (d, thiophene); 7.58 (d, thiophene).

EXAMPLE 4N-4,6-Dimethoxypyrimidin-2-yl)aminocarbonyl]-3-(1,3-dioxolan-2-yl)-2-thiophenesulfonamide

To 0.47 g of 3-(1,3-dioxolan-2-yl)thiophene-2-sulfonamide in 20 ml ofacetonitrile was added 0.5 g of phenyl(4,6-dimethoxypyrimidin-2-yl)carbamate and 0.3 ml of DBU. After stirringfor two hours at ambient temperature, 25 ml of water was added to themixture and the solution was acidified to pH 3 with 10% hydrochloricacid. The precipitated product was removed by filtration, washed withwater and air dried to yield 0.9 g of the subject compound, m.p.157-168. Infrared absorption peaks at 1700, 1600, 1570 cm⁻¹ wereconsistent for the desired structure.

NMR (CDCl₃): δ 3.95 (m, CH₂ O); 3.95 (s, CH₃ O); 5.77 (s, pyrimidine);6.44 (s, dioxolane); 7.25 (d, thiophene); 7.57 (d, thiophene).

By using the procedures described in the foregoing equations andexamples or modifications thereof, one skilled in the art can preparethe compounds shown in the following tables.

    ______________________________________                                        TABLE OF STRUCTURES                                                           ______________________________________                                         ##STR28##                                                                    GENERAL STRUCTURE I                                                            ##STR29##                                                                    GENERAL STRUCTURE Ia                                                           ##STR30##                                                                    GENERAL STRUCTURE Ib                                                           ##STR31##                                                                    GENERAL STRUCTURE Ic                                                           ##STR32##                                                                    GENERAL STRUCTURE Id                                                           ##STR33##                                                                    GENERAL STRUCTURE Ie                                                           ##STR34##                                                                    GENERAL STRUCTURE II                                                           ##STR35##                                                                    GENERAL STRUCTURE IIa                                                          ##STR36##                                                                    GENERAL STRUCTURE IIb                                                          ##STR37##                                                                    GENERAL STRUCTURE IIc                                                          ##STR38##                                                                    GENERAL STRUCTURE III                                                          ##STR39##                                                                    GENERAL STRUCTURE IIIa                                                         ##STR40##                                                                    GENERAL STRUCTURE IIIb                                                         ##STR41##                                                                    GENERAL STRUCTURE IV                                                           ##STR42##                                                                    GENERAL STRUCTURE IVa                                                          ##STR43##                                                                    GENERAL STRUCTURE IVb                                                          ##STR44##                                                                    GENERAL STRUCTURE V                                                            ##STR45##                                                                    GENERAL STRUCTURE Va                                                           ##STR46##                                                                    GENERAL STRUCTURE Vb                                                           ##STR47##                                                                    GENERAL FORMULA Vc                                                             ##STR48##                                                                    GENERAL STRUCTURE VI                                                           ##STR49##                                                                    GENERAL STRUCTURE VIa                                                          ##STR50##                                                                    GENERAL STRUCTURE VIb                                                          ##STR51##                                                                    GENERAL STRUCTURE VII                                                          ##STR52##                                                                    GENERAL STRUCTURE VIIa                                                        ______________________________________                                    

                                      TABLE I                                     __________________________________________________________________________    GENERAL STRUCTURE I                                                           R.sub.1     R.sub.2                                                                           R  W X      Y        Z  m.p. °C.                       __________________________________________________________________________    1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             CH.sub.3 N                                        1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        1,3-dioxolan-2-yl                                                                         H   H  O Cl     OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.2 CH.sub.3                                                                   NHCH.sub.3                                                                             N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCF.sub.2 H                                                                          CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CF.sub.2 H                                                                           OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CF.sub.2 H                                                                           OCH.sub.3                                                                              N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.2 CH.sub.2 F                                                                 CH.sub.3 N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.2 CHF.sub.2                                                                  CH.sub.3 N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.2 CF.sub.3                                                                   CH.sub.3 N                                        1,3-dioxolan-2-yl                                                                         H   H  O CF.sub.3                                                                             CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CF.sub.3                                                                             OCH.sub.3                                                                              N                                        1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             NHCH.sub.3                                                                             N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            N(CH.sub.3).sub.2                                                                      N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            N(CH.sub.3)OCH.sub.3                                                                   N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                     N                                        1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             CH.sub.2 OCH.sub.2                                                                     CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             SCH.sub.3                                                                              N                                        1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             OCH.sub.2 CH═CH.sub.2                                                              N                                        1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             OCH.sub.2 C.tbd.CH                                                                     N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            CH.sub.2 OCH.sub.2 CH.sub.3                                                            N                                        1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             CH.sub.2 OCH.sub.2 CH.sub.3                                                            N                                        1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             OCH.sub.2 CH.sub.2 OCH.sub.3                                                           CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             OCH.sub.2 CH.sub.2 OCH.sub.3                                                           N                                        1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             CH.sub.2 SCH.sub.3                                                                     N                                        1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             CH.sub.2 SCH.sub.3                                                                     CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             CH(OCH.sub.3).sub.2                                                                    CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             i-C.sub.3 H.sub.7                                                                      CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             CH(OCH.sub.3).sub.2                                                                    N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            1,3-dioxolan-                                                                          CH                                                                   2-yl                                              1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            1,3-dioxolan-2                                                                         N                                                                    2-yl                                              1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            4-methyl-1,3-                                                                          N                                                                    dioxolan-2-yl                                     1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            4-methyl-1,3-                                                                          CH                                                                   dioxolan-2-yl                                     1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            4-ethyl-1,3-                                                                           CH                                                                   dioxolan-2-yl                                     1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            1,3-dioxan-2-yl                                                                        N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            1,3-dioxan-2-yl                                                                        CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            cyclopropyl                                                                            CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCF.sub.2 H                                                                          OCF.sub.2 H                                                                            CH                                       1,3-dioxolan-2-yl                                                                         H   H  O Br     OCF.sub.2 H                                                                            CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            cyclopropyl                                                                            N                                        1,3-dioxolan-2-yl                                                                         H   H  O F      CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         H   H  O F      OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O Br     OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O Br     CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         H   H  O I      OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            cyclopropyl                                                                            CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.2 CH.sub.3                                                                   cyclopropyl                                                                            N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.2 CH.sub.2 F                                                                 cyclopropyl                                                                            N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            cyclopropyl                                                                            N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            CH(SCH.sub.3).sub.2                                                                    N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            CH(SCH.sub.3).sub.2                                                                    CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            1,3-dithiolan-                                                                         CH                                                                   2-yl                                              1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            1,3-dithiolan-                                                                         N                                                                    2-yl                                              1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            1,3-oxathiolan-                                                                        N                                                                    2-yl                                              1,3-dioxolan-2-yl                                                                         H   CH.sub.3                                                                         O OCH.sub.3                                                                            CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         H   CH.sub.3                                                                         O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   CH.sub.3                                                                         O CH.sub.3                                                                             CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         H   CH.sub.3                                                                         O CH.sub.3                                                                             CH.sub.3 N                                        1,3-dioxolan-2-yl                                                                         H   CH.sub.3                                                                         O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        1,3-dioxolan-2-yl                                                                         H   CH.sub.3                                                                         O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        1,3-dioxolan-2-yl                                                                         H   CH.sub.3                                                                         O Cl     OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  S CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  S CH.sub.3                                                                             CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         H   H  S OCH.sub.3                                                                            CH.sub.3 N                                        1,3-dioxolan-2-yl                                                                         H   H  S OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        1,3-dithiolan-2-yl                                                                        H   H  O OCH.sub.3                                                                            CH.sub.3 CH                                       1,3-dithiolan-2-yl                                                                        H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       1,3-dithiolan-2-yl                                                                        H   H  O Cl     OCH.sub.3                                                                              CH                                       1,3-dithiolan-2-yl                                                                        H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       1,3-dithiolan-2-yl                                                                        H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        1,3-ditholan-2-yl                                                                         H   H  O OCH.sub.3                                                                            CH.sub.3 N                                        1,3-dithiolan-2-yl                                                                        H   H  O OCH.sub.2 CF.sub.3                                                                   NHCH.sub.3                                                                             N                                        1,3-dithiolan-2-yl                                                                        H   H  O OCH.sub.2 CH.sub.2 F                                                                 NHCH.sub.3                                                                             N                                        --CH(OCH.sub.3).sub.2                                                                     H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       --CH(OCH.sub.3).sub.2                                                                     H   H  O CH.sub.3                                                                             CH.sub.3 N                                        --CH(OCH.sub.3).sub.2                                                                     H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N  147-165                               --CH(OCH.sub.3).sub.2                                                                     H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       --CH(OCH.sub.3).sub.2                                                                     H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH 156-158                               --CH(OCH.sub.3).sub.2                                                                     H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N  135-139                               --CH(OCH.sub.3).sub.2                                                                     H   H  O Cl     OCH.sub.3                                                                              CH 151-154                               --C(CH.sub.3)(OCH.sub.3).sub.2                                                            H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       --C(CH.sub.3)(OCH.sub.3).sub.2                                                            H   H  O CH.sub.3                                                                             CH.sub.3 N                                        --C(CH.sub.3)(OCH.sub.3).sub.2                                                            H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N  120-126                               -- C(CH.sub.3)(OCH.sub.3).sub.2                                                           H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH 141-144                               --C(CH.sub.3)(OCH.sub.3).sub.2                                                            H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH 148-152                               --C(CH.sub.3)(OCH.sub.3).sub.2                                                            H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        --C(CH.sub.3)(OCH.sub.3).sub.2                                                            H   H  O Cl     OCH.sub.3                                                                              CH                                       --CH(OC.sub.2 H.sub.5).sub.2                                                              H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       --CH(OC.sub.2 H.sub.5).sub.2                                                              H   H  O CH.sub.3                                                                             CH.sub.3 N                                        --CH(OC.sub.2 H.sub.5).sub.2                                                              H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        --CH(OC.sub.2 H.sub.5).sub.2                                                              H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       --CH(OC.sub.2 H.sub.5).sub.2                                                              H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       --CH(OC.sub.2 H.sub.5).sub.2                                                              H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        --CH(SCH.sub.3).sub.2                                                                     H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       --CH(SCH.sub.3).sub.2                                                                     H   H  O CH.sub.3                                                                             CH.sub.3 N                                        --CH(SCH.sub.3).sub.2                                                                     H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        --CH(SCH.sub.3).sub.2                                                                     H   H  O OCH.sub. 3                                                                           OCH.sub.3                                                                              CH                                       --CH(SCH.sub.3).sub.2                                                                     H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        2-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             CH.sub.3 N                                        dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H   H  O Cl     OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H   H  O Br     OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H   H  O OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                             N                                        dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             CH.sub.2 N                                        dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H   H  O Cl     OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H   H  O Br     OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 1,3-oxathiolan-2-yl                                                                       H   H  O OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                             N                                        1,3-oxathiolan-2-yl                                                                       H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       1,3-oxathiolan-2-yl                                                                       H   H  O CH.sub.3                                                                             CH.sub.3 N                                        1,3-oxathiolan-2-yl                                                                       H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        1,3-oxathiolan-2-yl                                                                       H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       1,3-oxathiolan-2-yl                                                                       H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       1,3-oxathiolan-2-yl                                                                       H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        1,3-oxathiolan-2-yl                                                                       H   H  O Cl     OCH.sub.3                                                                              CH                                       1,3-oxathiolan-2-yl                                                                       H   H  O OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                             N                                        2-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       dithiolan-2-yl                                                                2-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             CH.sub.3 N                                        dithiolan-2-yl                                                                2-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        dithiolan-2-yl                                                                2-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       dithiolan-2-yl                                                                2-methyl-1,3-                                                                             H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       dithiolan-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        pyrimidin-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       pyrimidin-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H   H  O CH.sub.3                                                                             CH.sub.3 N                                        pyrimidin-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        pyrimidin-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       pyrimidin-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       pyrimidin-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        pyrimidin-2-yl                                                                4,5-dimethyl-1,3-                                                                         H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       dioxolan-2-yl                                                                 4,5-dimethyl-1,3-                                                                         H   H  O CH.sub.3                                                                             CH.sub.3 N                                        dioxolan-2-yl                                                                 4,5-dimethyl-1,3-                                                                         H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        dioxolan-2-yl                                                                 4,5-dimethyl-1,3-                                                                         H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 4,5-dimethyl-1,3-                                                                         H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 4-ethyl-1,3-                                                                              H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       dioxolan-2-yl                                                                 4-ethyl-1,3-                                                                              H   H  O CH.sub.3                                                                             CH.sub.3 N                                        dioxolan-2-yl                                                                 4-ethyl-1,3-                                                                              H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        dioxolan-2-yl                                                                 4-ethyl-1,3-                                                                              H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 4-ethyl-1,3-                                                                              H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 1,3-dimethyl-2-                                                                           H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        imidazolinyl                                                                  1,3-dimethyl-2-                                                                           H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       imidazolinyl                                                                  1,3-dimethyl-2-                                                                           H   H  O CH.sub.3                                                                             CH.sub.3 N                                        imidazolinyl                                                                  1,3-dimethyl-2-                                                                           H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        imidazolinyl                                                                  1,3-dimethyl-2-                                                                           H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       imidazolinyl                                                                  1,3-dimethyl-2-                                                                           H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       imidazolinyl                                                                  1,3-dioxolan-2-yl                                                                         5-CH.sub.3                                                                        H  O CH.sub.3                                                                             CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         5-CH.sub.3                                                                        H  O OCH.sub.3                                                                            CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         5-CH.sub.3                                                                        H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         4-CH.sub.3                                                                        H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        1,3-dioxolan-2-yl                                                                         4-CH.sub.3                                                                        H  O OCH.sub.3                                                                            CH.sub.3 N                                        1,3-dioxolan-2-yl                                                                         4-CH.sub.3                                                                        H  O CH.sub.3                                                                             CH.sub.3 N                                        --C(OCH.sub.3).sub.3                                                                      H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O Cl     OCH.sub.3                                                                              CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O Br     OCH.sub.3                                                                              CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O CH.sub.3                                                                             H        CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O OCH.sub.3                                                                            H        CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O OCH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.5                                                              CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O OCF.sub.2 H                                                                          OCH.sub.3                                                                              CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O OCH.sub.3                                                                            CH(OCH.sub.3).sub.2                                                                    CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O CH.sub.3                                                                             OC.sub.2 H.sub.5                                                                       CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O CH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                     CH                                       --C(OCH.sub.3).sub. 3                                                                     H   H  O OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                     CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O OCH.sub.3                                                                            C.sub.2 H.sub.5                                                                        CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O Cl     OC.sub.2 H.sub.5                                                                       CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O OCH.sub.2 CH.sub.3                                                                   NHCH.sub.3                                                                             N                                        --C(OCH.sub.3).sub.3                                                                      H   H  O OCF.sub.2 H                                                                          CH.sub.3 CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O CF.sub.2 H                                                                           OCH.sub.3                                                                              CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O CF.sub.2 H                                                                           OCH.sub.3                                                                              N                                        --C(OCH.sub.3).sub.3                                                                      H   H  O OCH.sub.3                                                                            cyclo-   N                                                                    propyl                                            --C(OCH.sub.3).sub.3                                                                      H   H  O OCF.sub.2 H                                                                          OCF.sub.2 H                                                                            CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        --C(OCH.sub.3).sub.3                                                                      H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        --C(OCH.sub.3).sub.3                                                                      H   H  O CH.sub.3                                                                             CH.sub.3 N                                        --C(OC.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                    H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       2-methoxy-1,3-                                                                            H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 --C(OC.sub.2 H.sub. 5).sub.3                                                              H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O Cl     OCH.sub.3                                                                              CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O Br     OCH.sub.3                                                                              CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O CH.sub.3                                                                             H        CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O OCH.sub.3                                                                            H        CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O OCH.sub.2                                                                            CH.sub.2 OC.sub.2 H.sub.5                                                              CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O OCF.sub.2 H                                                                          OCH.sub.3                                                                              CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O OCH.sub.3                                                                            CH(OCH.sub.3).sub.2                                                                    CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O CH.sub.3                                                                             OC.sub.2 H.sub.5                                                                       CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O CH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                     CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                     CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O OCH.sub.3                                                                            C.sub.2 H.sub.5                                                                        CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O Cl     OC.sub.2 H.sub.5                                                                       CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O OCH.sub.2 CH.sub.3                                                                   NHCH.sub.3                                                                             N                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O OCF.sub.2 H                                                                          CH.sub.3 CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O CF.sub.2 H                                                                           OCH.sub.3                                                                              CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O CF.sub.2 H                                                                           OCH.sub.3                                                                              N                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O OCH.sub.3                                                                            cyclo-   N                                                                    propyl                                            --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O OCF.sub.2 H                                                                          OCF.sub.2 H                                                                            CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O CH.sub.3                                                                             CH.sub.3 N                                        --C(OCH.sub.3)(OCH.sub.2 H.sub.5).sub.2                                                   H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       2-ethoxy-1,3-                                                                             H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H   H  O Cl     OCH.sub.3                                                                              CH                                       --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        --C(C.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                     H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       --C(C.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                     H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       --C(C.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                     H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       --C(C.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                     H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        --C(C.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                     H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        --C( -n-C.sub. 3 H.sub.7)(OCH.sub.3).sub.2                                                H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       2-ethyl-1,3-                                                                              H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 2-ethyl-1,3-                                                                              H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 2-ethyl-1,3-                                                                              H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        dioxolan-2-yl                                                                 2-propyl-1,3-                                                                             H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 2-propyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 2-propyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        dioxolan-2-yl                                                                 1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            C.tbd.CH CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            CF.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            SCF.sub.2 H                                                                            CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.2 F                                                                           OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            H        CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             OC.sub.2 H.sub.5                                                                       CH                                       C(OCH.sub.3).sub.3                                                                        H   H  O F      OCH.sub.3                                                                              CH                                       C(OCH.sub.3).sub.3                                                                        H   H  O I      OCH.sub.3                                                                              CH                                       C(OCH.sub.3).sub.3                                                                        H   H  O OCH.sub.3                                                                            C.tbd.CH CH                                       __________________________________________________________________________

                                      TABLE Ia                                    __________________________________________________________________________    GENERAL STRUCTURE Ia                                                          R.sub.1     R.sub.12                                                                         R  W X      Y        Z  m.p. °C.                        __________________________________________________________________________    1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             CH.sub.3 N                                         1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         1,3-dioxolan-2-yl                                                                         H  H  O Cl     OCH.sub.3                                                                              CH                                        1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.2 CH.sub.3                                                                   NHCH.sub.3                                                                             N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCF.sub.2 H                                                                          CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                         H  H  O CF.sub.2 H                                                                           OCH.sub.3                                                                              CH                                        1,3-dioxolan-2-yl                                                                         H  H  O CF.sub.2 H                                                                           OCH.sub.3                                                                              N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.2 CH.sub.2 F                                                                 CH.sub.3 N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.2 CHF.sub.2                                                                  CH.sub.3 N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.2 CF.sub.3                                                                   CH.sub.3 N                                         1,3-dioxolan-2-yl                                                                         H  H  O CF.sub.3                                                                             CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                         H  H  O CF.sub.3                                                                             OCH.sub.3                                                                              N                                         1,3-dioxolan-2-yl                                                                         H  H  O CH.sub. 3                                                                            NHCH.sub.3                                                                             N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            N(CH.sub.3).sub.2                                                                      N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            N(CH.sub.3)OCH.sub.3                                                                   N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                     N                                         1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                     CH                                        1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             SCH.sub.3                                                                              N                                         1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             OCH.sub.2 CH═CH.sub.2                                                              N                                         1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             OCH.sub.2 C.tbd.CH                                                                     N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            CH.sub.2 OCH.sub.2 CH.sub.3                                                            N                                         1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                                                              N                                         1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             OCH.sub.2 CH.sub.2 OCH.sub.3                                                           CH                                        1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             OCH.sub.2 CH.sub.2 OCH.sub.3                                                           N                                         1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             CH.sub.2 SCH.sub.3                                                                     N                                         1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             CH.sub.2 SCH.sub.3                                                                     CH                                        1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             CH(OCH.sub.3).sub.2                                                                    CH                                        1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             i-C.sub.3 H.sub.7                                                                      CH                                        1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             CH(OCH.sub.3).sub.2                                                                    N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            1,3-dioxolan-2-yl                                                                      CH                                        1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            1,3-dioxolan-2-yl                                                                      N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            4-methyl-1,3-                                                                          N                                                                    dioxolan-2-yl                                      1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            4-methyl-1,3-                                                                          CH                                                                   dioxolan-2-yl                                      1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            4-ethyl-1,3-                                                                           CH                                                                   dioxolan-2-yl                                      1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            1,3-dioxan-2-yl                                                                        N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            1,3-dioxan-2-yl                                                                        CH                                        1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            cyclopropyl                                                                            CH                                        1,3-dioxolan-2-yl                                                                         H  H  O OCF.sub.2 H                                                                          OCF.sub.2 H                                                                            CH                                        1,3-dioxolan-2-yl                                                                         H  H  O Br     OCF.sub.2 H                                                                            CH                                        1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            cyclopropyl                                                                            N                                         1,3-dioxolan-2-yl                                                                         H  H  O F      CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                         H  H  O F      OCH.sub.3                                                                              CH                                        1,3-dioxolan-2-yl                                                                         H  H  O Br     OCH.sub.3                                                                              CH                                        1,3-dioxolan-2-yl                                                                         H  H  O Br     CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                         H  H  O I      OCH.sub.3                                                                              CH                                        1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            cyclopropyl                                                                            CH                                        1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.2 CH.sub.3                                                                   cyclopropyl                                                                            N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.2 CH.sub.2 F                                                                 cyclopropyl                                                                            N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            cyclopropyl                                                                            N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            CH(SCH.sub.3).sub.2                                                                    N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            CH(SCH.sub.3).sub.2                                                                    CH                                        1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            1,3-dithiolan-2-yl                                                                     CH                                        1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            1,3-dithiolan-2-yl                                                                     N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            1,3-oxathiolan-2-yl                                                                    N                                         1,3-dioxolan-2-yl                                                                         H  CH.sub.3                                                                         O OCH.sub.3                                                                            CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                         H  CH.sub.3                                                                         O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        1,3-dioxolan-2-yl                                                                         H  CH.sub.3                                                                         O CH.sub.3                                                                             CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                         H  CH.sub.3                                                                         O CH.sub.3                                                                             CH.sub.3 N                                         1,3-dioxolan-2-yl                                                                         H  CH.sub.3                                                                         O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         1,3-dioxolan-2-yl                                                                         H  CH.sub.3                                                                         O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         1,3-dioxolan-2-yl                                                                         H  CH.sub.3                                                                         O Cl     OCH.sub.3                                                                              CH                                        1,3-dioxolan-2-yl                                                                         H  H  S CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        1,3-dioxolan-2-yl                                                                         H  H  S CH.sub.3                                                                             CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                         H  H  S OCH.sub.3                                                                            CH.sub.3 N                                         1,3-dioxolan-2-yl                                                                         H  H  S OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         1,3-dithiolan-2-yl                                                                        H  H  O OCH.sub.3                                                                            CH.sub.3 CH                                        1,3-dithiolan-2-yl                                                                        H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        1,3-dithiolan-2-yl                                                                        H  H  O Cl     OCH.sub.3                                                                              CH                                        1,3-dithiolan-2-yl                                                                        H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        1,3-dithiolan-2-yl                                                                        H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         1,3-dithiolan-2-yl                                                                        H  H  O OCH.sub.3                                                                            CH.sub.3 N                                         1,3-dithiolan-2-yl                                                                        H  H  O OCH.sub.2 CF.sub.3                                                                   NHCH.sub.3                                                                             N                                         1,3-dithiolan-2-yl                                                                        H  H  O OCH.sub.2 CH.sub.2 F                                                                 NHCH.sub.3                                                                             N                                         --CH(OCH.sub.3).sub.2                                                                     H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        --CH(OCH.sub.3).sub.2                                                                     H  H  O CH.sub.3                                                                             CH.sub.3 N                                         --CH(OCH.sub.3).sub.2                                                                     H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         --CH(OCH.sub.3).sub.2                                                                     H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        --CH(OCH.sub.3).sub.2                                                                     H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        --CH(OCH.sub.3).sub.2                                                                     H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         --CH(OCH.sub.3).sub.2                                                                     H  H  O Cl     OCH.sub.3                                                                              CH                                        --C(CH.sub.3)(OCH.sub.3).sub.2                                                            H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        --C(CH.sub.3)(OCH.sub.3).sub.2                                                            H  H  O CH.sub.3                                                                             CH.sub.3 N                                         --C(CH.sub.3)(OCH.sub.3).sub.2                                                            H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         --C(CH.sub.3)(OCH.sub.3).sub.2                                                            H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        --C(CH.sub.3)(OCH.sub.3).sub.2                                                            H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        --C(CH.sub.3)(OCH.sub.3).sub.2                                                            H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         --C(CH.sub.3)(OCH.sub.3).sub.2                                                            H  H  O Cl     OCH.sub. 3                                                                             CH                                        --CH(OC.sub.2 H.sub.5).sub.2                                                              H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        --CH(OC.sub.2 H.sub.5).sub.2                                                              H  H  O CH.sub.3                                                                             CH.sub.3 N                                         --CH(OC.sub.2 H.sub.5).sub.2                                                              H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         --CH(OC.sub.2 H.sub.5).sub.2                                                              H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        --CH(OC.sub.2 H.sub.5).sub.2                                                              H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        --CH(OC.sub.2 H.sub.5).sub.2                                                              H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         --CH(SCH.sub.3).sub.2                                                                     H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        --CH(SCH.sub.3).sub.2                                                                     H  H  O CH.sub.3                                                                             CH.sub.3 N                                         --CH(SCH.sub.3).sub.2                                                                     H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         --CH(SCH.sub.3).sub.2                                                                     H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        --CH(SCH.sub.3).sub.2                                                                     H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         2-methyl-1,3-                                                                             H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H  H  O CH.sub.3                                                                             CH.sub.3 N                                         dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         dioxolan-2-y1                                                                 2-methyl-1,3-                                                                             H  H  O Cl     OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H  H  O Br     OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H  H  O OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                             N                                         dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H  H  O CH.sub.3                                                                             CH.sub.3 N                                         dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H  H  O Cl     OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H  H  O Br     OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 1,3-oxathiolan-2-yl                                                                       H  H  O OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                             N                                         1,3-oxathiolan-2-yl                                                                       H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        1,3-oxathiolan-2-yl                                                                       H  H  O CH.sub.3                                                                             CH.sub.3 N                                         1,3-oxathiolan-2-yl                                                                       H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         1,3-oxathiolan-2-yl                                                                       H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        1,3-oxathiolan-2-yl                                                                       H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        1,3-oxathiolan-2-yl                                                                       H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         1,3-oxathiolan-2-yl                                                                       H  H  O Cl     OCH.sub.3                                                                              CH                                        1,3-oxathiolan-2-yl                                                                       H  H  O OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                             N                                         2-methyl-1,3-                                                                             H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        dithiolan-2-yl                                                                2-methyl-1,3-                                                                             H  H  O CH.sub.3                                                                             CH.sub.3 N                                         dithiolan-2-yl                                                                2-methyl-1,3-                                                                             H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         dithiolan-2-yl                                                                2-methyl-1,3-                                                                             H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        dithiolan-2-yl                                                                2-methyl-1,3-                                                                             H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        dithiolan-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         pyrimidin-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        pyrimidin-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H  H  O CH.sub.3                                                                             CH.sub.3 N                                         pyrimidin-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         pyrimidin-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        pyrimidin-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        pyrimidin-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         pyrimidin-2-yl                                                                4,5-dimethyl-1,3-                                                                         H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        dioxolan-2-yl                                                                 4,5-dimethyl-1,3-                                                                         H  H  O CH.sub.3                                                                             CH.sub.3 N                                         dioxolan-2-yl                                                                 4,5-dimethyl-1,3-                                                                         H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         dioxolan-2-yl                                                                 4,5-dimethyl-1,3-                                                                         H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 4,5-dimethyl-1,3-                                                                         H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 4-ethyl-1,3-                                                                              H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        dioxolan-2-yl                                                                 4-ethyl-1,3-                                                                              H  H  O CH.sub.3                                                                             CH.sub.3 N                                         dioxolan-2-yl                                                                 4-ethyl-1,3-                                                                              H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         dioxolan-2-yl                                                                 4-ethyl-1,3-                                                                              H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 4-ethyl-1,3-                                                                              H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 1,3-dimethyl-2-                                                                           H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         imidazolinyl                                                                  1,3-dimethyl-2-                                                                           H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        imidazolinyl                                                                  1,3-dimethyl-2-                                                                           H  H  O CH.sub.3                                                                             CH.sub.3 N                                         imidazolinyl                                                                  1,3-dimethyl-2-                                                                           H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         imidazolinyl                                                                  1,3-dimethyl-2-                                                                           H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        imidazolinyl                                                                  1,3-dimethyl-2-                                                                           H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        imidazolinyl                                                                  1,3-dioxolan-2-yl                                                                         CH.sub.3                                                                         H  O CH.sub.3                                                                             CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                         CH.sub.3                                                                         H  O OCH.sub.3                                                                            CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                         CH.sub.3                                                                         H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        1,3-dioxolan-2-yl                                                                         CH.sub.3                                                                         H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         1,3-dioxolan-2-yl                                                                         CH.sub.3                                                                         H  O OCH.sub.3                                                                            CH.sub.3 N                                         1,3-dioxolan-2-yl                                                                         CH.sub.3                                                                         H  O CH.sub.3                                                                             CH.sub.3 N                                         --C(OCH.sub.3).sub.3                                                                      H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        --C(OCH.sub. 3).sub.3                                                                     H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O Cl     OCH.sub.3                                                                              CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O Br     OCH.sub.3                                                                              CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O CH.sub.3                                                                             H        CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O OCH.sub.3                                                                            H        CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O OCH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.5                                                              CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O OCF.sub.2 H                                                                          OCH.sub.3                                                                              CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O OCH.sub.3                                                                            CH(OCH.sub.3).sub.2                                                                    CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O CH.sub.3                                                                             OC.sub.2 H.sub.5                                                                       CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O CH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                     CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                     CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O OCH.sub.3                                                                            C.sub.2 H.sub.5                                                                        CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O Cl     OC.sub.2 H.sub.5                                                                       CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O OCH.sub.2 CH.sub.3                                                                   NHCH.sub.3                                                                             N                                         --C(OCH.sub.3).sub.3                                                                      H  H  O OCF.sub.2 H                                                                          CH.sub.3 CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O CF.sub.2 H                                                                           OCH.sub.3                                                                              CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O CF.sub.2 H                                                                           OCH.sub.3                                                                              N                                         --C(OCH.sub.3).sub.3                                                                      H  H  O OCH.sub.3                                                                            cyclo-   N                                                                    propyl                                             --C(OCH.sub.3).sub.3                                                                      H  H  O OCF.sub.2 H                                                                          OCF.sub.2 H                                                                            CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         --C(OCH.sub.3).sub.3                                                                      H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         --C(OCH.sub.3).sub.3                                                                      H  H  O CH.sub.3                                                                             CH.sub.3 N                                         --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O Cl     OCH.sub.3                                                                              CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O Br     OCH.sub.3                                                                              CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O CH.sub.3                                                                             H        CH                                        --C(OC.sub.2 H.sub.5 ).sub.3                                                              H  H  O OCH.sub.3                                                                            H        CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O OCH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.5                                                              CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O OCF.sub.2 H                                                                          OCH.sub.3                                                                              CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O OCH.sub.3                                                                            CH(OCH.sub.3).sub.2                                                                    CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O CH.sub.3                                                                             OC.sub.2 H.sub.5                                                                       CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O CH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                     CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                     CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O OCH.sub.3                                                                            C.sub.2 H.sub.5                                                                        CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O Cl     OC.sub.2 H.sub.5                                                                       CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O OCH.sub.2 CH.sub.3                                                                   NHCH.sub.3                                                                             N                                         --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O OCF.sub.2 H                                                                          CH.sub.3 CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O CF.sub.2 H                                                                           OCH.sub.3                                                                              CH                                        --C(OC.sub. 2 H.sub.5).sub.3                                                              H  H  O CF.sub.2 H                                                                           OCH.sub.3                                                                              N                                         --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O OCH.sub.3                                                                            cyclo-   N                                                                    propyl                                             --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O OCF.sub.2 H                                                                          OCF.sub.2 H                                                                            CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O CH.sub.3                                                                             CH.sub.3 N                                         --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H  H  O Cl     OCH.sub.3                                                                              CH                                        --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         --C(C.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                     H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        --C(C.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                     H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        --C(C.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                     H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        --C(C.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                     H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         --C(C.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                     H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         --C( -n-C.sub.3 H.sub.7)(OCH.sub.3).sub.2                                                 H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        2-ethyl-1,3-                                                                              H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 2-ethyl-1,3-                                                                              H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 2-ethyl-1,3-                                                                              H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         dioxolan-2-yl                                                                 2-propyl-1,3-                                                                             H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 2-propyl-1,3-                                                                             H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 2-propyl-1,3-                                                                             H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         dioxolan-2-yl                                                                 1,3-dioxolan-2-yl                                                                         C.sub.2 H.sub.5                                                                  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        1,3-dioxolan-2-yl                                                                         Cl H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        __________________________________________________________________________

                                      TABLE Ib                                    __________________________________________________________________________    GENERAL STRUCTURE Ib                                                          R.sub.1     R.sub.12                                                                         R  W X      Y        Z  m.p. °C.                        __________________________________________________________________________    1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             CH.sub.3 N                                         1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         1,3-dioxolan-2-yl                                                                         H  H  O Cl     OCH.sub.3                                                                              CH                                        1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.2 CH.sub.3                                                                   NHCH.sub.3                                                                             N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCF.sub.2 H                                                                          CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                         H  H  O CF.sub.2 H                                                                           OCH.sub.3                                                                              CH                                        1,3-dioxolan-2-yl                                                                         H  H  O CF.sub.2 H                                                                           OCH.sub.3                                                                              N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.2 CH.sub.2 F                                                                 CH.sub.3 N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.2 CHF.sub.2                                                                  CH.sub.3 N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.2 CF.sub.3                                                                   CH.sub.3 N                                         1,3-dioxolan-2-yl                                                                         H  H  O CF.sub.3                                                                             CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                         H  H  O CF.sub.3                                                                             OCH.sub.3                                                                              N                                         1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             NHCH.sub.3                                                                             N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            N(CH.sub.3).sub.2                                                                      N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            N(CH.sub.3)OCH.sub.3                                                                   N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                     N                                         1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                     CH                                        1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             SCH.sub.3                                                                              N                                         1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             OCH.sub.2 CH═CH.sub.2                                                              N                                         1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             OCH.sub.2 C.tbd.CH                                                                     N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            CH.sub.2 OCH.sub.2 CH.sub.3                                                            N                                         1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                                                              N                                         1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             OCH.sub.2 CH.sub.2 OCH.sub.3                                                           CH                                        1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             OCH.sub.2 CH.sub.2 OCH.sub.3                                                           N                                         1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             CH.sub.2 SCH.sub.3                                                                     N                                         1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             CH.sub.2 SCH.sub.3                                                                     CH                                        1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             CH(OCH.sub.3).sub.2                                                                    CH                                        1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             i-C.sub.3 H.sub.7                                                                      CH                                        1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             CH(OCH.sub.3)hd 2                                                                      N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            1,3-dioxolan-2-yl                                                                      CH                                        1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub. 3                                                                           1,3-dioxolan-2-yl                                                                      N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            4-methyl-1,3-                                                                          N                                                                    dioxolan-2-yl                                      1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            4-methyl-1,3-                                                                          CH                                                                   dioxolan-2-yl                                      1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            4-ethyl-1,3-                                                                           CH                                                                   dioxolan-2-yl                                      1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            1,3-dioxol-2-yl                                                                        N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            1,3-dioxol-2-yl                                                                        CH                                        1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            cyclopropyl                                                                            CH                                        1,3-dioxolan-2-yl                                                                         H  H  O OCF.sub.2 H                                                                          OCF.sub.2 H                                                                            CH                                        1,3-dioxolan-2-yl                                                                         H  H  O Br     OCF.sub.2 H                                                                            CH                                        1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            cyclopropyl                                                                            N                                         1,3-dioxolan-2-yl                                                                         H  H  O F      CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                         H  H  O F      OCH.sub.3                                                                              CH                                        1,3-dioxolan-2-yl                                                                         H  H  O Br     OCH.sub.3                                                                              CH                                        1,3-dioxolan-2-yl                                                                         H  H  O Br     CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                         H  H  O I      OCH.sub.3                                                                              CH                                        1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            cyclopropyl                                                                            CH                                        1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.2 CH.sub.3                                                                   cyclopropyl                                                                            N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.2 CH.sub.2 F                                                                 cyclopropyl                                                                            N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            cyclopropyl                                                                            N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            CH(SCH.sub.3).sub.2                                                                    N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            CH(SCH.sub.3 ).sub.2                                                                   CH                                        1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            1,3-dithiolan-2-yl                                                                     CH                                        1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            1,3-dithiolan-2-yl                                                                     N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            1,3-oxathiolan-2-yl                                                                    N                                         1,3-dioxolan-2-yl                                                                         H  CH.sub.3                                                                         O OCH.sub.3                                                                            CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                         H  CH.sub.3                                                                         O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        1,3-dioxolan-2-yl                                                                         H  CH.sub.3                                                                         O CH.sub.3                                                                             CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                         H  CH.sub.3                                                                         O CH.sub.3                                                                             CH.sub.3 N                                         1,3-dioxolan-2-yl                                                                         H  CH.sub.3                                                                         O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         1,3-dioxolan-2-yl                                                                         H  CH.sub.3                                                                         O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         1,3-dioxolan-2-yl                                                                         H  CH.sub.3                                                                         O Cl     OCH.sub.3                                                                              CH                                        1,3-dioxolan-2-yl                                                                         H  H  S CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        1,3-dioxolan-2-yl                                                                         H  H  S CH.sub.3                                                                             CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                         H  H  S OCH.sub.3                                                                            CH.sub.3 N                                         1,3-dioxolan-2-yl                                                                         H  H  S OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         1,3-dithiolan-2-yl                                                                        H  H  O OCH.sub.3                                                                            CH.sub.3 CH                                        1,3-dithiolan-2-yl                                                                        H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        1,3-dithiolan-2-yl                                                                        H  H  O Cl     OCH.sub.3                                                                              CH                                        1,3-dithiolan-2-yl                                                                        H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        1,3-dithiolan-2-yl                                                                        H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         1,3-dithiolan-2-yl                                                                        H  H  O OCH.sub.3                                                                            CH.sub.3 N                                         1,3-dithiolan-2-yl                                                                        H  H  O OCH.sub.2 CF.sub.3                                                                   NHCH.sub.3                                                                             N                                         1,3-dithiolan-2-yl                                                                        H  H  O OCH.sub.2 CH.sub.2 F                                                                 NHCH.sub.3                                                                             N                                         --CH(OCH.sub.3).sub.2                                                                     H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        --CH(OCH.sub.3).sub.2                                                                     H  H  O CH.sub.3                                                                             CH.sub.3 N                                         --CH(OCH.sub.3).sub.2                                                                     H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         --CH(OCH.sub.3).sub.2                                                                     H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        --CH(OCH.sub.3).sub.2                                                                     H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        --CH(OCH.sub.3).sub.2                                                                     H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         --CH(OCH.sub.3).sub.2                                                                     H  H  O Cl     OCH.sub.3                                                                              CH                                        --C(CH.sub.3)(OCH.sub.3).sub.2                                                            H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        --C(CH.sub.3)(OCH.sub.3).sub.2                                                            H  H  O CH.sub.3                                                                             CH.sub.3 N                                         --C(CH.sub.3)(OCH.sub.3).sub.2                                                            H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         --C(CH.sub.3)(OCH.sub.3).sub.2                                                            H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        --C(CH.sub.3)(OCH.sub.3).sub.2                                                            H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        --C(CH.sub.3)(OCH.sub.3).sub.2                                                            H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         --C(CH.sub.3)(OCH.sub.3).sub.2                                                            H  H  O Cl     OCH.sub.3                                                                              CH                                        --CH(OC.sub.2 H.sub.5).sub.2                                                              H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        --CH(OC.sub.2 H.sub.5).sub.2                                                              H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        --CH(OC.sub.2 H.sub.5).sub.2                                                              H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         --CH(OC.sub.2 H.sub.5).sub.2                                                              H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        --CH(OC.sub.2 H.sub.5).sub.2                                                              H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        --CH(OC.sub.2 H.sub.5).sub.2                                                              H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         --CH(SCH.sub.3).sub.2                                                                     H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        --CH(SCH.sub.3).sub.2                                                                     H  H  O CH.sub.3                                                                             CH.sub.3 N                                         --CH(SCH.sub.3).sub.2                                                                     H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         --CH(SCH.sub.3).sub.2                                                                     H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        --CH(SCH.sub.3).sub.2                                                                     H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         2-methyl-1,3-                                                                             H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H  H  O CH.sub.3                                                                             CH.sub.3 N                                         dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H  H  O Cl     OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H  H  O Br     OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H  H  O OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                             N                                         dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H  H  O CH.sub.3                                                                             CH.sub.3 N                                         dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H  H  O Cl     OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H  H  O Br     OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 1,3-oxathiolan-2-yl                                                                       H  H  O OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                             N                                         1,3-oxathiolan-2-yl                                                                       H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        1,3-oxathiolan-2-yl                                                                       H  H  O CH.sub.3                                                                             CH.sub.3 N                                         1,3-oxathiolan-2-yl                                                                       H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         1,3-oxathiolan-2-yl                                                                       H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        1,3-oxathiolan-2-yl                                                                       H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        1,3-oxathiolan-2-yl                                                                       H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         1,3-oxathiolan-2-yl                                                                       H  H  O Cl     OCH.sub.3                                                                              CH                                        1,3-oxathiolan-2-yl                                                                       H  H  O OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                             N                                         2-methyl-1,3-                                                                             H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        dithiolan-2-yl                                                                2-methy11-1,3-                                                                            H  H  O CH.sub.3                                                                             CH.sub.3 N                                         dithiolan-2-yl                                                                2-methyl-1,3-                                                                             H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         dithiolan-2-yl                                                                2-methyl-1,3-                                                                             H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        dithiolan-2-yl                                                                2-methyl-1,3-                                                                             H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        dithiolan-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         pyrimidin-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        pyrimidin-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H  H  O CH.sub.3                                                                             CH.sub.3 N                                         pyrimidin-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         pyrimidin-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        pyrimidin-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        pyrimidin-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         pyrimidin-2-yl                                                                4,5-dimethyl-1,3-                                                                         H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        dioxolan-2-yl                                                                 4,5-dimethyl-1,3-                                                                         H  H  O CH.sub.3                                                                             CH.sub.3 N                                         dioxolan-2-yl                                                                 4,5-dimethyl-1,3-                                                                         H  H  O CH.sub. 3                                                                            OCH.sub.3                                                                              N                                         dioxolan-2-yl                                                                 4,5-dimethyl-1,3-                                                                         H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 4,5-dimethyl-1,3-                                                                         H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 4-ethyl-1,3-                                                                              H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        dioxolan-2-yl                                                                 4-ethyl-1,3-                                                                              H  H  O CH.sub.3                                                                             CH.sub.3 N                                         dioxolan-2-yl                                                                 4-ethyl-1,3-                                                                              H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         dioxolan-2-yl                                                                 4-ethyl-1,3-                                                                              H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 4-ethyl-1,3-                                                                              H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 1,3-dimethyl-2-                                                                           H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         imidazolinyl                                                                  1,3-dimethyl-2-                                                                           H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        imidazolinyl                                                                  1,3-dimethyl-2-                                                                           H  H  O CH.sub.3                                                                             CH.sub.3 N                                         imidazolinyl                                                                  1,3-dimethyl-2-                                                                           H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         imidazolinyl                                                                  1,3-dimethyl-2-                                                                           H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        imidazolinyl                                                                  1,3-dimethyl-2-                                                                           H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        imidazolinyl                                                                  1,3-dioxolan-2-yl                                                                         CH.sub.3                                                                         H  O CH.sub.3                                                                             CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                         CH.sub.3                                                                         H  O OCH.sub.3                                                                            CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                         CH.sub.3                                                                         H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        1,3-dioxolan-2-yl                                                                         CH.sub.3                                                                         H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         1,3-dioxolan-2-yl                                                                         CH.sub.3                                                                         H  O OCH.sub.3                                                                            CH.sub. 3                                                                              N                                         1,3-dioxolan-2-yl                                                                         CH.sub.3                                                                         H  O CH.sub.3                                                                             CH.sub.3 N                                         --C(OCH.sub.3).sub.3                                                                      H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O Cl     OCH.sub.3                                                                              CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O Br     OCH.sub.3                                                                              CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O CH.sub.3                                                                             H        CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O OCH.sub.3                                                                            H        CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O OCH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.5                                                              CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O OCF.sub.2 H                                                                          OCH.sub.3                                                                              CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O OCH.sub.3                                                                            CH(OCH.sub.3).sub.2                                                                    CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O CH.sub.3                                                                             OC.sub.2 H.sub.5                                                                       CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O CH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                     CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                     CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O OCH.sub. 3                                                                           C.sub.2 H.sub.5                                                                        CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O Cl     OC.sub.2 H.sub.5                                                                       CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O OCH.sub.2 CH.sub.3                                                                   NHCH.sub.3                                                                             N                                         --C(OCH.sub.3).sub.3                                                                      H  H  O OCF.sub.2 H                                                                          CH.sub.3 CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O CF.sub.2 H                                                                           OCH.sub.3                                                                              CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O CF.sub.2 H                                                                           OCH.sub.3                                                                              N                                         --C(OCH.sub.3).sub.3                                                                      H  H  O OCH.sub.3                                                                            cyclo-   N                                                                    propyl                                             --C(OCH.sub.3).sub.3                                                                      H  H  O OCF.sub.2 H                                                                          OCF.sub.2 H                                                                            CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         --C(OCH.sub.3).sub.3                                                                      H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         --C(OCH.sub.3).sub.3                                                                      H  H  O CH.sub.3                                                                             CH.sub.3 N                                         --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        --C(OC.sub.2 H.sub.5).sub. 3                                                              H  H  O Cl     OCH.sub.3                                                                              CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O Br     OCH.sub.3                                                                              CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O CH.sub.3                                                                             H        CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O OCH.sub.3                                                                            H        CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O OCH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.5                                                              CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O OCF.sub.2 H                                                                          OCH.sub.3                                                                              CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O OCH.sub.3                                                                            CH(OCH.sub.3).sub.2                                                                    CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O CH.sub.3                                                                             OC.sub.2 H.sub.5                                                                       CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O CH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                     CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                     CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O OCH.sub.3                                                                            C.sub.2 H.sub.5                                                                        CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O Cl     OC.sub.2 H.sub.5                                                                       CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O OCH.sub.2 CH.sub. 3                                                                  NHCH.sub.3                                                                             N                                         --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O OCF.sub.2 H                                                                          CH.sub.3 CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O CF.sub.2 H                                                                           OCH.sub.3                                                                              CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O CF.sub.2 H                                                                           OCH.sub.3                                                                              N                                         --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O OCH.sub.3                                                                            cyclo-   N                                                                    propyl                                             --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O OCF.sub.2 H                                                                          OCF.sub.2 H                                                                            CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O CH.sub.3                                                                             CH.sub.3 N                                         --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H  H  O Cl     OCH.sub.3                                                                              CH                                        --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         --C(C.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                     H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        --C(C.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                     H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        --C(C.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                     H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        --C(C.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                     H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         --C(C.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                     H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         --C( -n-C.sub.3 H.sub.7)(OCH.sub.3).sub.2                                                 H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        2-ethyl-1,3-                                                                              H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 2-ethyl-1,3-                                                                              H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 2-ethyl-1,3-                                                                              H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         dioxolan-2-yl                                                                 2-propyl-1,3-                                                                             H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 2-propyl-1,3-                                                                             H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 2-propyl-1,3-                                                                             H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         dioxolan-2-yl                                                                 __________________________________________________________________________

                                      TABLE Ic                                    __________________________________________________________________________    GENERAL STRUCTURE Ic                                                          R.sub.1     R.sub.12                                                                          R  W X      Y        Z  m.p. °C.                       __________________________________________________________________________    1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O Cl     OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCF.sub.2 H                                                                          OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.2 CH.sub.2 F                                                                 NHCH.sub.3                                                                             N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.2 CH.sub.2 F                                                                 OC.sub.2 H.sub.5                                                                       N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.2 CHF.sub.2                                                                  OCH.sub.3                                                                              N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.2 CF.sub.3                                                                   NHCH.sub.3                                                                             N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.2 CF.sub.3                                                                   N(CH.sub.3).sub.2                                                                      N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.2 CF.sub.3                                                                   OCH.sub.3                                                                              N                                        1,3-dioxolan-2-yl                                                                         H   H  O CF.sub.3                                                                             OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O I      OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O Br     OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O F      OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             OC.sub.2 H.sub.5                                                                       N                                        1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                     CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             CH.sub.2 SCH.sub.3                                                                     CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCF.sub.2 H                                                                          OCF.sub.2 H                                                                            CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            NHCH.sub.3                                                                             CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            N(OCH.sub.3)CH.sub.3                                                                   N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            C.sub.2 H.sub.5                                                                        N                                        1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             OCH.sub.2 CH.sub.2 OCH.sub.3                                                           CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            cyclopropyl                                                                            N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            SCF.sub.2 H                                                                            CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            CH(OCH.sub.3).sub.2                                                                    CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            1,3-dioxolan-2-yl                                                                      CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             OCH.sub.2 C.tbd.CH                                                                     N                                        1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             OCH.sub.2 CH═CH.sub.2                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.5                                                              N                                        1,3-dioxolan-2-yl                                                                         4-CH.sub.3                                                                        H  O OCH.sub.3                                                                            CH.sub.3 N                                        1,3-dioxolan-2-yl                                                                         4-C.sub.2 H.sub.5                                                                 H  O OCH.sub.3                                                                            CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         4-Cl                                                                              H  O OCH.sub.3                                                                            CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         H   CH.sub.3                                                                         O CH.sub.3                                                                             CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         H   H  S CH.sub.3                                                                             CH.sub.3 CH                                       1,3-dithiolan-2-yl                                                                        H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       1,3-dithiolan-2-yl                                                                        H   H  O OCH.sub.3                                                                            CH.sub.3 CH                                       1,3-dithiolan-2-yl                                                                        H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       1,3-dithiolan-2-yl                                                                        H   H  O Cl     OCH.sub.3                                                                              CH                                       1,3-dithiolan-2-yl                                                                        H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        1,3-dithiolan-2-yl                                                                        H   H  O OCH.sub.3                                                                            CH.sub.3 N                                        CH(OCH.sub.3).sub.2                                                                       H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       CH(OCH.sub.3).sub.2                                                                       H   H  O OCH.sub.3                                                                            CH.sub.3 CH                                       CH(OCH.sub.3).sub.2                                                                       H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       CH(OCH.sub.3).sub.2                                                                       H   H  O Cl     OCH.sub.3                                                                              CH                                       CH(OCH.sub.3).sub.2                                                                       H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        CH(OCH.sub.3).sub.2                                                                       H   H  O OCH.sub.3                                                                            CH.sub.3 N                                        CH(OC.sub.2 H.sub.5).sub.2                                                                H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       CH(OC.sub.2 H.sub.5).sub.2                                                                H   H  O OCH.sub.3                                                                            CH.sub.3 CH                                       CH(OC.sub.2 H.sub.5).sub.2                                                                H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       CH(OC.sub.2 H.sub.5).sub.2                                                                H   H  O Cl     OCH.sub.3                                                                              CH                                       CH(OC.sub.2 H.sub.5).sub. 2                                                               H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        CH(OC.sub.2 H.sub.5).sub.2                                                                H   H  O OCH.sub.3                                                                            CH.sub.3 N                                        CH(SCH.sub.3).sub.2                                                                       H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       CH(SCH.sub.3).sub.2                                                                       H   H  O OCH.sub.3                                                                            CH.sub.3 CH                                       CH(SCH.sub.3).sub.2                                                                       H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       CH(SCH.sub.3).sub.2                                                                       H   H  O Cl     OCH.sub.3                                                                              CH                                       CH(SCH.sub.3).sub.2                                                                       H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        CH(SCH.sub.3).sub.2                                                                       H   H  O OCH.sub.3                                                                            CH.sub.3 N                                        C(CH.sub.3)(OCH.sub.3).sub.2                                                              H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       C(CH.sub.3)(OCH.sub.3).sub.2                                                              H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        C(CH.sub.3)(SCH.sub.3).sub.2                                                              H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       C(CH.sub.3)(SCH.sub.3).sub.2                                                              H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        2-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        dioxolan-2-yl                                                                 1,3-oxathiolan-2-yl                                                                       H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       1,3-oxathiolan-2-yl                                                                       H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        2-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       dithiolan-2-yl                                                                2-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        dithiolan-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       pyrimidin-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        pyrimidin-2-yl                                                                4,5-dimethyl-1,3-                                                                         H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 4,5-dimethyl-1,3-                                                                         H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N -dioxolan-2-yl                         4-ethyl-1,3-                                                                              H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 4-ethyl-1,3-                                                                              H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        dioxolan-2-yl                                                                 1,3-dimethyl-2-                                                                           H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       imidazolidinyl                                                                1,3-dimethyl-2-                                                                           H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        imidazolidinyl                                                                --C(OCH.sub.3).sub.3                                                                      H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O Cl     OCH.sub.3                                                                              CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        --C(OCH.sub.3).sub.3                                                                      H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        --C(OC.sub.2 H.sub.5 ).sub.3                                                              H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O Cl     OCH.sub.3                                                                              CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H   H  O Cl     OCH.sub.3                                                                              CH                                       --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        __________________________________________________________________________

                                      TABLE Id                                    __________________________________________________________________________    GENERAL STRUCTURE Id                                                          R.sub.1     R.sub.12                                                                          R  W X      Y        Z  m.p. °C.                       __________________________________________________________________________    1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O Cl     OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCF.sub.2 H                                                                          OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.2 CH.sub.2 F                                                                 NHCH.sub.3                                                                             N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.2 CH.sub.2 F                                                                 OC.sub.2 H.sub.5                                                                       N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.2 CHF.sub.2                                                                  OCH.sub.3                                                                              N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.2 CF.sub.3                                                                   NHCH.sub.3                                                                             N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.2 CF.sub.3                                                                   N(CH.sub.3).sub.2                                                                      N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.2 CF.sub.3                                                                   OCH.sub.3                                                                              N                                        1,3-dioxolan-2-yl                                                                         H   H  O CF.sub.3                                                                             OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O I      OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O Br     OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O F      OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             OC.sub.2 H.sub.5                                                                       N                                        1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                     CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             CH.sub.2 SCH.sub.3                                                                     CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCF.sub.2 H                                                                          OCF.sub.2 H                                                                            CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            NHCH.sub.3                                                                             CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            N(OCH.sub.3)CH.sub.3                                                                   N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            C.sub.2 H.sub.5                                                                        N                                        1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             OCH.sub.2 CH.sub.2 OCH.sub.3                                                           CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            cyclopropyl                                                                            N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            SCF.sub.2 H                                                                            CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            CH(OCH.sub.3).sub.2                                                                    CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            1,3-dioxolan-2-yl                                                                      CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             OCH.sub.2 C.tbd.CH                                                                     N                                        1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             OCH.sub.2 CH═CH.sub.2                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.5                                                              N                                        1,3-dioxolan-2-yl                                                                         CH.sub.3                                                                          H  O OCH.sub.3                                                                            CH.sub.3 N                                        1,3-dioxolan-2-yl                                                                         C.sub.2 H.sub.5                                                                   H  O OCH.sub.3                                                                            CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         Cl  H  O OCH.sub.3                                                                            CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         H   CH.sub.3                                                                         O CH.sub.3                                                                             CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         H   H  S CH.sub.3                                                                             CH.sub.3 CH                                       1,3-dithiolan-2-yl                                                                        H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       1,3-dithiolan-2-yl                                                                        H   H  O OCH.sub.3                                                                            CH.sub.3 CH                                       1,3-dithiolan-2-yl                                                                        H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       1,3-dithiolan-2-yl                                                                        H   H  O Cl     OCH.sub.3                                                                              CH                                       1,3-dithiolan-2-yl                                                                        H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        1,3-dithiolan-2-yl                                                                        H   H  O OCH.sub.3                                                                            CH.sub.3 N                                        CH(OCH.sub.3).sub.2                                                                       H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       CH(OCH.sub.3).sub.2                                                                       H   H  O OCH.sub.3                                                                            CH.sub.3 CH                                       CH(OCH.sub.3).sub.2                                                                       H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       CH(OCH.sub.3).sub.2                                                                       H   H  O Cl     OCH.sub.3                                                                              CH                                       CH(OCH.sub.3).sub.2                                                                       H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        CH(OCH.sub.3).sub.2                                                                       H   H  O OCH.sub.3                                                                            CH.sub.3 N                                        CH(OC.sub.2 H.sub.5).sub.2                                                                H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       CH(OC.sub.2 H.sub.5).sub.2                                                                H   H  O OCH.sub.3                                                                            CH.sub.3 CH                                       CH(OC.sub.2 H.sub.5).sub.2                                                                H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       CH(OC.sub.2 H.sub.5).sub.2                                                                H   H  O Cl     OCH.sub.3                                                                              CH                                       CH(OC.sub.2 H.sub.5).sub.2                                                                H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        CH(OC.sub.2 H.sub.5).sub.2                                                                H   H  O OCH.sub.3                                                                            CH.sub.3 N                                        CH(SCH.sub.3).sub.2                                                                       H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       CH(SCH.sub.3).sub.2                                                                       H   H  O OCH.sub.3                                                                            CH.sub.3 CH                                       CH(SCH.sub.3).sub.2                                                                       H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       CH(SCH.sub.3).sub.2                                                                       H   H  O Cl     OCH.sub.3                                                                              CH                                       CH(SCH.sub.3).sub.2                                                                       H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        CH(SCH.sub.3).sub.2                                                                       H   H  O OCH.sub.3                                                                            CH.sub.3 N                                        C(CH.sub.3)(OCH.sub.3).sub.2                                                              H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       C(CH.sub.3)(OCH.sub.3).sub.2                                                              H   H  O CH.sub.3                                                                             i-C.sub.3 H.sub.7                                                                      CH                                       C(CH.sub.3)(OCH.sub.3).sub.2                                                              H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        C(CH.sub.3)(SCH.sub.3).sub.2                                                              H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       C(CH.sub.3)(SCH.sub.3).sub.2                                                              H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        2-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H   H  O CH.sub. 3                                                                            OCH.sub.3                                                                              N                                        dioxolan-2-yl                                                                 1,3-oxathiolan-2-yl                                                                       H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       1,3-oxathiolan-2-yl                                                                       H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        2-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       dithiolan-2-yl                                                                2-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        dithiolan-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       pyrimidin-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        pyrimidin-2-yl                                                                4,5-dimethyl-1,3-                                                                         H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 4,5-dimethyl-1,3-                                                                         H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        dioxolan-2-yl                                                                 4-ethyl-1,3-                                                                              H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 4-ethyl-1,3-                                                                              H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        dioxolan-2-yl                                                                 1,3-dimethyl-2-                                                                           H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       imidazolidinyl                                                                1,3-dimethyl-2-                                                                           H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        imidazolidinyl                                                                --C(OCH.sub.3).sub.3                                                                      H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O Cl     OCH.sub.3                                                                              CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        --C(OCH.sub.3).sub.3                                                                      H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O Cl     OCH.sub.3                                                                              CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H   H  O Cl     OCH.sub.3                                                                              CH                                       --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        __________________________________________________________________________

                                      TABLE Ie                                    __________________________________________________________________________    GENERAL STRUCTURE Ie                                                          R.sub.1     R.sub.12                                                                          R  W X      Y        Z  m.p. °C.                       __________________________________________________________________________    1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O Cl     OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCF.sub.2 H                                                                          OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.2 CH.sub.2 F                                                                 NHCH.sub.3                                                                             N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.2 CH.sub.2 F                                                                 OC.sub.2 H.sub.5                                                                       N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.2 CHF.sub.2                                                                  OCH.sub.3                                                                              N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.2 CF.sub.3                                                                   NHCH.sub.3                                                                             N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.2 CF.sub.3                                                                   N(CH.sub.3).sub.2                                                                      N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.2 CF.sub.3                                                                   OCH.sub.3                                                                              N                                        1,3-dioxolan-2-yl                                                                         H   H  O CF.sub.3                                                                             OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O I      OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O Br     OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O F      OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             OC.sub.2 H.sub.5                                                                       N                                        1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                     CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             CH.sub.2 SCH.sub.3                                                                     CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCF.sub.2 H                                                                          OCF.sub.2 H                                                                            CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            NHCH.sub.3                                                                             CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            N(OCH.sub.3)CH.sub.3                                                                   N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            C.sub.2 H.sub.5                                                                        N                                        1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             OCH.sub.2 CH.sub.2 OCH.sub.3                                                           CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            cyclopropyl                                                                            N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            SCF.sub.2 H                                                                            CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            CH(OCH.sub.3).sub.2                                                                    CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            1,3-dioxolan-2-yl                                                                      CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             OCH.sub.2 C.tbd.CH                                                                     N                                        1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             OCH.sub.2 CH═CH.sub.2                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.5                                                              N                                        1,3-dioxolan-2-yl                                                                         CH.sub.3                                                                          H  O OCH.sub.3                                                                            CH.sub.3 N                                        1,3-dioxolan-2-yl                                                                         C.sub.2 H.sub.5                                                                   H  O OCH.sub.3                                                                            CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         Cl  H  O OCH.sub.3                                                                            CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         H   CH.sub.3                                                                         O CH.sub.3                                                                             CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         H   H  S CH.sub.3                                                                             CH.sub.3 CH                                       1,3-dithiolan-2-yl                                                                        H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       1,3-dithiolan-2-yl                                                                        H   H  O OCH.sub.3                                                                            CH.sub.3 CH                                       1,3-dithiolan-2-yl                                                                        H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       1,3-dithiolan-2-yl                                                                        H   H  O Cl     OCH.sub.3                                                                              CH                                       1,3-dithiolan-2-yl                                                                        H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        1,3-dithiolan-2-yl                                                                        H   H  O OCH.sub.3                                                                            CH.sub.3 N                                        CH(OCH.sub.3).sub.2                                                                       H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       CH(OCH.sub.3).sub.2                                                                       H   H  O OCH.sub.3                                                                            CH.sub.3 CH                                       CH(OCH.sub.3).sub.2                                                                       H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       CH(OCH.sub.3).sub.2                                                                       H   H  O Cl     OCH.sub.3                                                                              CH                                       CH(OCH.sub.3).sub.2                                                                       H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        CH(OCH.sub.3).sub.2                                                                       H   H  O OCH.sub.3                                                                            CH.sub.3 N                                        CH(OC.sub.2 H.sub.5).sub.2                                                                H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       CH(OC.sub.2 H.sub.5).sub.2                                                                H   H  O OCH.sub.3                                                                            CH.sub.3 CH                                       CH(OC.sub.2 H.sub.5).sub.2                                                                H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       CH(OC.sub.2 H.sub.5).sub.2                                                                H   H  O Cl     OCH.sub.3                                                                              CH                                       CH(OC.sub.2 H.sub.5).sub.2                                                                H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        CH(OC.sub.2 H.sub.5).sub.2                                                                H   H  O OCH.sub.3                                                                            CH.sub.3 N                                        CH(SCH.sub.3).sub.2                                                                       H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       CH(SCH.sub.3).sub.2                                                                       H   H  O OCH.sub.3                                                                            CH.sub.3 CH                                       CH(SCH.sub.3).sub.2                                                                       H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       CH(SCH.sub.3).sub.2                                                                       H   H  O Cl     OCH.sub.3                                                                              CH                                       CH(SCH.sub.3).sub.2                                                                       H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        CH(SCH.sub.3).sub.2                                                                       H   H  O OCH.sub.3                                                                            CH.sub.3 N                                        C(CH.sub.3)(OCH.sub.3).sub.2                                                              H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       C(CH.sub.3)(OCH.sub.3).sub.2                                                              H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        C(CH.sub.3)(SCH.sub.3).sub.2                                                              H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       C(CH.sub.3)(SCH.sub.3).sub.2                                                              H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        2-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        dioxolan-2-yl                                                                 1,3-oxathiolan-2-yl                                                                       H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       1,3-oxathiolan-2-yl                                                                       H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        2-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       dithiolan-2-yl                                                                2-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        dithiolan-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       pyrimidin-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        pyrimidin-2-yl                                                                4,5-dimethyl-1,3-                                                                         H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 4,5-dimethyl-1,3-                                                                         H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        dioxolan-2-yl                                                                 4-ethyl-1,3-                                                                              H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 4-ethyl-1,3-                                                                              H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        dioxolan-2-yl                                                                 1,3-dimethyl-2-                                                                           H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       imidazolidinyl                                                                1,3-dimethyl-2-                                                                           H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        imidazolidinyl                                                                --C(OCH.sub.3).sub.3                                                                      H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O Cl     OCH.sub.3                                                                              CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        --C(OCH.sub.3).sub.3                                                                      H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       -- C(OC.sub.2 H.sub.5).sub.3                                                              H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O Cl     OCH.sub.3                                                                              CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H   H  O Cl     OCH.sub.3                                                                              CH                                       --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        __________________________________________________________________________

                                      TABLE II                                    __________________________________________________________________________    General Structure II                                                          R.sub.1  R.sub.11                                                                          R  W X      Y     Z  m.p. °C.                             __________________________________________________________________________    1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                          H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                             1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                          H  O CH.sub.3                                                                             OCH.sub.3                                                                           CH                                             1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                          H  O OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                             1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                          H  O Cl     OCH.sub.3                                                                           CH                                             1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                          H  O CH.sub.3                                                                             OCH.sub.3                                                                           N                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                          H  O OCH.sub.3                                                                            OCH.sub.3                                                                           N                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                          H  O OCH.sub.2 CH.sub.2 F                                                                 NHCH.sub.3                                                                          N                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                          H  O OCH.sub.2 CF.sub.3                                                                   NHCH.sub.3                                                                          N                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                          H  O OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                  CH                                             1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                          H  O OCH.sub.3                                                                            cyclo-                                                                              CH                                                                      propyl                                               1,3-dioxolan-2-yl                                                                      C.sub.3 H.sub.7                                                                   H  O OCH.sub.3                                                                            CH.sub.3                                                                            CH                                             1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                          H  S CH.sub.3                                                                             CH.sub.3                                                                            CH                                             1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                          CH.sub.3                                                                         O CH.sub.3                                                                             CH.sub.3                                                                            CH                                             CH(OCH.sub.3).sub.2                                                                    CH.sub.3                                                                          H  O OCH.sub.3                                                                            CH.sub.3                                                                            CH                                             CH(OCH.sub.3).sub.2                                                                    CH.sub.3                                                                          H  O OCH.sub.3                                                                            CH.sub.3                                                                            N                                              CH(OCH.sub.3).sub.2                                                                    CH.sub.3                                                                          H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                             CH(OCH.sub.3).sub.2                                                                    CH.sub.3                                                                          H  O Cl     OCH.sub.3                                                                           CH                                             1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                          H  O OCH.sub.3                                                                            CH.sub.3                                                                            CH                                             1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                          H  O OCH.sub.3                                                                            CH.sub.3                                                                            N                                              1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                          H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                             1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                          H  O Cl     OCH.sub.3                                                                           CH                                             --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                          H  O OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                             --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                          H  O CH.sub.3                                                                             OCH.sub.3                                                                           CH                                             --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                          H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                             --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                          H  O Cl     OCH.sub.3                                                                           CH                                             --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                          H  O CH.sub.3                                                                             OCH.sub.3                                                                           N                                              --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                          H  O OCH.sub.3                                                                            OCH.sub.3                                                                           N                                              --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                          H  O OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                             --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                          H  O CH.sub.3                                                                             OCH.sub.3                                                                           CH                                             --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                          H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                             --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                          H  O Cl     OCH.sub.3                                                                           CH                                             --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                          H  O CH.sub.3                                                                             OCH.sub.3                                                                           N                                              --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                          H  O OCH.sub.3                                                                            OCH.sub.3                                                                           N                                              __________________________________________________________________________

                                      TABLE IIa                                   __________________________________________________________________________    General Structure IIa                                                         R.sub.1  R.sub.11                                                                          R  W X      Y     Z  m.p. °C.                             __________________________________________________________________________    1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                          H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                             1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                          H  O CH.sub.3                                                                             OCH.sub.3                                                                           CH                                             1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                          H  O OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                             1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                          H  O Cl     OCH.sub.3                                                                           CH                                             1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                          H  O CH.sub.3                                                                             OCH.sub.3                                                                           N                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                          H  O OCH.sub.3                                                                            OCH.sub.3                                                                           N                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                          H  O OCH.sub.2 CH.sub.2 F                                                                 NHCH.sub.3                                                                          N                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                          H  O OCH.sub.2 CF.sub.3                                                                   NHCH.sub.3                                                                          N                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                          H  O OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                  CH                                             1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                          H  O OCH.sub.3                                                                            cyclo-                                                                              CH                                                                      propyl                                               1,3-dioxolan-2-yl                                                                      C.sub.3 H.sub.7                                                                   H  O OCH.sub.3                                                                            CH.sub.3                                                                            CH                                             1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                          H  S CH.sub.3                                                                             CH.sub.3                                                                            CH                                             1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                          CH.sub.3                                                                         O CH.sub.3                                                                             CH.sub.3                                                                            CH                                             CH(OCH.sub.3).sub.2                                                                    CH.sub.3                                                                          H  O OCH.sub.3                                                                            CH.sub.3                                                                            CH                                             CH(OCH.sub.3).sub.2                                                                    CH.sub. 3                                                                         H  O OCH.sub.3                                                                            CH.sub.3                                                                            N                                              CH(OCH.sub.3).sub.2                                                                    CH.sub.3                                                                          H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                             CH(OCH.sub.3).sub.2                                                                    CH.sub.3                                                                          H  O Cl     OCH.sub.3                                                                           CH                                             1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                          H  O OCH.sub.3                                                                            CH.sub.3                                                                            CH                                             1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                          H  O OCH.sub.3                                                                            CH.sub.3                                                                            N                                              1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                          H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                             1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                          H  O Cl     OCH.sub.3                                                                           CH                                             --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                          H  O OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                             --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                          H  O CH.sub.3                                                                             OCH.sub.3                                                                           CH                                             --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                          H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                             --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                          H  O Cl     OCH.sub.3                                                                           CH                                             --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                          H  O CH.sub.3                                                                             OCH.sub.3                                                                           N                                              --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                          H  O OCH.sub.3                                                                            OCH.sub.3                                                                           N                                              --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                          H  O OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                             --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                          H  O CH.sub.3                                                                             OCH.sub.3                                                                           CH                                             --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                          H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                             --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                          H  O Cl     OCH.sub.3                                                                           CH                                             --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                          H  O CH.sub.3                                                                             OCH.sub.3                                                                           N                                              --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                          H  O OCH.sub.3                                                                            OCH.sub.3                                                                           N                                              __________________________________________________________________________

                                      TABLE IIb                                   __________________________________________________________________________    General Structure IIb                                                         R.sub.1  R.sub.11                                                                          R  W X      Y     Z  m.p. °C.                             __________________________________________________________________________    1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                          H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                             1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                          H  O CH.sub.3                                                                             OCH.sub.3                                                                           CH                                             1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                          H  O OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                             1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                          H  O Cl     OCH.sub.3                                                                           CH                                             1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                          H  O CH.sub.3                                                                             OCH.sub.3                                                                           N                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                          H  O OCH.sub.3                                                                            OCH.sub.3                                                                           N                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                          H  O OCH.sub.2 CH.sub.2 F                                                                 NHCH.sub.3                                                                          N                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                          H  O OCH.sub.2 CF.sub.3                                                                   NHCH.sub.3                                                                          N                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                          H  O OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                  CH                                             1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                          H  O OCH.sub.3                                                                            cyclo-                                                                              CH                                                                      propyl                                               1,3-dioxolan-2-yl                                                                      C.sub.3 H.sub.7                                                                   H  O OCH.sub.3                                                                            CH.sub.3                                                                            CH                                             1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                          H  S CH.sub.3                                                                             CH.sub.3                                                                            CH                                             1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                          CH.sub.3                                                                         O CH.sub.3                                                                             CH.sub.3                                                                            CH                                             CH(OCH.sub.3).sub.2                                                                    CH.sub.3                                                                          H  O OCH.sub.3                                                                            CH.sub.3                                                                            CH                                             CH(OCH.sub.3).sub.2                                                                    CH.sub. 3                                                                         H  O OCH.sub.3                                                                            CH.sub.3                                                                            N                                              CH(OCH.sub.3).sub.2                                                                    CH.sub.3                                                                          H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                             CH(OCH.sub.3).sub.2                                                                    CH.sub.3                                                                          H  O Cl     OCH.sub.3                                                                           CH                                             1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                          H  O OCH.sub.3                                                                            CH.sub.3                                                                            CH                                             1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                          H  O OCH.sub.3                                                                            CH.sub.3                                                                            N                                              1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                          H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                             1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                          H  O Cl     OCH.sub.3                                                                           CH                                             --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                          H  O OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                             --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                          H  O CH.sub.3                                                                             OCH.sub.3                                                                           CH                                             --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                          H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                             --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                          H  O Cl     OCH.sub.3                                                                           CH                                             --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                          H  O CH.sub.3                                                                             OCH.sub.3                                                                           N                                              --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                          H  O OCH.sub.3                                                                            OCH.sub.3                                                                           N                                              --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                          H  O OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                             --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                          H  O CH.sub.3                                                                             OCH.sub.3                                                                           CH                                             --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                          H  O CH.sub.3                                                                             CH.sub. 3                                                                           CH                                             --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                          H  O Cl     OCH.sub.3                                                                           CH                                             --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                          H  O CH.sub.3                                                                             OCH.sub.3                                                                           N                                              --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                          H  O OCH.sub.3                                                                            OCH.sub.3                                                                           N                                              __________________________________________________________________________

                                      TABLE IIc                                   __________________________________________________________________________    General Structure IIc                                                         R.sub.1  R.sub.11                                                                         R  W X      Y     Z  m.p. °C.                              __________________________________________________________________________    1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O CH.sub.3                                                                             OCH.sub.3                                                                           CH                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O Cl     OCH.sub.3                                                                           CH                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O CH.sub.3                                                                             OCH.sub.3                                                                           N                                               1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O OCH.sub.3                                                                            OCH.sub.3                                                                           N                                               1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O OCH.sub.2 CH.sub.2 F                                                                 NHCH.sub.3                                                                          N                                               1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O OCH.sub.2 CF.sub.3                                                                   NHCH.sub.3                                                                          N                                               1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                  CH                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O OCH.sub.3                                                                            cyclo-                                                                              CH                                                                      propyl                                                1,3-dioxolan-2-yl                                                                      C.sub.3 H.sub.7                                                                  H  O OCH.sub.3                                                                            CH.sub.3                                                                            CH                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  S CH.sub.3                                                                             CH.sub.3                                                                            CH                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         CH.sub.3                                                                         O CH.sub.3                                                                             CH.sub.3                                                                            CH                                              CH(OCH.sub.3).sub.2                                                                    CH.sub.3                                                                         H  O OCH.sub.3                                                                            CH.sub.3                                                                            CH                                              CH(OCH.sub.3).sub.2                                                                    CH.sub.3                                                                         H  O OCH.sub.3                                                                            CH.sub.3                                                                            N                                               CH(OCH.sub. 3).sub.2                                                                   CH.sub.3                                                                         H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                              CH(OCH.sub.3).sub.2                                                                    CH.sub.3                                                                         H  O Cl     OCH.sub.3                                                                           CH                                              1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                         H  O OCH.sub.3                                                                            CH.sub.3                                                                            CH                                              1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                         H  O OCH    CH.sub.3                                                                            N                                               1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                         H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                              1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                         H  O Cl     OCH.sub.3                                                                           CH                                              1,3 C(OCH.sub.3).sub.3                                                                 CH.sub.3                                                                         H  O OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                              1,3 C(OCH.sub.3).sub.3                                                                 CH.sub.3                                                                         H  O CH.sub.3                                                                             OCH.sub.3                                                                           CH                                              --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                         H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                              --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                         H  O Cl     OCH.sub.3                                                                           CH                                              --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                         H  O CH.sub.3                                                                             OCH.sub.3                                                                           N                                               --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                         H  O CH.sub.3                                                                             OCH.sub.3                                                                           N                                               --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                         H  O OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                              --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                         H  O CH.sub.3                                                                             OCH.sub.3                                                                           CH                                              --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                         H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                              --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                         H  O Cl     OCH.sub.3                                                                           CH                                              --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                         H  O CH.sub.3                                                                             OCH.sub.3                                                                           N                                               --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                         H  O OCH.sub.3                                                                            OCH.sub.3                                                                           N                                               __________________________________________________________________________

                                      TABLE III                                   __________________________________________________________________________    General Structure III                                                         R.sub.1   R  W X      Y     Z  m.p. °C.                                __________________________________________________________________________    1,3-dioxolan-2-yl                                                                       H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                                1,3-dioxolan-2-yl                                                                       H  O CH.sub.3                                                                             OCH.sub.3                                                                           CH                                                1,3-dioxolan-2-yl                                                                       H  O OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                                1,3-dioxolan-2-yl                                                                       H  O Cl     OCH.sub.3                                                                           CH                                                1,3-dioxolan-2-yl                                                                       H  O CH.sub.3                                                                             OCH.sub.3                                                                           N                                                 1,3-dioxolan-2-yl                                                                       H  O OCH.sub.3                                                                            OCH.sub.3                                                                           N                                                 1,3-dioxolan-2-yl                                                                       H  O OCH.sub.2 CH.sub.2 F                                                                 NHCH.sub.3                                                                          N                                                 1,3-dioxolan-2-yl                                                                       H  O OCH.sub.2 CF.sub.3                                                                   NHCH.sub.3                                                                          N                                                 1,3-dioxolan-2-yl                                                                       H  O OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                  CH                                                1,3-dioxolan-2-yl                                                                       H  O OCH.sub.3                                                                            cyclo-                                                                              CH                                                                      propyl                                                  1,3-dioxolan-2-yl                                                                       H  O OCH.sub.3                                                                            CH.sub.3                                                                            CH                                                1,3-dioxolan-2-yl                                                                       H  S CH.sub.3                                                                             CH.sub.3                                                                            CH                                                1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                         O CH.sub.3                                                                             CH.sub.3                                                                            CH                                                CH(OCH.sub.3).sub.2                                                                     H  O OCH.sub.3                                                                            CH.sub.3                                                                            CH                                                CH(OCH.sub.3).sub.2                                                                     H  O OCH.sub.3                                                                            CH.sub.3                                                                            N                                                 CH(OCH.sub.3).sub.2                                                                     H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                                CH(OCH.sub.3).sub.2                                                                     H  O Cl     OCH.sub.3                                                                           CH                                                1,3-dithiolan-2-yl                                                                      H  O OCH.sub.3                                                                            CH.sub.3                                                                            CH                                                1,3-dithiolan-2-yl                                                                      H  O OCH.sub.3                                                                            CH.sub.3                                                                            N                                                 1,3-dithiolan-2-yl                                                                      H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                                1,3-dithiolan-2-yl                                                                      H  O Cl     OCH.sub.3                                                                           CH                                                --C(OCH.sub.3).sub.3                                                                    H  O OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                                --C(OCH.sub.3).sub.3                                                                    H  O CH.sub.3                                                                             OCH.sub.3                                                                           CH                                                --C(OCH.sub.3).sub.3                                                                    H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                                --C(OCH.sub.3).sub.3                                                                    H  O Cl     OCH.sub.3                                                                           CH                                                --C(OCH.sub.3).sub.3                                                                    H  O CH.sub.3                                                                             OCH.sub.3                                                                           N                                                 --C(OCH.sub.3).sub.3                                                                    H  O OCH.sub.3                                                                            OCH.sub.3                                                                           N                                                 --C(OC.sub.2 H.sub.5).sub.3                                                             H  O OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                                --C(OC.sub.2 H.sub.5).sub.3                                                             H  O CH.sub.3                                                                             OCH.sub.3                                                                           CH                                                --C(OC.sub.2 H.sub.5).sub.3                                                             H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                                --C(OC.sub.2 H.sub.5).sub.3                                                             H  O Cl     OCH.sub.3                                                                           CH                                                --C(OC.sub.2 H.sub.5).sub.3                                                             H  O CH.sub.3                                                                             OCH.sub.3                                                                           N                                                 --C(OC.sub.2 H.sub.5).sub.3                                                             H  O OCH.sub.3                                                                            OCH.sub.3                                                                           N                                                 __________________________________________________________________________

                                      TABLE IIIa                                  __________________________________________________________________________    General Structure IIIa                                                        R.sub.1   R  W X      Y     Z  m.p. °C.                                __________________________________________________________________________    1,3-dioxolan-2-yl                                                                       H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                                1,3-dioxolan-2-yl                                                                       H  O CH.sub.3                                                                             OCH.sub.3                                                                           CH                                                1,3-dioxolan-2-yl                                                                       H  O OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                                1,3-dioxolan-2-yl                                                                       H  O Cl     OCH.sub.3                                                                           CH                                                1,3-dioxolan-2-yl                                                                       H  O CH.sub.3                                                                             OCH.sub.3                                                                           N                                                 1,3-dioxolan-2-yl                                                                       H  O OCH.sub.3                                                                            OCH.sub.3                                                                           N                                                 1,3-dioxolan-2-yl                                                                       H  O OCH.sub.2 CH.sub.2 F                                                                 NHCH.sub.3                                                                          N                                                 1,3-dioxolan-2-yl                                                                       H  O OCH.sub.2 CF.sub.3                                                                   NHCH.sub.3                                                                          N                                                 1,3-dioxolan-2-yl                                                                       H  O OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                  CH                                                1,3-dioxolan-2-yl                                                                       H  O OCH.sub.3                                                                            cyclo-                                                                              CH                                                                      propyl                                                  1,3-dioxolan-2-yl                                                                       H  O OCH.sub.3                                                                            CH.sub.3                                                                            CH                                                1,3-dioxolan-2-yl                                                                       H  S CH.sub.3                                                                             CH.sub.3                                                                            CH                                                1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                         O CH.sub.3                                                                             CH.sub.3                                                                            CH                                                CH(OCH.sub.3).sub.2                                                                     H  O OCH.sub.3                                                                            CH.sub.3                                                                            CH                                                CH(OCH.sub.3).sub.2                                                                     H  O OCH.sub.3                                                                            CH.sub.3                                                                            N                                                 CH(OCH.sub.3).sub.2                                                                     H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                                CH(OCH.sub.3).sub.2                                                                     H  O Cl     OCH.sub.3                                                                           CH                                                1,3-dithiolan-2-yl                                                                      H  O OCH.sub.3                                                                            CH.sub.3                                                                            CH                                                1,3-dithiolan-2-yl                                                                      H  O OCH.sub.3                                                                            CH.sub.3                                                                            N                                                 1,3-dithiolan-2-yl                                                                      H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                                1,3-dithiolan-2-yl                                                                      H  O Cl     OCH.sub.3                                                                           CH                                                --C(OCH.sub.3).sub.3                                                                    H  O OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                                --C(OCH.sub.3).sub.3                                                                    H  O CH.sub.3                                                                             OCH.sub.3                                                                           CH                                                --C(OCH.sub.3).sub.3                                                                    H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                                --C(OCH.sub.3).sub.3                                                                    H  O Cl     OCH.sub.3                                                                           CH                                                --C(OCH.sub.3).sub.3                                                                    H  O CH.sub.3                                                                             OCH.sub.3                                                                           N                                                 --C(OCH.sub.3).sub.3                                                                    H  O OCH.sub.3                                                                            OCH.sub.3                                                                           N                                                 --C(OC.sub.2 H.sub.5).sub.3                                                             H  O OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                                --C(OC.sub.2 H.sub.5).sub.3                                                             H  O CH.sub.3                                                                             OCH.sub.3                                                                           CH                                                --C(OC.sub.2 H.sub.5).sub.3                                                             H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                                --C(OC.sub.2 H.sub.5).sub.3                                                             H  O Cl     OCH.sub.3                                                                           CH                                                --C(OC.sub.2 H.sub.5).sub.3                                                             H  O CH.sub.3                                                                             OCH.sub.3                                                                           N                                                 --C(OC.sub.2 H.sub.5).sub.3                                                             H  O OCH.sub.3                                                                            OCH.sub.3                                                                           N                                                 __________________________________________________________________________

                                      TABLE IIIb                                  __________________________________________________________________________    General Structure IIIb                                                        R.sub.1   R  W X      Y     Z  m.p. °C.                                __________________________________________________________________________    1,3-dioxolar-2-yl                                                                       H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                                1,3-dioxolan-2-yl                                                                       H  O CH.sub.3                                                                             OCH.sub.3                                                                           CH                                                1,3-dioxolan-2-yl                                                                       H  O OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                                1,3-dioxolan-2-yl                                                                       H  O Cl     OCH.sub.3                                                                           CH                                                1,3-dioxolan-2-yl                                                                       H  O CH.sub.3                                                                             OCH.sub.3                                                                           N                                                 1,3-dioxolan-2-yl                                                                       H  O OCH.sub.3                                                                            OCH.sub.3                                                                           N                                                 1,3-dioxolan-2-yl                                                                       H  O OCH.sub.2 CH.sub.2 F                                                                 NHCH.sub.3                                                                          N                                                 1,3-dioxolan-2-yl                                                                       H  O OCH.sub.2 CF.sub.3                                                                   NHCH.sub.3                                                                          N                                                 1,3-dioxolan-2-yl                                                                       H  O OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                  CH                                                1,3-dioxolan-2-yl                                                                       H  O OCH.sub.3                                                                            cyclo-                                                                              CH                                                                      propyl                                                  1,3-dioxolan-2-yl                                                                       H  O OCH.sub.3                                                                            CH.sub.3                                                                            CH                                                1,3-dioxolan-2-yl                                                                       H  S CH.sub.3                                                                             CH.sub.3                                                                            CH                                                1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                         O CH.sub.3                                                                             CH.sub.3                                                                            CH                                                CH(OCH.sub.3).sub.2                                                                     H  O OCH.sub.3                                                                            CH.sub.3                                                                            CH                                                CH(OCH.sub.3).sub.2                                                                     H  O OCH.sub.3                                                                            CH.sub.3                                                                            N                                                 CH(OCH.sub.3).sub.2                                                                     H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                                CH(OCH.sub.3).sub.2                                                                     H  O Cl     OCH.sub.3                                                                           CH                                                1,3-dithiolan-2-yl                                                                      H  O OCH.sub.3                                                                            CH.sub.3                                                                            CH                                                1,3-dithiolan-2-yl                                                                      H  O OCH.sub. 3                                                                           CH.sub.3                                                                            N                                                 1,3-dithiolan-2-yl                                                                      H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                                1,3-dithiolan-2-yl                                                                      H  O Cl     OCH.sub.3                                                                           CH                                                --C(OCH.sub.3).sub.3                                                                    H  O OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                                --C(OCH.sub.3).sub.3                                                                    H  O CH.sub.3                                                                             OCH.sub.3                                                                           CH                                                --C(OCH.sub.3).sub.3                                                                    H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                                --C(OCH.sub.3).sub.3                                                                    H  O Cl     OCH.sub.3                                                                           CH                                                --C(OCH.sub.3).sub.3                                                                    H  O CH.sub.3                                                                             OCH.sub.3                                                                           N                                                 --C(OCH.sub.3).sub.3                                                                    H  O OCH.sub.3                                                                            OCH.sub.3                                                                           N                                                 --C(OC.sub.2 H.sub.5).sub.3                                                             H  O OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                                --C(OC.sub.2 H.sub.5).sub.3                                                             H  O CH.sub.3                                                                             OCH.sub.3                                                                           CH                                                --C(OC.sub.2 H.sub.5).sub.3                                                             H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                                --C(OC.sub.2 H.sub.5).sub.3                                                             H  O Cl     OCH.sub.3                                                                           CH                                                --C(OC.sub.2 H.sub.5).sub.3                                                             H  O CH.sub.3                                                                             OCH.sub.3                                                                           N                                                 --C(OC.sub.2 H.sub.5).sub.3                                                             H  O OCH.sub.3                                                                            OCH.sub.3                                                                           N                                                 __________________________________________________________________________

                                      TABLE IV                                    __________________________________________________________________________    General Structure IV                                                          R.sub.1  R.sub.2                                                                         R W W.sub.1                                                                          A             Y.sub.2                                                                          Z  m.p. °C.                         __________________________________________________________________________                         X.sub.1                                                                             Y.sub.1                                            1,3-dioxolan-2-yl                                                                      H H O S  A-2                                                                              CH.sub.3                                                                            O    --                                            1,3-dioxolan-2-yl                                                                      H H O S  A-2                                                                              OCH.sub.3                                                                           O    --                                            1,3-dioxolan-2-yl                                                                      H H O S  A-2                                                                              OCF.sub.2 H                                                                         O    --                                            1,3-dioxolan-2-yl                                                                      H H O S  A-2                                                                              CH.sub.3                                                                            CH.sub.2                                                                           --                                            1,3-dioxolan-2-yl                                                                      H H O S  A-2                                                                              OCH.sub.3                                                                           CH.sub.2                                                                           --                                            1,3-dioxolan-2-yl                                                                      H H O S  A-2                                                                              OC.sub.2 H.sub.5                                                                    CH.sub.2                                                                           --                                            1,3-dioxolan-2-yl                                                                      H H O O  A-2                                                                              CH.sub.3                                                                            O    --                                            1,3-dioxolan-2-yl                                                                      H H O O  A-2                                                                              OCH.sub.3                                                                           O    --                                            1,3-dioxolan-2-yl                                                                      H H O O  A-2                                                                              OCH.sub.3                                                                           CH.sub.2                                                                           --                                            1,3-dithiolan-2-yl                                                                     H H O S  A-2                                                                              CH.sub.3                                                                            O    --                                            1,3-dithiolan-2-yl                                                                     H H O S  A-2                                                                              OCH.sub.3                                                                           CH.sub.2                                                                           --                                            1,3-dithiolan-2-yl                                                                     H H O O  A-2                                                                              CH.sub.3                                                                            O    --                                            1,3-dithiolan-2-yl                                                                     H H O O  A-2                                                                              OCH.sub.3                                                                           CH.sub.2                                                                           --                                            CH(OCH.sub.3).sub.2                                                                    H H O S  A-2                                                                              CH.sub.3                                                                            O    --                                            CH(OCH.sub.3).sub.2                                                                    H H O O  A-2                                                                              CH.sub.3                                                                            O    --                                            1,3-dioxolan-2-yl                                                                      H H O S  A-3                                                                              CH.sub.3                                                                            --   --                                            1,3-dioxolan-2-yl                                                                      H H O S  A-3                                                                              OCH   --   --                                            1,3-dioxolan-2-yl                                                                      H H O O  A-3                                                                              OCF.sub.2 H                                                                         --   --                                            1,3-dioxolan-2-yl                                                                      H H O S  A-4                                                                              OCH.sub.3                                                                           --   CH.sub.3                                      1,3-dioxolan-2-yl                                                                      H H O S  A-4                                                                              CH.sub.3                                                                            --   CH.sub.3                                      1,3-dioxolan-2-yl                                                                      H H O S  A-4                                                                              OC.sub.2 H.sub.5                                                                    --   H                                             1,3-dioxolan-2-yl                                                                      H H O O  A-4                                                                              CH.sub.3                                                                            --   CH.sub.3                                      1,3-dioxolan-2-yl                                                                      H H O O  A-4                                                                              OCF.sub.2 H                                                                         --   CH.sub.3                                      1,3-dithiolan-2-yl                                                                     H H O S  A-3                                                                              CH.sub.3                                                                            --   --                                            1,3-dithiolan-2-yl                                                                     H H O S  A-4                                                                              CH.sub.3                                                                            --   CH.sub.3                                      CH(OCH.sub.3).sub.2                                                                    H H O S  A-3                                                                              OCH.sub.3                                                                           --   --                                            CH(OCH.sub.3).sub.2                                                                    H H O S  A-4                                                                              OCH.sub.3                                                                           --   CH.sub.3                                      C(OCH.sub.3).sub.3                                                                     H H O S  A-2                                                                              CH.sub.3                                                                            O    --                                            C(OCH.sub. 3).sub.3                                                                    H H O S  A-2                                                                              OCH.sub.3                                                                           O    --                                            C(OCH.sub.3).sub.3                                                                     H H O S  A-2                                                                              OCF.sub.2 H                                                                         O    --                                            C(OCH.sub.3).sub.3                                                                     H H O S  A-2                                                                              CH.sub.3                                                                            CH.sub.2                                                                           --                                            C(OCH.sub.3).sub.3                                                                     H H O S  A-2                                                                              OCH.sub.3                                                                           CH.sub.2                                                                           --                                            C(OCH.sub.3).sub.3                                                                     H H O S  A-2                                                                              OC.sub.2 H.sub.5                                                                    CH.sub.2                                                                           --                                            C(OCH.sub.3).sub.3                                                                     H H O O  A-3                                                                              CH.sub.3                                                                            --   --                                            C(OCH.sub.3).sub.3                                                                     H H O O  A-3                                                                              OCH.sub.3                                                                           --   --                                            C(OCH.sub.3).sub.3                                                                     H H O O  A-3                                                                              OCF.sub.2 H                                                                         --   --                                            C(OCH.sub.3).sub.3                                                                     H H O O  A-4                                                                              OCH.sub.3                                                                           --   CH.sub.3                                      C(OCH.sub.3).sub.3                                                                     H H O O  A-4                                                                              CH.sub.3                                                                            --   CH.sub.3                                      C(OCH.sub.3).sub.3                                                                     H H O O  A-4                                                                              OC.sub.2 H.sub.5                                                                    --   H                                             C(OCH.sub.3).sub.3                                                                     H H O O  A-4                                                                              OCF.sub.2 H                                                                         --   CH.sub.3                                      C(OCH.sub.3).sub.3                                                                     H H O O  A-2                                                                              CH.sub.3                                                                            O    --                                            C(OC.sub.2 H.sub. 5).sub.3                                                             H H O O  A-2                                                                              CH.sub.3                                                                            O    --                                            C(OC.sub.2 H.sub.5).sub.3                                                              H H O S  A-2                                                                              CH.sub.3                                                                            O    --                                                                 X.sub.2                                                                             Y.sub.3                                            C(OCH.sub.3).sub.3                                                                     H H O S  A-5                                                                              CH.sub.3                                                                            OCH.sub.3                                          C(OCH.sub.3).sub.3                                                                     H H O S  A-5                                                                              CH.sub.3                                                                            OC.sub.2 H.sub.5                                   C(OCH.sub.3).sub.3                                                                     H H O S  A-5                                                                              CH.sub.3                                                                            SCH.sub.3                                          C(OCH.sub.3).sub.3                                                                     H H O S  A-5                                                                              CH.sub.3                                                                            SC.sub.2 H.sub.5                                   C(OCH.sub.3).sub.3                                                                     H H O S  A-5                                                                              CH.sub.3                                                                            CH.sub.3                                           C(OCH.sub.3).sub.3                                                                     H H O S  A-5                                                                              CH.sub.3                                                                            C.sub.2 H.sub.5                                    C(OCH.sub.3).sub.3                                                                     H H O S  A-5                                                                              CH.sub.3                                                                            OCF.sub.2 H                                        C(OCH.sub.3).sub.3                                                                     H H O S  A-5                                                                              CH.sub.3                                                                            SCF.sub.2 H                                        C(OCH.sub.3).sub.3                                                                     H H O S  A-5                                                                              C.sub.2 H.sub.5                                                                     OCH.sub.3                                          C(OCH.sub.3).sub.3                                                                     H H O S  A-5                                                                              CH.sub.2 CF.sub.3                                                                   OCH.sub.3                                          C(OCH.sub.3).sub.3                                                                     H H O O  A-5                                                                              CH.sub.3                                                                            OCH.sub.3                                          1,3-dioxolan-2-yl                                                                      H H O S  A-5                                                                              CH.sub.3                                                                            OCH.sub.3                                                                          --                                            1,3-dioxolan-2-yl                                                                      H H O S  A-5                                                                              CH.sub.3                                                                            OC.sub.2 H.sub.5                                                                   --                                            1,3-dioxolan-2-yl                                                                      H H O S  A-5                                                                              CH.sub.3                                                                            SCH.sub.3                                                                          --                                            1,3-dioxolan-2-yl                                                                      H H O S  A-5                                                                              CH.sub.3                                                                            SC.sub.2 H.sub.5                                                                   --                                            1,3-dioxolan-2-yl                                                                      H H O S  A-5                                                                              CH.sub.3                                                                            OCF.sub.2 H                                                                        --                                            1,3-dioxolan-2-yl                                                                      H H O S  A-5                                                                              CH.sub.3                                                                            SCF.sub.2 H                                                                        --                                            CH(OCH.sub.3).sub.2                                                                    H H O S  A-5                                                                              CH.sub.3                                                                            OCH.sub.3                                                                          --                                            CH(OCH.sub.3).sub.2                                                                    H H O S  A-5                                                                              CH.sub.3                                                                            OC.sub.2 H.sub.5                                                                   --                                            CH(OCH.sub.3).sub.2                                                                    H H O S  A-5                                                                              CH.sub.3                                                                            SCH.sub.3                                                                          --                                            CH(OCH.sub.3).sub.2                                                                    H H O S  A-5                                                                              CH.sub.3                                                                            SC.sub.2 H.sub.5                                                                   --                                            CH(OCH.sub.3).sub.2                                                                    H H O S  A-5                                                                              CH.sub.3                                                                            OCF.sub.2 H                                                                        --                                            CH(OCH.sub.3).sub.2                                                                    H H O S  A-5                                                                              CH.sub.3                                                                            SCF.sub.2 H                                                                        --                                            CH(OCH.sub.3).sub.2                                                                    H H O S  A-5                                                                              CH.sub.3                                                                            OCH.sub.3                                                                          --                                                                 X.sub.3                                                  C(OCH.sub.3).sub.3                                                                     H H O S  A-6                                                                              CH.sub.3                                                                            --   --                                            C(OCH.sub.3).sub.3                                                                     H H O S  A-6                                                                              OCH.sub.3                                                                           --   --                                            1,3-dioxolan-2-yl                                                                      H H O S  A-6                                                                              CH.sub.3                                                                            --   --                                            1,3-dioxolan-2-yl                                                                      H H O S  A-6                                                                              OCH.sub.3                                                                           --   --                                            CH(OCH.sub.3).sub.2                                                                    H H O S  A-6                                                                              CH.sub.3                                                                            --   --                                            CH(OCH.sub.3).sub.2                                                                    H H O S  A-6                                                                              OCH.sub.3                                                                           --   --                                            CH(OCH.sub.3).sub.2                                                                    H H O O  A-6                                                                              CH.sub.3                                                                            --   --                                                                 X.sub.4                                                                             Y.sub.4                                            CH(OCH.sub.3).sub.2                                                                    H H O S  A-7                                                                              CH.sub.3                                                                            CH.sub.3                                                                              CH                                         CH(OCH.sub.3).sub.2                                                                    H H O S  A-7                                                                              OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                         1,3-dioxolan-2-yl                                                                      H H O S  A-7                                                                              CH.sub.3                                                                            CH.sub.3                                                                              CH                                         1,3-dioxolan-2-yl                                                                      H H O S  A-7                                                                              OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                         C(OCH.sub.3).sub.3                                                                     H H O S  A-7                                                                              CH.sub.3                                                                            CH.sub.3                                                                              CH                                         C(OCH.sub.3).sub.3                                                                     H H O S  A-7                                                                              CH.sub.3                                                                            CH.sub.3                                                                              N                                          C(OCH.sub.3).sub.3                                                                     H H O S  A-7                                                                              OCH.sub.3                                                                           CH.sub.3                                                                              CH                                         C(OCH.sub. 3).sub.3                                                                    H H O S  A-7                                                                              OCH.sub.3                                                                           CH.sub.3                                                                              N                                          C(OCH.sub.3).sub.3                                                                     H H O S  A-7                                                                              OCH.sub.3                                                                           OCH.sub.3                                                                             N                                          C(OCH.sub.3).sub.3                                                                     H H O S  A-7                                                                              Cl    CH.sub.3                                                                              CH                                         C(OCH.sub.3).sub.3                                                                     H H O S  A-7                                                                              OCH.sub.3                                                                           Cl      CH                                         C(OCH.sub.3).sub.3                                                                     H H O S  A-7                                                                              OC.sub.2 H.sub.5                                                                    CH.sub.3                                                                              CH                                         C(OCH.sub.3).sub.3                                                                     H H O S  A-7                                                                              CH.sub.2 OCH.sub.3                                                                  CH.sub.3                                                                              N                                          C(OCH.sub.3).sub.3                                                                     H H O S  A-7                                                                              CH.sub.2 OCH.sub.3                                                                  OCH.sub.3                                                                             CH                                         C(OCH.sub.3).sub.3                                                                     H H O S  A-7                                                                              OC.sub.2 H.sub.5                                                                    OC.sub.2 H.sub.5                                                                      N                                          C(OCH.sub.3).sub.3                                                                     H H O O  A-7                                                                              CH.sub.3                                                                            CH.sub.3                                                                              CH                                         __________________________________________________________________________

                                      TABLE IVa                                   __________________________________________________________________________    General Structure IVa                                                         R.sub.1  R.sub.12                                                                         R W W.sub.1                                                                          A             Y.sub.2                                                                          Z  m.p. °C.                        __________________________________________________________________________                          X.sub.1                                                                             Y.sub.1                                           1,3-dioxolan-2-yl                                                                      H  H O S  A-2                                                                              CH.sub.3                                                                            O    --                                           1,3-dioxolan-2-yl                                                                      H  H O S  A-2                                                                              OCH.sub.3                                                                           O    --                                           1,3-dioxolan-2-yl                                                                      H  H O S  A-2                                                                              OCF.sub.2 H                                                                         O    --                                           1,3-dioxolan-2-yl                                                                      H  H O S  A-2                                                                              CH.sub.3                                                                            CH.sub.2                                                                           --                                           1,3-dioxolar-2-yl                                                                      H  H O S  A-2                                                                              OCH.sub.3                                                                           CH.sub.2                                                                           --                                           1,3-dioxolan-2-yl                                                                      H  H O S  A-2                                                                              OC.sub.2 H.sub.5                                                                    CH.sub.2                                                                           --                                           1,3-dioxolan-2-yl                                                                      H  H O O  A-2                                                                              CH.sub.3                                                                            O    --                                           1,3-dioxolan-2-yl                                                                      H  H O O  A-2                                                                              OCH.sub.3                                                                           O    --                                           1,3-dioxolan-2-yl                                                                      H  H O O  A-2                                                                              OCH.sub.3                                                                           CH.sub.2                                                                           --                                           1,3-dithiolan-2-yl                                                                     H  H O S  A-2                                                                              CH.sub.3                                                                            O    --                                           1,3-dithiolan-2-yl                                                                     H  H O S  A-2                                                                              OCH.sub.3                                                                           CH   --                                           1,3-dithiolan-2-yl                                                                     H  H O O  A-2                                                                              CH.sub.3                                                                            O    --                                           1,3-dithiolan-2-yl                                                                     H  H O O  A-2                                                                              OCH.sub.3                                                                           CH   --                                           CH(OCH.sub.3).sub.2                                                                    H  H O S  A-2                                                                              CH.sub.3                                                                            O    --                                           CH(OCH.sub.3).sub.2                                                                    H  H O O  A-2                                                                              CH.sub.3                                                                            O    --                                           1,3-dioxolan-2-yl                                                                      H  H O S  A-3                                                                              CH.sub.3                                                                            --   --                                           1,3-dioxolan-2-yl                                                                      H  H O S  A-3                                                                              OCH.sub.3                                                                           --   --                                           1,3-dioxolan-2-yl                                                                      H  H O S  A-3                                                                              OCF.sub.2 H                                                                         --   --                                           1,3-dioxolan-2-yl                                                                      H  H O S  A-4                                                                              OCH.sub.3                                                                           --   CH.sub.3                                     1,3-dioxolan-2-yl                                                                      H  H O S  A-4                                                                              CH.sub.3                                                                            --   CH.sub.3                                     1,3-dioxolan-2-yl                                                                      H  H O S  A-4                                                                              OC.sub.2 H.sub.5                                                                    --   H                                            1,3-dioxolan-2-yl                                                                      H  H O O  A-4                                                                              CH.sub.3                                                                            --   CH.sub.3                                     1,3-dioxolan-2-yl                                                                      H  H O O  A-4                                                                              OCF.sub.2 H                                                                         --   CH.sub.3                                     1,3-dithiolan-2-yl                                                                     H  H O S  A-3                                                                              CH.sub.3                                                                            --   --                                           1,3-dithiolan-2-yl                                                                     H  H O S  A-4                                                                              CH.sub.3                                                                            --   CH.sub.3                                     CH(OCH.sub.3).sub.2                                                                    H  H O S  A-3                                                                              OCH.sub.3                                                                           --   --                                           CH(OCH.sub.3).sub.2                                                                    H  H O S  A-4                                                                              OCH.sub.3                                                                           --   CH.sub.3                                     C(OCH.sub.3).sub.3                                                                     H  H O S  A-2                                                                              CH.sub.3                                                                            O    --                                           C(OCH.sub.3).sub. 3                                                                    H  H O S  A-2                                                                              OCH.sub.3                                                                           O    --                                           C(OCH.sub.3).sub.3                                                                     H  H O S  A-2                                                                              OCF.sub.2 H                                                                         O    --                                           C(OCH.sub.3).sub.3                                                                     H  H O S  A-2                                                                              CH.sub.3                                                                            CH.sub.2                                                                           --                                           C(OCH.sub.3).sub.3                                                                     H  H O S  A-2                                                                              OCH.sub.3                                                                           CH.sub.2                                                                           --                                           C(OCH.sub.3).sub.3                                                                     H  H O S  A-2                                                                              OC.sub.2 H.sub.5                                                                    CH.sub.2                                                                           --                                           C(OCH.sub.3).sub.3                                                                     H  H O O  A-3                                                                              CH.sub.3                                                                            --   --                                           C(OCH.sub.3).sub.3                                                                     H  H O O  A-3                                                                              OCH.sub.3                                                                           --   --                                           C(OCH.sub.3).sub.3                                                                     H  H O O  A-3                                                                              OCF.sub.2 H                                                                         --   --                                           C(OCH.sub.3).sub.3                                                                     H  H O O  A-4                                                                              OCH.sub.3                                                                           --   CH.sub.3                                     C(OCH.sub.3).sub.3                                                                     H  H O O  A-4                                                                              CH.sub.3                                                                            --   CH.sub.3                                     C(OCH.sub.3).sub.3                                                                     H  H O O  A-4                                                                              OC.sub.2 H.sub.5                                                                    --   H                                            C(OCH.sub.3).sub.3                                                                     H  H O O  A-4                                                                              OCF.sub.2 H                                                                         --   CH.sub.3                                     C(OCH.sub.3).sub.3                                                                     H  H O O  A-2                                                                              CH.sub.3                                                                            O    --                                           C(OC.sub.2 H.sub.5).sub.3                                                              H  H O S  A-2                                                                              CH.sub.3                                                                            O    --                                           C(OC.sub.2 H.sub.5).sub.3                                                              H  H O S  A-2                                                                              CH.sub.3                                                                            O    --                                                                 X.sub.2                                                                             Y.sub.3                                           C(OCH.sub.3).sub.3                                                                     H  H O S  A-5                                                                              CH.sub.3                                                                            OCH.sub.3                                         C(OCH.sub.3).sub.3                                                                     H  H O S  A-5                                                                              CH.sub.3                                                                            OC.sub.2 H.sub.5                                  C(OCH.sub.3).sub.3                                                                     H  H O S  A-5                                                                              CH.sub.3                                                                            SCH.sub.3                                         C(OCH.sub.3).sub.3                                                                     H  H O S  A-5                                                                              CH.sub.3                                                                            SC.sub.2 H.sub.5                                  C(OCH.sub.3).sub.3                                                                     H  H O S  A-5                                                                              CH.sub.3                                                                            CH.sub.3                                          C(OCH.sub.3).sub.3                                                                     H  H O S  A-5                                                                              CH.sub.3                                                                            C.sub.2 H.sub.5                                   C(OCH.sub.3).sub.3                                                                     H  H O S  A-5                                                                              CH.sub.3                                                                            OCF.sub.2 H                                       C(OCH.sub.3).sub.3                                                                     H  H O S  A-5                                                                              CH.sub.3                                                                            SCF.sub.2 H                                       C(OCH.sub.3).sub.3                                                                     H  H O S  A-5                                                                              C.sub.2 H.sub.5                                                                     OCH.sub.3                                         C(OCH.sub.3).sub.3                                                                     H  H O S  A-5                                                                              CH.sub.2 CF.sub.3                                                                   OCH.sub.3                                         C(OCH.sub.3).sub.3                                                                     H  H O O  A-5                                                                              CH.sub.3                                                                            OCH.sub.3                                         1,3-dioxolan-2-yl                                                                      H  H O S  A-5                                                                              CH.sub. 3                                                                           OCH.sub.3                                                                          --                                           1,3-dioxolan-2-yl                                                                      H  H O S  A-5                                                                              CH.sub.3                                                                            OC.sub.2 H.sub.5                                                                   --                                           1,3-dioxolan-2-yl                                                                      H  H O S  A-5                                                                              CH.sub.3                                                                            SCH.sub.3                                                                          --                                           1,3-dioxolan-2-yl                                                                      H  H O S  A-5                                                                              CH.sub.3                                                                            SC.sub.2 H.sub.5                                                                   --                                           1,3-dioxolan-2-yl                                                                      H  H O S  A-5                                                                              CH.sub.3                                                                            OCF.sub.2 H                                                                        --                                           1,3-dioxolan-2-yl                                                                      H  H O S  A-5                                                                              CH.sub.3                                                                            SCF.sub.2 H                                                                        --                                           CH(OCH.sub.3).sub.2                                                                    H  H O S  A-5                                                                              CH.sub.3                                                                            OCH.sub.3                                                                          --                                           CH(OCH.sub.3).sub.2                                                                    H  H O S  A-5                                                                              CH.sub.3                                                                            OC.sub.2 H.sub.5                                                                   --                                           CH(OCH.sub.3).sub.2                                                                    H  H O S  A-5                                                                              CH.sub.3                                                                            SCH.sub.3                                                                          --                                           CH(OCH.sub.3).sub.2                                                                    H  H O S  A-5                                                                              CH.sub.3                                                                            SC.sub.2 H.sub.5                                                                   --                                           CH(OCH.sub.3).sub.2                                                                    H  H O S  A-5                                                                              CH.sub.3                                                                            OCF.sub.2 H                                                                        --                                           CH(OCH.sub.3).sub.2                                                                    H  H O S  A-5                                                                              CH.sub.3                                                                            SCF.sub.2 H                                                                        --                                           CH(OCH.sub.3).sub.2                                                                    H  H O O  A-5                                                                              CH.sub.3                                                                            OCH.sub.3                                                                          --                                                                 X.sub.3                                                 C(OCH.sub.3).sub.3                                                                     H  H O S  A-6                                                                              CH.sub.3                                                                            --   --                                           C(OCH.sub.3).sub.3                                                                     H  H O S  A-6                                                                              OCH.sub.3                                                                           --   --                                           1,3-dioxolan-2-yl                                                                      H  H O S  A-6                                                                              CH.sub.3                                                                            --   --                                           1,3-dioxolan-2-yl                                                                      H  H O S  A-6                                                                              OCH.sub.3                                                                           --   --                                           CH(OCH.sub.3).sub.2                                                                    H  H O S  A-6                                                                              CH.sub.3                                                                            --   --                                           CH(OCH.sub.3).sub.2                                                                    H  H O S  A-6                                                                              OCH.sub.3                                                                           --   --                                           CH(OCH.sub.3).sub.2                                                                    H  H O O  A-6                                                                              CH.sub.3                                                                            --   --                                                                 X.sub.4                                                                             Y.sub.4                                           CH(OCH.sub.3).sub.2                                                                    H  H O S  A-7                                                                              CH.sub.3                                                                            CH.sub.3                                                                              CH                                        CH(OCH.sub.3).sub.2                                                                    H  H O S  A-7                                                                              OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                        1,3-dioxolan-2-yl                                                                      H  H O S  A-7                                                                              CH.sub.3                                                                            CH.sub.3                                                                              CH                                        1,3-dioxolan-2-yl                                                                      H  H O S  A-7                                                                              OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                        C(OCH.sub.3).sub.3                                                                     H  H O S  A-7                                                                              CH.sub.3                                                                            CH.sub.3                                                                              CH                                        C(OCH.sub.3).sub.3                                                                     H  H O S  A-7                                                                              CH.sub.3                                                                            CH.sub.3                                                                              N                                         C(OCH.sub.3).sub.3                                                                     H  H O S  A-7                                                                              OCH.sub.3                                                                           CH.sub.3                                                                              CH                                        C(OCH.sub.3).sub. 3                                                                    H  H O S  A-7                                                                              OCH.sub.3                                                                           CH.sub.3                                                                              N                                         C(OCH.sub.3).sub.3                                                                     H  H O S  A-7                                                                              OCH.sub.3                                                                           OCH.sub.3                                                                             N                                         C(OCH.sub.3).sub.3                                                                     H  H O S  A-7                                                                              Cl    CH.sub.3                                                                              CH                                        C(OCH.sub.3).sub.3                                                                     H  H O S  A-7                                                                              OCH.sub.3                                                                           Cl      CH                                        C(OCH.sub.3).sub.3                                                                     H  H O S  A-7                                                                              OC.sub.2 H.sub.5                                                                    CH.sub.3                                                                              CH                                        C(OCH.sub.3).sub.3                                                                     H  H O S  A-7                                                                              CH.sub.2 OCH.sub.3                                                                  CH.sub.3                                                                              N                                         C(OCH.sub.3).sub.3                                                                     H  H O S  A-7                                                                              CH.sub.2 OCH.sub.3                                                                  OCH.sub.3                                                                             CH                                        C(OCH.sub.3).sub.3                                                                     H  H O S  A-7                                                                              OC.sub.2 H.sub.5                                                                    OC.sub.2 H.sub.5                                                                      N                                         C(OCH.sub.3).sub.3                                                                     H  H O O  A-7                                                                              CH.sub.3                                                                            CH.sub.3                                                                              CH                                        __________________________________________________________________________

                                      TABLE IVb                                   __________________________________________________________________________    General Structure IVb                                                         R.sub.1  R.sub.12                                                                        R W W.sub.1                                                                         A                m .p. °C.                            __________________________________________________________________________                        X.sub.1                                                                             Y.sub.1                                                                            Y.sub.2                                        1,3-dioxolan-2-yl                                                                      H H O S A-2                                                                              CH.sub.3                                                                            O    --                                             1,3-dioxolan-2-yl                                                                      H H O S A-2                                                                              OCH.sub.3                                                                           O    --                                             1,3-dioxolan-2-yl                                                                      H H O S A-2                                                                              OCF.sub.2 H                                                                         O    --                                             1,3-dioxolan-2-yl                                                                      H H O S A-2                                                                              CH.sub.3                                                                            CH.sub.2                                                                           --                                             1,3-dioxolan-2-yl                                                                      H H O S A-2                                                                              OCH.sub.3                                                                           CH.sub.2                                                                           --                                             1,3-dioxolan-2-yl                                                                      H H O S A-2                                                                              OC.sub.2 H.sub.5                                                                    CH.sub.2                                                                           --                                             1,3-dioxolan-2-yl                                                                      H H O O A-2                                                                              CH.sub.3                                                                            O    --                                             1,3-dioxolan-2-yl                                                                      H H O O A-2                                                                              OCH.sub.3                                                                           O    --                                             1,3-dioxolan-2-yl                                                                      H H O O A-2                                                                              OCH.sub.3                                                                           CH.sub.2                                                                           --                                             1,3-dithiolan-2-yl                                                                     H H O S A-2                                                                              CH.sub.3                                                                            O    --                                             1,3-dithiolan-2-yl                                                                     H H O S A-2                                                                              OCH.sub.3                                                                           CH   --                                             1,3-dithiolan-2-yl                                                                     H H O O A-2                                                                              CH.sub.3                                                                            O    --                                             1,3-dithiolan-2-yl                                                                     H H O O A-2                                                                              OCH.sub.3                                                                           CH   --                                             CH(OCH.sub.3).sub.2                                                                    H H O S A-2                                                                              CH.sub.3                                                                            O    --                                             CH(OCH.sub.3).sub.2                                                                    H H O O A-2                                                                              CH.sub.3                                                                            O    --                                             1,3-dioxolan-2-yl                                                                      H H O S A-3                                                                              CH.sub.3                                                                            --   --                                             1,3-dioxolan-2-yl                                                                      H H O S A-3                                                                              OCH.sub.3                                                                           --   --                                             1,3-dioxolan-2-yl                                                                      H H O O A-3                                                                              OCF.sub.2 H                                                                         --   --                                             1,3-dioxolan-2-yl                                                                      H H O S A-4                                                                              OCH.sub.3                                                                           --   CH.sub.3                                       1,3-dioxolan 2-yl                                                                      H H O S A-4                                                                              CH.sub.3                                                                            --   CH.sub.3                                       1,3-dioxolan-2-yl                                                                      H H O S A-4                                                                              OC.sub.2 H.sub.5                                                                    --   H                                              1,3-dioxolan-2-yl                                                                      H H O O A-4                                                                              CH.sub.3                                                                            --   CH.sub.3                                       1,3-dioxolan-2-yl                                                                      H H O O A-4                                                                              OCF.sub.2 H                                                                         --   CH.sub.3                                       1,3-dithiolan-2-yl                                                                     H H O S A-3                                                                              CH.sub.3                                                                            --   --                                             1,3-dithiolan-2-yl                                                                     H H O S A-4                                                                              CH.sub.3                                                                            --   CH.sub.3                                       CH(OCH.sub.3).sub.2                                                                    H H O S A-3                                                                              OCH.sub.3                                                                           --   --                                             CH(OCH.sub.3).sub.2                                                                    H H O S A-4                                                                              OCH.sub.3                                                                           --   CH.sub.3                                       C(OCH.sub.3).sub.3                                                                     H H O S A-2                                                                              CH.sub.3                                                                            O    --                                             C(OCH.sub. 3).sub.3                                                                    H H O S A-2                                                                              OCH.sub.3                                                                           O    --                                             C(OCH.sub.3).sub.3                                                                     H H O S A-2                                                                              OCF.sub.2 H                                                                         O    --                                             C(OCH.sub.3).sub.3                                                                     H H O S A-2                                                                              CH.sub.3                                                                            CH.sub.2                                                                           --                                             C(OCH.sub.3).sub.3                                                                     H H O S A-2                                                                              OCH.sub.3                                                                           CH.sub.2                                                                           --                                             C(OCH.sub.3).sub.3                                                                     H H O S A-2                                                                              OC.sub.2 H.sub.5                                                                    CH.sub.2                                                                           --                                             C(OCH.sub.3).sub.3                                                                     H H O O A-3                                                                              CH.sub.3                                                                            --   --                                             C(OCH.sub.3).sub.3                                                                     H H O O A-3                                                                              OCH.sub.3                                                                           --   --                                             C(OCH.sub.3).sub.3                                                                     H H O O A-3                                                                              OCF.sub.2 H                                                                         --   --                                             C(OCH.sub.3).sub.3                                                                     H H O O A-4                                                                              OCH.sub.3                                                                           --   CH.sub.3                                       C(OCH.sub.3).sub.3                                                                     H H O O A-4                                                                              CH.sub.3                                                                            --   CH.sub.3                                       C(OCH.sub.3).sub.3                                                                     H H O O A-4                                                                              OC.sub.2 H.sub.5                                                                    --   H                                              C(OCH.sub.3).sub.3                                                                     H H O O A-4                                                                              OCF.sub.2 H                                                                         --   CH.sub.3                                       C(OCH.sub.3).sub.3                                                                     H H O O A-2                                                                              CH.sub.3                                                                            O    --                                             C(OC.sub.2 H.sub. 5).sub.3                                                             H H O O A-2                                                                              CH.sub.3                                                                            O    --                                             C(OC.sub.2 H.sub.5).sub.3                                                              H H O S A-2                                                                              CH.sub.3                                                                            O    --                                                                 X.sub.2                                                                             Y.sub.3                                             C(OCH.sub.3).sub.3                                                                     H H O S A-5                                                                              CH.sub.3                                                                            OCH.sub.3                                           C(OCH.sub.3).sub.3                                                                     H H O S A-5                                                                              CH.sub.3                                                                            OC.sub.2 H.sub.5                                    C(OCH.sub.3).sub.3                                                                     H H O S A-5                                                                              CH.sub.3                                                                            SCH.sub.3                                           C(OCH.sub.3).sub.3                                                                     H H O S A-5                                                                              CH.sub.3                                                                            SC.sub.2 H.sub.5                                    C(OCH.sub.3).sub.3                                                                     H H O S A-5                                                                              CH.sub.3                                                                            CH.sub.3                                            C(OCH.sub.3).sub.3                                                                     H H O S A-5                                                                              CH.sub.3                                                                            C.sub.2 H.sub.5                                     C(OCH.sub.3).sub.3                                                                     H H O S A-5                                                                              CH.sub.3                                                                            OCF.sub.2 H                                         C(OCH.sub.3).sub.3                                                                     H H O S A-5                                                                              CH.sub.3                                                                            SCF.sub.2 H                                         C(OCH.sub.3).sub.3                                                                     H H O S A-5                                                                              C.sub.2 H.sub.5                                                                     OCH.sub.3                                           C(OCH.sub.3).sub.3                                                                     H H O S A-5                                                                              CH.sub.2 CF.sub.3                                                                   OCH.sub.3                                           C(OCH.sub.3).sub.3                                                                     H H O O A-5                                                                              CH.sub.3                                                                            OCH.sub.3                                           1,3-dioxolan-2-yl                                                                      H H O S A-5                                                                              CH.sub.3                                                                            OCH.sub.3                                                                          --                                             1,3-dioxolan-2-yl                                                                      H H O S A-5                                                                              CH.sub.3                                                                            OC.sub.2 H.sub.5                                                                   --                                             1,3-dioxolan-2-yl                                                                      H H O S A-5                                                                              CH.sub.3                                                                            SCH.sub.3                                                                          --                                             1,3-dioxolan-2-yl                                                                      H H O S A-5                                                                              CH.sub.3                                                                            SC.sub.2 H.sub.5                                                                   --                                             1,3-dioxolan-2-yl                                                                      H H O S A-5                                                                              CH.sub.3                                                                            OCF.sub.2 H                                                                        --                                             1,3-dioxolan-2-yl                                                                      H H O S A-5                                                                              CH.sub.3                                                                            SCF.sub.2 H                                                                        --                                             CH(OCH.sub.3).sub.2                                                                    H H O S A-5                                                                              CH.sub.3                                                                            OCH.sub.3                                                                          --                                             CH(OCH.sub.3).sub.2                                                                    H H O S A-5                                                                              CH.sub.3                                                                            OC.sub.2 H.sub.5                                                                   --                                             CH(OCH.sub.3).sub.2                                                                    H H O S A-5                                                                              CH.sub.3                                                                            SCH.sub.3                                                                          --                                             CH(OCH.sub.3).sub.2                                                                    H H O S A-5                                                                              CH.sub.3                                                                            SC.sub.2 H.sub.5                                                                   --                                             CH(OCH.sub.3).sub.2                                                                    H H O S A-5                                                                              CH.sub.3                                                                            OCF.sub.2 H                                                                        --                                             CH(OCH.sub.3).sub.2                                                                    H H O S A-5                                                                              CH.sub.3                                                                            SCF.sub.2 H                                                                        --                                             CH(OCH.sub.3).sub.2                                                                    H H O O A-5                                                                              CH.sub.3                                                                            OCH.sub.3                                                                          --                                                                 X.sub.3                                                   C(OCH.sub.3).sub.3                                                                     H H O S A-6                                                                              CH.sub.3                                                                            --   --                                             C(OCH.sub.3).sub.3                                                                     H H O S A-6                                                                              OCH.sub.3                                                                           --   --                                             1,3-dioxolan-2-yl                                                                      H H O S A-6                                                                              CH.sub.3                                                                            --   --                                             1,3-dioxolan-2-yl                                                                      H H O S A-6                                                                              OCH.sub.3                                                                           --   --                                             CH(OCH.sub.3).sub.2                                                                    H H O S A-6                                                                              CH.sub.3                                                                            --   --                                             CH(OCH.sub.3).sub.2                                                                    H H O S A-6                                                                              OCH.sub.3                                                                           --   --                                             CH(OCH.sub.3).sub.2                                                                    H H O O A-6                                                                              CH.sub.3                                                                            --   --                                                                 X.sub.4                                                                             Y.sub.4                                                                            Z                                              CH(OCH.sub.3).sub.2                                                                    H H O S A-7                                                                              CH.sub.3                                                                            CH.sub.3                                                                           CH                                             CH(OCH.sub.3).sub.2                                                                    H H O S A-7                                                                              OCH.sub.3                                                                           OCH.sub.3                                                                          CH                                             1,3-dioxolan-2-yl                                                                      H H O S A-7                                                                              CH.sub.3                                                                            CH.sub.3                                                                           CH                                             1,3-dioxolan-2-yl                                                                      H H O S A-7                                                                              OCH.sub.3                                                                           OCH.sub.3                                                                          CH                                             C(OCH.sub.3).sub.3                                                                     H H O S A-7                                                                              CH.sub.3                                                                            CH.sub.3                                                                           CH                                             C(OCH.sub.3).sub.3                                                                     H H O S A-7                                                                              CH.sub.3                                                                            CH.sub.3                                                                           N                                              C(OCH.sub.3).sub.3                                                                     H H O S A-7                                                                              OCH.sub.3                                                                           CH.sub.3                                                                           CH                                             C(OCH.sub.3 ).sub.3                                                                    H H O s A-7                                                                              OCH.sub.3                                                                           CH.sub.3                                                                           N                                              C(OCH.sub.3).sub.3                                                                     H H O S A-7                                                                              OCH.sub.3                                                                           OCH.sub.3                                                                          N                                              C(OCH.sub.3).sub.3                                                                     H H O S A-7                                                                              Cl    CH.sub.3                                                                           CH                                             C(OCH.sub.3).sub.3                                                                     H H O S A-7                                                                              OCH.sub.3                                                                           Cl   CH                                             C(OCH.sub.3).sub.3                                                                     H H O S A-7                                                                              OC.sub.2 H.sub.5                                                                    CH.sub.3                                                                           CH                                             C(OCH.sub.3).sub.3                                                                     H H O S A-7                                                                              CH.sub.2 OCH.sub.3                                                                  CH.sub.3                                                                           N                                              C(OCH.sub.3).sub.3                                                                     H H O S A-7                                                                              CH.sub.2 OCH.sub.3                                                                  OCH.sub.3                                                                          CH                                             C(OCH.sub.3).sub.3                                                                     H H O S A-7                                                                              OC.sub.2 H.sub.5                                                                    OC.sub.2 H.sub.5                                                                   N                                              C(OCH.sub.3).sub.3                                                                     H H O O A-7                                                                              CH.sub.3                                                                            CH.sub.3                                                                           CH                                             __________________________________________________________________________

                                      TABLE V                                     __________________________________________________________________________    General Structure V                                                           R.sub.1  R.sub.11                                                                         R.sub.12                                                                         R W A  A.sub.1 Y.sub.1                                                                              Y   Z  m.p. °C.                   __________________________________________________________________________                             X.sub.1 Y.sub.2                                      1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                            H O A-2   CH.sub.3                                                                           O  --                                           1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                            H O A-2   OCF.sub.2 H                                                                        O  --                                           1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                            H O A-2   OCH.sub.3                                                                          O  --                                           1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                            H O A-2   CH.sub.3                                                                           CH.sub.2                                                                         --                                           1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                            H O A-2   OCH.sub.3                                                                          CH.sub.2                                                                         --                                           1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                            H O A-2   OC.sub.2 H.sub.5                                                                   CH.sub.2                                                                         --                                           1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                            H O A-2   CH.sub.3                                                                           O  --                                           1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                            H O A-2   OCH.sub.3                                                                          CH.sub.2                                                                         --                                           1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                            H O A-3   CH.sub.3                                                                           -- --                                           1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                            H O A-3   OCH.sub. 3                                                                         -- --                                           1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                            H O A-4   CH.sub.3                                                                           -- CH.sub.3                                     1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                            H O A-4   OCH.sub.3                                                                          -- H                                            1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                            H O A-4   OCF.sub.2 H                                                                        -- CH.sub.3                                     C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H  H O    A-2                                                                              CH.sub.3                                                                              O   --                                       C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H  H O    A-3                                                                              CH.sub.3                                                                              --  --                                       C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H  H O    A-4                                                                              CH.sub.3                                                                              --  CH.sub.3                                                          X.sub.2                                              C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H  H O    A-5                                                                              CH.sub.3                                                                              --  OCH.sub.3                                1,3-dioxolan-                                                                          CH.sub.3                                                                         H  H O    A-5                                                                              CH.sub.3                                                                              SCH.sub.3                                                                         --                                       2-yl                                                                                                   X.sub.3                                              C(CH.sub.3)(OCH.sub.3).sub.2                                                           CH.sub.3                                                                         H  H O    A-6                                                                              CH.sub.3                                                                              --  --                                       C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H  H O    A-6                                                                              OCH.sub.3                                                                             --  --                                                                X.sub. 4                                                                              Y.sub.4                                      1,3-dioxolan-                                                                          CH.sub.3                                                                         H  H O    A-7                                                                              CH.sub.3                                                                              CH.sub.3                                                                              CH                                   2-yl                                                                          C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H  H O    A-7                                                                              OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                   __________________________________________________________________________

                                      TABLE Va                                    __________________________________________________________________________    General Structure Va                                                          R.sub.1  R.sub.11                                                                         R W A           Y.sub.2                                                                          Z  m.p. °C.                             __________________________________________________________________________                       X.sub.1                                                                            Y.sub.1                                               1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-2                                                                              CH.sub.3                                                                           O   --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-2                                                                              OCF.sub.2 H                                                                        O   --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-2                                                                              OCH.sub.3                                                                          O   --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-2                                                                              CH.sub.3                                                                           CH.sub.2                                                                          --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-2                                                                              OCH.sub.3                                                                          CH.sub.2                                                                          --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-2                                                                              OC.sub.2 H.sub.5                                                                   CH.sub.2                                                                          --                                                1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                         H O A-2                                                                              CH.sub.3                                                                           O   --                                                1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                         H O A-2                                                                              OCH.sub.3                                                                          CH.sub.2                                                                          --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-3                                                                              CH.sub.3                                                                           --  --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-3                                                                              OCH.sub.3                                                                          --  --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-4                                                                              CH.sub.3                                                                           --  CH.sub.3                                          1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-4                                                                              OCH.sub.3                                                                          --  H                                                 1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-4                                                                              OCF.sub.2 H                                                                        --  CH.sub.3                                          C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H O A-2                                                                              CH.sub.3                                                                           O   --                                                C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H O A-3                                                                              CH.sub.3                                                                           --  --                                                C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H O A-4                                                                              CH.sub.3                                                                           --  CH.sub.3                                                             X.sub.2                                                                            Y.sub.2                                               C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H O A-5                                                                              CH.sub.3                                                                           OCH.sub.3                                             1,3-dioxolan-                                                                          CH.sub.3                                                                         H O A-5                                                                              CH.sub.3                                                                           SCH.sub.3                                             2-yl                                                                                             X.sub.3                                                    C(CH.sub.3)(OCH.sub.3).sub.2                                                           CH.sub.3                                                                         H O A-6                                                                              CH.sub.3                                                   C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H O A-6                                                                              OCH.sub.3                                                                     X.sub.4                                                                            Y.sub.4                                               1,3-dioxolan-                                                                          CH.sub.3                                                                         H O A-7                                                                              CH.sub.3                                                                           CH.sub.3                                                                             CH                                             2-yl                                                                          C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H O A-7                                                                              OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                             __________________________________________________________________________

                                      TABLE Vb                                    __________________________________________________________________________    General Structure Vb                                                          R.sub.1  R.sub.11                                                                         R W A           Y.sub.2                                                                          Z  m.p. °C.                             __________________________________________________________________________                       X.sub.1                                                                            Y.sub.1                                               1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-2                                                                              CH.sub.3                                                                           O   --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-2                                                                              OCF.sub.2 H                                                                        O   --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-2                                                                              OCH.sub.3                                                                          O   --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-2                                                                              CH.sub.3                                                                           CH.sub.2                                                                          --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-2                                                                              OCH.sub.3                                                                          CH.sub.2                                                                          --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-2                                                                              OC.sub.2 H.sub.5                                                                   CH.sub.2                                                                          --                                                1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                         H O A-2                                                                              CH.sub.3                                                                           O   --                                                1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                         H O A-2                                                                              OCH.sub.3                                                                          CH.sub.2                                                                          --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-3                                                                              CH.sub.3                                                                           --  --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-3                                                                              OCH.sub.3                                                                          --  --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-4                                                                              CH.sub.3                                                                           --  CH.sub.3                                          1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-4                                                                              OCH.sub.3                                                                          --  H                                                 1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-4                                                                              OCF.sub.2 H                                                                        --  CH.sub.3                                          C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H O A-2                                                                              CH.sub.3                                                                           O   --                                                C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H O A-3                                                                              CH.sub.3                                                                           --  --                                                C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H O A-4                                                                              CH.sub.3                                                                           --  CH.sub.3                                                             X.sub.2                                                                            Y.sub.3                                               C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H O A-5                                                                              CH.sub.3                                                                           OCH.sub.3                                             1,3-dioxolan-                                                                          CH.sub.3                                                                         H O A-5                                                                              CH.sub.3                                                                           SCH.sub.3                                             2-yl                                                                                             X.sub.3                                                    C(CH.sub.3)(OCH.sub.3).sub.2                                                           CH.sub.3                                                                         H O A-6                                                                              CH.sub.3                                                                           --  --                                                C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H O A-6                                                                              OCH.sub.3                                                                          --  --                                                                   X.sub.4                                                                            Y.sub.4                                               1,3-dioxolan-                                                                          CH.sub.3                                                                         H O A-7                                                                              CH.sub.3                                                                           CH.sub.3                                                                             CH                                             2-yl                                                                          C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H O A-7                                                                              OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                             __________________________________________________________________________

                                      TABLE Vc                                    __________________________________________________________________________    General Structure Vc                                                          R.sub.1  R.sub.11                                                                         R W A           Y.sub.2                                                                          Z  m.p. °C.                             __________________________________________________________________________                       X.sub.1                                                                            Y.sub.1                                               1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-2                                                                              CH.sub.3                                                                           O   --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-2                                                                              OCF.sub.2 H                                                                        O   --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-2                                                                              OCH.sub.3                                                                          O   --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-2                                                                              CH.sub.3                                                                           CH.sub.2                                                                          --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-2                                                                              OCH.sub.3                                                                          CH.sub.2                                                                          --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-2                                                                              OC.sub.2 H.sub.5                                                                   CH.sub.2                                                                          --                                                1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                         H O A-2                                                                              CH.sub.3                                                                           O   --                                                1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                         H O A-2                                                                              OCH.sub.3                                                                          CH.sub.2                                                                          --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-3                                                                              CH.sub.3                                                                           --  --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-3                                                                              OCH.sub.3                                                                          --  --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-4                                                                              CH.sub.3                                                                           --  CH.sub.3                                          1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-4                                                                              OCH.sub.3                                                                          --  H                                                 1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-4                                                                              OCF.sub.2 H                                                                        --  CH.sub.3                                          C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H O A-2                                                                              CH.sub.3                                                                           O   --                                                C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H O A-3                                                                              CH.sub.3                                                                           --  --                                                C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H O A-4                                                                              CH.sub.3                                                                           --  CH.sub.3                                                             X.sub.2                                                                            Y.sub.3                                               C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H O A-5                                                                              CH.sub.3                                                                           OCH.sub.3                                             1,3-dioxolan-                                                                          CH.sub.3                                                                         H O A-5                                                                              CH.sub.3                                                                           SCH.sub.3                                             2-yl                                                                                             X.sub.3                                                    C(CH.sub.3)(OCH.sub.3).sub.2                                                           CH.sub.3                                                                         H O A-6                                                                              CH.sub.3                                                                           --     --                                             C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H O A-6                                                                              OCH.sub.3                                                                          --     --                                                                X.sub.4                                                                            Y.sub.4                                               1,3-dioxolan-                                                                          CH.sub.3                                                                         H O A-7                                                                              CH.sub.3                                                                           CH.sub.3                                                                             CH                                             2-yl                                                                          C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H O A-7                                                                              OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                             __________________________________________________________________________

                                      TABLE VI                                    __________________________________________________________________________    General Structure VI                                                          R.sub.1  R  W A           Y.sub.2                                                                          Z  m.p. °C.                               __________________________________________________________________________                     X.sub.1                                                                            Y.sub.1                                                 1,3-dioxolan-2-yl                                                                      H  O A-2                                                                              CH.sub.3                                                                           O   --                                                  1,3-dioxolan-2-yl                                                                      H  O A-2                                                                              OCF.sub.2 H                                                                        O   --                                                  1,3-dioxolan-2-yl                                                                      H  O A-2                                                                              OCH.sub.3                                                                          O   --                                                  1,3-dioxolan-2-yl                                                                      H  O A-2                                                                              CH.sub.3                                                                           CH.sub.2                                                                          --                                                  1,3-dioxolan-2-yl                                                                      H  O A-2                                                                              OCH.sub.3                                                                          CH.sub.2                                                                          --                                                  1,3-dioxolan-2-yl                                                                      H  O A-2                                                                              OC.sub.2 H.sub.5                                                                   CH.sub.2                                                                          --                                                  1,3-dithiolan-2-yl                                                                     H  O A-2                                                                              CH.sub.3                                                                           O   --                                                  1,3-dithiolan-2-yl                                                                     H  O A-2                                                                              OCH.sub.3                                                                          CH.sub.2                                                                          --                                                  1,3-dioxolan-2-yl                                                                      H  O A-3                                                                              CH.sub.3                                                                           --  --                                                  1,3-dioxolan-2-yl                                                                      H  O A-3                                                                              OCH.sub.3                                                                          --  --                                                  1,3-dioxolan-2-yl                                                                      H  O A-4                                                                              CH.sub.3                                                                           --  CH.sub.3                                            1,3-dioxolan-2-yl                                                                      H  O A-4                                                                              OCH.sub.3                                                                          --  H                                                   1,3-dioxolan-2-yl                                                                      H  O A-4                                                                              OCF.sub.2 H                                                                        --  CH.sub.3                                            C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         O A-2                                                                              CH   O.sub.3                                                                           --                                                  C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         O A-3                                                                              CH.sub.3                                                                           --  --                                                  C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         O A-4                                                                              CH.sub.3                                                                           --  CH.sub.3                                                             X.sub.2                                                                            Y.sub.3                                                 C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         O A-5                                                                              CH.sub.3                                                                           OCH.sub.3                                               1,3-dioxolan-                                                                          CH.sub.3                                                                         O A-5                                                                              CH.sub.3                                                                           SCH.sub.3                                               2-yl                                                                                           X.sub.3                                                      C(CH.sub.3)(OCH.sub.3).sub.2                                                           CH.sub.3                                                                         O A-6                                                                              CH.sub.3                                                                           --  --                                                  C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         O A-6                                                                              OCH  --.sub.3                                                                          --                                                                   X.sub.4                                                                            Y.sub.4                                                 1,3-dioxolan-                                                                          CH.sub.3                                                                         O A-7                                                                              CH   CH.sub.3                                                                             CH.sub.3                                         2-yl                                                                          C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         O A-7                                                                              OCH  OCH.sub.3                                                                            CH.sub.3                                         __________________________________________________________________________

                                      TABLE VIa                                   __________________________________________________________________________    General Structure VIa                                                         R.sub.1  R  W A           Y.sub.2                                                                          Z  m.p. °C.                               __________________________________________________________________________                     X.sub.1                                                                            Y.sub.1                                                 1,3-dioxolan-2-yl                                                                      H  O A-2                                                                              CH.sub.3                                                                           O   --                                                  1,3-dioxolan-2-yl                                                                      H  O A-2                                                                              OCF.sub.2 H                                                                        O   --                                                  1,3-dioxolan-2-yl                                                                      H  O A-2                                                                              OCH.sub.3                                                                          O   --                                                  1,3-dioxolan-2-yl                                                                      H  O A-2                                                                              CH.sub.3                                                                           CH.sub.2                                                                          --                                                  1,3-dioxolan-2-yl                                                                      H  O A-2                                                                              OCH.sub.3                                                                          CH.sub.2                                                                          --                                                  1,3-dioxolan-2-yl                                                                      H  O A-2                                                                              OC.sub.2 H.sub.5                                                                   CH.sub.2                                                                          --                                                  1,3-dithiolan-2-yl                                                                     H  O A-2                                                                              CH.sub.3                                                                           O   --                                                  1,3-dithiolan-2-yl                                                                     H  O A-2                                                                              OCH.sub.3                                                                          CH.sub.2                                                                          --                                                  1,3-dioxolan-2-yl                                                                      H  O A-3                                                                              CH.sub.3                                                                           --  --                                                  1,3-dioxolan-2-yl                                                                      H  O A-3                                                                              OCH.sub.3                                                                          --  --                                                  1,3-dioxolan-2-yl                                                                      H  O A-4                                                                              CH.sub.3                                                                           --  CH.sub.3                                            1,3-dioxolan-2-yl                                                                      H  O A-4                                                                              OCH.sub.3                                                                          --  H                                                   1,3-dioxolan-2-yl                                                                      H  O A-4                                                                              OCF.sub.2 H                                                                        --  CH.sub.3                                            C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         O A-2                                                                              CH.sub.3                                                                           O   --                                                  C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         O A-3                                                                              CH.sub.3                                                                           --  --                                                  C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         O A-4                                                                              CH.sub.3                                                                           --  CH.sub.3                                                             X.sub.2                                                                            Y.sub.3                                                 C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         O A-5                                                                              CH.sub.3                                                                           OCH.sub.3                                               1,3-dioxolan-                                                                          CH.sub.3                                                                         O A-5                                                                              CH.sub.3                                                                           SCH.sub.3                                               2-yl                                                                                           X.sub.3                                                      C(CH.sub.3)(OCH.sub.3).sub.2                                                           CH.sub.3                                                                         O A-6                                                                              CH.sub.3                                                                           --  --                                                  C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         O A-6                                                                              OCH.sub.3                                                                          --  --                                                                   X.sub.4                                                                            Y.sub.4                                                 1,3-dioxolan-                                                                          CH.sub.3                                                                         O A-7                                                                              CH.sub.3                                                                           CH.sub.3                                                                             CH                                               2-yl                                                                          C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         O A-7                                                                              OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                               __________________________________________________________________________

                                      TABLE VIb                                   __________________________________________________________________________    General Structure VIb                                                         R.sub.1  R  W A           Y.sub.2                                                                          Z  m.p. °C.                               __________________________________________________________________________                     X.sub.1                                                                            Y.sub.1                                                 1,3-dioxolan-2-yl                                                                      H  O A-2                                                                              CH.sub.3                                                                           O   --                                                  1,3-dioxolan-2-yl                                                                      H  O A-2                                                                              OCF.sub.2 H                                                                        O   --                                                  1,3-dioxolan-2-yl                                                                      H  O A-2                                                                              OCH.sub.3                                                                          O   --                                                  1,3-dioxolan-2-yl                                                                      H  O A-2                                                                              CH.sub.3                                                                           CH.sub.2                                                                          --                                                  1,3-dioxolan-2-yl                                                                      H  O A-2                                                                              OCH.sub.3                                                                          CH.sub.2                                                                          --                                                  1,3-dioxolan-2-yl                                                                      H  O A-2                                                                              OC.sub.2 H.sub.5                                                                   CH.sub.2                                                                          --                                                  1,3-dithiolan-2-yl                                                                     H  O A-2                                                                              CH.sub.3                                                                           O   --                                                  1,3-dithiolan-2-yl                                                                     H  O A-2                                                                              OCH.sub.3                                                                          CH.sub.2                                                                          --                                                  1,3-dioxolan-2-yl                                                                      H  O A-3                                                                              CH.sub.3                                                                           --  --                                                  1,3-dioxolan-2-yl                                                                      H  O A-3                                                                              OCH.sub.3                                                                          --  --                                                  1,3-dioxolan-2-yl                                                                      H  O A-4                                                                              CH.sub.3                                                                           --  CH.sub.3                                            1,3-dioxolan-2-yl                                                                      H  O A-4                                                                              OCH.sub.3                                                                          --  H                                                   1,3-dioxolan-2-yl                                                                      H  O A-4                                                                              OCF.sub.2 H                                                                        --  CH.sub.3                                            C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         O A-2                                                                              CH.sub.3                                                                           O   --                                                  C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         O A-3                                                                              CH.sub.3                                                                           --  --                                                  C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         O A-4                                                                              CH.sub.3                                                                           --  CH.sub.3                                                             X.sub.2                                                                            Y.sub.3                                                 C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         O A-5                                                                              CH.sub.3                                                                           OCH.sub.3                                               1,3-dioxolan-                                                                          CH.sub.3                                                                         O A-5                                                                              CH.sub.3                                                                           SCH.sub.3                                               2-yl                                                                                           X.sub.3                                                      C(CH.sub.3)(OCH.sub.3).sub.2                                                           CH.sub.3                                                                         O A-6                                                                              CH.sub.3                                                                           --  --                                                  C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         O A-6                                                                              OCH.sub.3                                                                          --  --                                                                   X.sub.4                                                                            Y.sub.4                                                 1,3-dioxolan-                                                                          CH.sub.3                                                                         O A-7                                                                              CH.sub.3                                                                           CH.sub.3                                                                             CH                                               2-yl                                                                          C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         O A-7                                                                              OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                               __________________________________________________________________________

                                      TABLE VII                                   __________________________________________________________________________    General Structure VII                                                         R.sub.1   R  R.sub.14                                                                           E  W X      Y        Z  m.p. °C.                     __________________________________________________________________________    C(OCH.sub.3).sub.3                                                                      H  H    -- O CH.sub.3                                                                             CH.sub.3 CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O Cl     OCH.sub.3                                                                              CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O Br     OCH.sub.3                                                                              CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O CH.sub.3                                                                             H        CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O OCH.sub.3                                                                            H        CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O OCH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.5                                                              CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O OCF.sub.2 H                                                                          OCH.sub.3                                                                              CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O OCH.sub.3                                                                            CH(OCH.sub.3).sub.2                                                                    CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O CH.sub.3                                                                             OC.sub.2 H.sub.5                                                                       CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O CH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                     CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                     CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O OCH.sub.3                                                                            C.sub.2 H.sub.5                                                                        CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O OC.sub.2 H.sub.5                                                                     OCH.sub.3                                                                              CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O OCF.sub.2 H                                                                          OCF.sub.2 H                                                                            CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O CH.sub.2 F                                                                           OCH.sub.3                                                                              CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O CH.sub.2 Cl                                                                          OCH.sub.3                                                                              CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O CF.sub.3                                                                             OCH.sub.3                                                                              CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O Cl     OC.sub.2 H.sub.5                                                                       CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O OCH.sub.2 CH.sub.2 F                                                                 OCH.sub.3                                                                              CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O OCH.sub.2 CF.sub.3                                                                   OCH.sub.3                                                                              CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O CH.sub.3                                                                             OCH.sub.3                                                                              N                                      C(OCH.sub.3).sub.3                                                                      H  H    -- O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                      C(OCH.sub.3).sub.3                                                                      H  H    -- O CH.sub.3                                                                             CH.sub.3 N                                      C(OCH.sub.3).sub.3                                                                      H  H    -- O OCH.sub.3                                                                            cyclo-   N                                                                    propyl                                          C(OCH.sub.3).sub.3                                                                      H  H    -- O OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                             N                                      C(OCH.sub.3).sub.3                                                                      H  H    -- O OCH.sub.2 CF.sub.3                                                                   OCH.sub.3                                                                              N                                      C(OCH.sub.3).sub.3                                                                      H  H    -- O OCH.sub.2 CH.sub.2 F                                                                 CH.sub.3 N                                      C(OCH.sub.3).sub.3                                                                      H  H    -- O OCH.sub.2 CH.sub.2 F                                                                 OCH.sub.3                                                                              N                                      C(OCH.sub.3).sub.3                                                                      H  H    -- S OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                     C(OCH.sub.3).sub.3                                                                      H  3-F  -- O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                     C(OCH.sub.3).sub.3                                                                      H  5-Cl -- O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                     C(OCH.sub.3).sub.3                                                                      H  5-CH.sub.3                                                                         -- O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                     C(OCH.sub.3).sub.3                                                                      H  5-C.sub.2 H.sub.5                                                                  -- O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                     C(OCH.sub.3).sub.3                                                                      H  6-OCH.sub.3                                                                        -- O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                     C(OCH.sub.3).sub.3                                                                      H  6-OC.sub.2 H.sub.5                                                                 -- O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                     C(OCH.sub.3).sub.3                                                                      H  6-SCH.sub.3                                                                        -- O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                     C(OCH.sub.3).sub.3                                                                      H  6-SC.sub.2 H.sub.5                                                                 -- O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                     C(OCH.sub.3).sub.3                                                                      H  5-Br -- O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                     C(OCH.sub.3).sub.3                                                                      H  H    CH.sub.2                                                                         O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                     C(OC.sub.2 H.sub.5).sub.3                                                               H  H    CH.sub.2                                                                         O CH.sub.3                                                                             CH.sub.3 CH                                     C(OC.sub.2 H.sub.5).sub.3                                                               H  H    CH.sub.2                                                                         O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                     C(OC.sub.2 H.sub.5).sub.3                                                               H  H    CH.sub.2                                                                         O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                     C(OC.sub.2 H.sub.5).sub.3                                                               H  H    CH.sub.2                                                                         O Cl     OCH.sub.3                                                                              CH                                     C(OC.sub.2 H.sub.5).sub.3                                                               H  H    CH.sub.2                                                                         O CH.sub.3                                                                             OCH.sub.3                                                                              N                                      C(OC.sub.2 H.sub.5).sub.3                                                               H  H    CH.sub.2                                                                         O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                      C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H  H    CH.sub.2                                                                         O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                     C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H  H    CH.sub.2                                                                         O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                     C(OCH.sub.2 CH.sub.2 CH.sub. 3).sub.3                                                   H  H    CH.sub.2                                                                         O CH.sub.3                                                                             CH.sub.3 CH                                     C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H  H    CH.sub.2                                                                         O Cl     OCH.sub.3                                                                              CH                                     C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H  H    CH.sub.2                                                                         O CH.sub.3                                                                             OCH.sub.3                                                                              N                                      C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H  H    CH.sub.2                                                                         O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                      C(OCH.sub.3).sub.3                                                                      CH.sub.3                                                                         H    CH.sub.2                                                                         O OCH.sub.3                                                                            OCHhd 3  CH                                     C(OCH.sub.3).sub.3                                                                      H  H    CH.sub.2                                                                         O OCH.sub.2 CHF.sub.2                                                                  CH.sub.3 N                                      C(OCH.sub.3).sub.3                                                                      H  H    CH.sub.2                                                                         O CH.sub.3                                                                              .sub.-i-C.sub.3 H.sub.7                                                               CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O OCH.sub.3                                                                            N(OCH.sub.3)CH.sub.3                                                                   N                                      C(OCH.sub.3).sub.3                                                                      H  H    -- O CH.sub.3                                                                             N(CH.sub.2).sub.3                                                                      N                                      C(OCH.sub.3).sub.3                                                                      H  H    -- O OCH.sub.3                                                                            CF.sub.3 CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O CH.sub.3                                                                             SCH.sub.3                                                                              N                                      C(OCH.sub.3).sub.3                                                                      H  H    -- O CH.sub.3                                                                             OCH.sub.2 CH═CH.sub.2                                                              N                                      C(OCH.sub.3).sub.3                                                                      H  H    -- O CH.sub.3                                                                             OCH.sub.2 CH.tbd.CH                                                                    N                                      C(OCH.sub.3).sub.3                                                                      H  H    -- O CH.sub.3                                                                             CH.sub.2 SCH.sub.3                                                                     N                                      C(OCH.sub.3).sub.3                                                                      H  H    -- O OCH.sub.3                                                                            SCF.sub.2 H                                                                            CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O OCH.sub.3                                                                            1,3-dioxolan-2-yl                                                                      CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O OCH.sub.3                                                                            4-methyl-1,3-                                                                          N                                                                    dioxolan-2-yl                                   C(OCH.sub.3).sub.3                                                                      H  H    -- O OCH.sub.3                                                                            4-ethyl-1,3-                                                                           CH                                                                   dioxolan-2-yl                                   C(OCH.sub.3).sub.3                                                                      H  H    -- O OCH.sub.3                                                                            1,3-dithiolan-2-yl                                                                     CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O OCH.sub.3                                                                            1,3-oxathiolan-2-yl                                                                    N                                      C(OCH.sub.3)(OC.sub.2 H.sub.5).sub.2                                                    H  H    -- O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                     C(OC.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                    H  H    -- O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                     2-methoxy-1,3-                                                                          H  H    -- O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                     dioxolan-2-yl                                                                 2-ethoxy-1,3-                                                                           H  H    -- O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                     dioxolan-2-yl                                                                 __________________________________________________________________________

                                      TABLE VIIa                                  __________________________________________________________________________    General Structure VIIa                                                        R.sub.1   R R.sub.14                                                                         E W A           Y.sub.2                                                                          Z  m.p. °C.                          __________________________________________________________________________                          X.sub.1                                                                            Y.sub.1                                            C(OCH.sub.3).sub.3                                                                      H H  --                                                                              O A-2                                                                              CH.sub.3                                                                           O   --                                             C(OCH.sub.3).sub.3                                                                      H H  --                                                                              O A-2                                                                              OCH.sub.3                                                                          O   --                                             C(OCH.sub.3).sub.3                                                                      H H  --                                                                              O A-2                                                                              OCH.sub.3                                                                          CH.sub.2                                                                          --                                             C(OCH.sub.3).sub.3                                                                      H H  --                                                                              O A-2                                                                              OCF.sub.2 H                                                                        O   --                                             C(OC.sub.2 H.sub.5).sub.3                                                               H H  --                                                                              O A-2                                                                              CH.sub.3                                                                           O   --                                             C(OC.sub.2 H.sub.5).sub.3                                                               H H  --                                                                              O A-2                                                                              OCH.sub.3                                                                          O   --                                             C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H H  --                                                                              O A-2                                                                              CH.sub.3                                                                           O   --                                             C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H H  --                                                                              O A-2                                                                              OCH.sub.3                                                                          O   --                                             C(OCH.sub.3).sub.3                                                                      H H  --                                                                              O A-3                                                                              CH.sub.3                                                                           --  --                                             C(OCH.sub.3).sub.3                                                                      H H  --                                                                              O A-3                                                                              OCH.sub.3                                                                          --  --                                             C(OCH.sub.3).sub.3                                                                      H H  --                                                                              O A-4                                                                              CH.sub.3                                                                           --  CH.sub.3                                       C(OCH.sub.3).sub.3                                                                      H H  --                                                                              O A-4                                                                              OCH.sub.3                                                                          --  CH.sub.3                                       C(OCH.sub.3).sub.3                                                                      H H  --                                                                              O A-4                                                                              OCH.sub.3                                                                          --  H                                                                    X.sub.2                                                                            Y.sub.3                                            C(OCH.sub.3).sub.3                                                                      H H  --                                                                              O A-5                                                                              CH.sub.3                                                                           OCH.sub.3                                          C(OCH.sub.3).sub.3                                                                      H H  --                                                                              O A-5                                                                              CH.sub.3                                                                           SCH.sub.3                                          C(OCH.sub.3).sub.3                                                                      H H  --                                                                              O A-5                                                                              CH.sub.3                                                                           CH.sub.3                                                                 X.sub.3                                                 C(OCH.sub.3).sub.3                                                                      H H  --                                                                              O A-6                                                                              CH.sub.3                                                C(OCH.sub.3).sub.3                                                                      H H  --                                                                              O A-6                                                                              OCH.sub.3                                                                     X.sub.4                                                                            Y.sub.4                                            C(OCH.sub.3).sub.3                                                                      H H  --                                                                              O A-7                                                                              CH.sub.3                                                                           CH.sub.3                                                                             CH                                          C(OCH.sub.3).sub.3                                                                      H H  --                                                                              O A-7                                                                              OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                          C(OCH.sub.3 ).sub.3                                                                     H H  --                                                                              O A-7                                                                              OCH.sub.3                                                                          OCH.sub.3                                                                            N                                           __________________________________________________________________________

Formulations

Useful formulations of the compounds of Formula I can be prepared inconventional ways. They include dusts, granules, pellets, solutions,suspensions, emulsions, wettable powders, emulsifiable concentrates andthe like. Many of these may be applied directly. Sprayable formulationscan be extended in suitable media and used at spray volumes of from afew liters to several hundred liters per hectare. High strengthcompositions are primarily used as intermediates for furtherformulation. The formulations, broadly, contain about 1% to 99% byweight of active ingredient(s) and at least one of (a) about 0.1% to 20%surfactant(s) and (b) about 5% to 99% solid or liquid diluent(s). Morespecifically, they will contain these ingredients in the followingapproximate proportions:

    ______________________________________                                                    Active  Weight Percent*                                                       Ingredient                                                                            Diluent(s) Surfactant(s)                                  ______________________________________                                        Wettable Powders                                                                            20-90      0-74      1-10                                       Oil Suspensions,                                                                             5-50     40-95      0-15                                       Emulsions, Solutions,                                                         (including Emulsifiable                                                       Concentrates)                                                                 Aqueous Suspension                                                                          10-50     40-84      1-20                                       Dusts          1-25     70-99      0-5                                        Granules and Pellets                                                                         1-95      5-99      0-15                                       High Strength 90-99      0-10      0-2                                        Compositions                                                                  ______________________________________                                         *Active ingredient plus at least one of a Surfactant or a Diluent equals      100 weight percent.                                                      

Lower or higher levels of active ingredient can, of course, be presentdepending on the intended use and the physical properties of thecompound. Higher ratios of surfactant to active ingredient are sometimesdesirable, and are achieved by incorporation into the formulation or bytank mixing.

Typical solid diluents are described in Watkins, et al., "Handbook ofInsecticide Dust Diluents and Carriers", 2nd Ed., Dorland Books,Caldwell, N.J. The more absorptive diluents are preferred for wettablepowders and the denser ones for dusts. Typical liquid diluents andsolvents are described in Marsden, "Solvents Guide," 2nd Ed.,Interscience, New York, 1950. Solubility under 0.1% is preferred forsuspension concentrates; solution concentrates are preferably stableagainst phae separation at 0° C. "McCutcheon's Detergents andEmulsifiers Annual", MC Publishing Corp., Ridgewood, N.J., as well asSisely and Wood, "Encyclopedia of Surface Active Agents", ChemicalPublishing Co., Inc. New York, 1964, list surfactants and recommendedused. All formulations can contain minor amounts of additives to reducefoaming, caking, corrosion, microbiological growth, etc. Preferably,ingredients should be approved by the U.S. Environmental ProtectionAgency for the use intended.

The methods of making such compositions are well known. Solutions areprepared by simply mixing the ingredients. Fine solid compositions aremade by blending and, usually, grinding as in a hammer or fluid energymill. Suspensions are prepared by wet milling (see, for example,Littler, U.S. Pat. No. 3,060,084). Granules and pellets may be made byspraying the active material upon preformed granular carriers or byagglomeration techniques.

In the following examples, all parts are by weight unless otherwiseindicated.

EXAMPLE 5 Wettable Powder

3-(1,3-dioxolan-2-yl)-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]-2-thiophenesulfonamide:80%

sodium alkylnaphthalenesulfonate: 2%

sodium ligninsulfonate: 2%

synthetic amorphous silica: 3%

kaolinite: 13%

The ingredients are blended, hammer-milled until all the solids areessentially under 50 microns, reblended, and packaged.

EXAMPLE 6 Wettable Powder

N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3-(1,3-dioxolan-2-yl)-2-thiophenesulfonamide:50%

sodium alkylnaphthalenesulfonate: 2%

low viscosity methyl cellulose: 2%

diatomaceous earth: 36%

The ingredients are blended, coarsely hammer-milled and then air-milledto produce particles essentially all below 10 microns in diameter. Theproduct is reblended before packaging.

EXAMPLE 7 High Strength Concentrate

3-(1,3-dioxolan-2-yl)-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]-2-thiophenesulfonamide:99%

silica aerogel: 0.5%

synthetic amorphous silica: 0.5%

The ingredients are blended and ground in a hammer-mill to produce amaterial essentially all passing a U.S.S. No. 50 screen (0.3 mmopening). The concentrate may be formulated further if necessary.

EXAMPLE 8 Wettable Powder

3-(1,3-dioxolan-2-yl)-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]-2-thiophenesulfonamide:20%

sodium alkylnaphthalenesulfonic: 4%

sodium ligninsulfonate: 4%

low viscosity methyl cellulose: 3%

attapulgite: 69%

The ingredients are thoroughly blended. After grinding in a hammer-millto produce particles essentially all below 100 microns, the material isreblended and sifted through a U.S.S. No. 50 sieve (0.3 mm opening) andpackaged.

EXAMPLE 9 Oil Suspension

N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3-(1,3-dioxolan-2-yl)-2-thiophenesulfonamide:25%

polyoxyethylene sorbitol hexaoleate: 5%

highly aliphatic hydrocarbon oil: 70%

The ingredients are ground together in a sand mill until the solidparticles have been reduced to under about 5 microns. The resultingthick suspension may be applied directly, but preferably after beingextended with oils or emulsified in water.

EXAMPLE 10 Oil Suspension

3-(1,3-dioxolan-2-yl)-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]-2-thiophenesulfonamide:35%

blend of polyalcohol carboxylic esters and oil soluble petroleumsulfonates: 6%

xylene: 59%

The ingredients are combined and ground together in a sand mill toproduce particles essentially all below 5 microns. The product can beused directly, extended with oils, or emulsified in water.

EXAMPLE 11 Aqueous Suspension

3-(1,3-dioxolan-2-yl)-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]-2-thiophenesulfonamide:40%

polyacrylic acid thickener: 0.3%

dodecylphenol polyethylene glycol ether: 0.5%

disodium phosphate: 1%

monosodium phosphate: 0.5%

polyvinyl alcohol: 1.0%

water: 56.7%

The ingredients are blended and ground together in a sand mill toproduce particles essentially all under 5 microns in size.

EXAMPLE 12 Solution

3-(1,3-dioxolan-2-yl)-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]-2-thiophenesulfonamide:30%

dimethylformamide: 70%

The ingredients are combined and stirred to produce a solution, whichcan be used for low volume applications.

EXAMPLE 13 Dust

wettable powder of Example 6: 10%

Pyrophyllite (powder): 90%

The wettable powder and the pyrophyllite diluent are thoroughly blendedand then packaged. The product is suitable for use a a dust.

EXAMPLE 14 Low Strength Granule

3-(1,3-dioxolan-2-yl)-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]-2-thiophenesulfonamide:0.1%

attapulgite granules (U.S.S. 20-40 mesh): 99.9%

The active ingredient is dissolved in the solvent and the solution issprayed upon dedusted granules in a double cone blender. After sprayingof the solution has been completed, the material is warmed to evaporatethe solvent. The material is allowed to cool and then packaged.

EXAMPLE 15 Granule

Wettable Powder of Example 6: 5%

attapulgite granules (U.S.S. 20-40 mesh: 0.84-0.42 mm): 95%

A slurry of wettable powder containing 25% solids is sprayed on thesurface of attapulgite granules in a double-cone blender. The granulesare dried and packaged.

EXAMPLE 16 Granule

N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3-(1,3-dioxolan-2-yl)-2-thiophenesulfonamide:80%

wetting agent: 1%

crude ligninsulfonate salt (containing 5-20% of the natural sugars): 10%

attapulgite clay: 9%

The ingredients are blended and milled to pass through a 100 meshscreen. This material is then added to a fluid bed granulator, the airflow is adjusted to gently fluidize the material, and a fine spray ofwater is sprayed onto the fluidized material. The fluidization andspraying are continued until granules of the desired size range aremade. The spraying is stopped, but fluidization is continued, optionallywith heat, until the water content is reduced to the desired level,generally less than 1%. The material is then discharged, screened to thedesired size range, generally 14-100 mesh (1410-149 microns), andpackaged for use.

EXAMPLE 17 Extruded Pellet

3-(1,3-dioxolan-2-yl)-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]-2-thiophenesulfonamide:25%

anhydrous sodium sulfate: 10%

crude calcium ligninsulfonate: 5%

sodium alkylnaphthalenesulfonate: 1%

calcium/magnesium bentonite: 59%

The ingredients are blended, hammer-milled and then moistened with about12% water. The mixture is extruded as cylinders about 3 mm diameterwhich are cut to produce pellets about 3 mm long. These may be useddirectly after drying, or the dried pellets may be crushed to pass aU.S.S. No. 20 sieve (0.84 mm openings). The granules held on a U.S.S.No. 40 sieve (0.42 mm openings) may be packaged for use and the finesrecycled.

Utility

Test results indicate that the compounds of the present invention areactive herbicides. They have utility for broad-spectrum pre- and/orpost-emergence weed control in areas where complete control of allvegetation is desired, such as around fuel storage tanks, ammunitiondepots, industrial storage areas, parking lots, drive-in theaters,around billboards, highway and railroad structures. Alternatively, thesubject compounds are useful to modify plant growth.

The rates of application for the compounds of the invention aredetermined by a number of factors, including their use as plant growthmodifiers or as herbicides, the crop species involved, the types ofweeds to be controlled, weather and climate, formulations selected, modeof application, amount of foliage present, etc. In general terms, thesubject compounds should be applied at levels of around 0.01 to 5.0kg/ha, the lower rates being suggested for use on lighter soils and/orthose having a low organic matter content, for plant growth modificationor for situations where only short-term persistence is required.

The compounds of the invention may be used in combination with any othercommercial herbicide: examples of which are those of the triazine,triazole, uracil, urea, amide, diphenylether, carbamate and bipyridyliumtypes.

The herbicidal properties of the subject compounds were discovered in anumber of greenhouse tests. The test procedures and results follow.

    ______________________________________                                        COMPOUNDS                                                                     ______________________________________                                         ##STR53##                                                                    Compound 1                                                                     ##STR54##                                                                    Compound 2                                                                     ##STR55##                                                                    Compound 3                                                                     ##STR56##                                                                    Compound 4                                                                     ##STR57##                                                                    Compound 5                                                                     ##STR58##                                                                    Compound 6                                                                     ##STR59##                                                                    Compound 7                                                                     ##STR60##                                                                    Compound 8                                                                     ##STR61##                                                                    Compound 9                                                                    ______________________________________                                    

Test A

Seeds of crabgrass (Digitaria sp.), barnyardgrass (Echinochloacrusgalli), wild oats (Avena fatua), sicklepod (Cassia obtusifolia),morningglory (Ipomoea spp.), cocklebur (Xanthium pensylvanicum),sorghum, corn, soybean, sugar beet, cotton, rice, wheat and purplenutsedge (Cyperus rotundus) tubers were planted and treatedpre-emergence with the test chemicals dissolved in a non-phytotoxicsolvent. At the same time, these crop and weed species were treated witha soil/foliage application. At the time of treatment, the plants rangedin height from 2 to 18 cm. Treated plants and controls were maintainedin a greenhouse for sixteen days, after which all species were comparedto controls and visually rated for response to treatment. The ratings,summarized in Table A, are based on a numerical scale extending from0=no injury, to 10=complete kill. The accompanying descriptive symbolshave the following meanings:

C=chlorosis or necrosis;

B=burn

D=defoliation

E=emergence inhibition;

G=growth retardation; and

H=formative effects.

U=unusual pigmentation

X=axillary stimulation

S=albinism

6Y=abscised buds or flowers.

                                      TABLE A                                     __________________________________________________________________________            Compound 1                                                                           Compound 2                                                                           Compound 3                                                                           Compound 4                                                                           Compound 5                                Rate kg/ha                                                                            0.05   0.05   0.05   0.05   0.05                                      __________________________________________________________________________    POST-EMERGENCE                                                                Morningglory                                                                          9C     10C    10C    10C    10C                                       Cocklebur                                                                             9C     10C    4C,9H  9C     9H                                        Sicklepod                                                                             2C,5G  7G                                                             Nutsedge                                                                              4G     10C    9C     8C     4G                                        Crabgrass                                                                             3C,8G  5C,9G  7H     7G     2G                                        Barnyardgrass                                                                         5C,9H  9C     9C     9C     9C                                        Wild Oats                                                                             8G     5C,9G  2C,5G  2G     0                                         Wheat   5G     6C,9G  2G     2G     0                                         Corn    2C,9G  3C,9G  7U,9C  10C    7U,9C                                     Soybean 9C     9C     9C     9C     5C,9G                                     Rice    9C     9C     9C     9C     4C,8G                                     Sorghum 9G     5C,9G  5C,9H  2U,8H  3C,9H                                     Sugar beet                                                                            10C    9C     9C     9C     9C                                        Cotton  9C     9C     9C     9C     5C,9G                                     Velvet leaf           9C     9C     2C,7G                                     Cheatgrass            10C    6C,9G  0                                         PRE-EMERGENCE                                                                 Morningglory                                                                          9G     4C,9G  9C     9G     9G                                        Cocklebur                                                                             8H     9H     7H     8H     3H                                        Sicklepod                                                                             9G     9G                                                             Nutsedge                                                                              0      10E    10E    10E    3G                                        Crabgrass                                                                             2C,5G  7G     2C,7G  4C,9G  2G                                        Barnyardgrass                                                                         3C,7H  9H     9H     9H     3C,7G                                     Wild Oats                                                                             6C,9G  5C,9G  8G     8G     3G                                        Wheat   5G     4C,9G  2C,8H  8G     2G                                        Corn    5C,9H  9G     9H     4C,9H  2C,9G                                     Soybean 9H     9H     8H     9H     2C,5G                                     Rice    10E    10E    10E    10E    3C,8H                                     Sorghum 5C,9H  6C,9H  9H     3C,9H  3C,9H                                     Sugar beet                                                                            5C,9G  9C     5C,9G  5C,9G  5C,9G                                     Cotton  2C,9G  9G     9G     9G     2C,8G                                     Velvet leaf           10C    9C     5G                                        Cheatgrass            4C,9H  3C,9H  6G                                        __________________________________________________________________________                   Compound 6                                                                           Compound 7                                                                           Compound 8                                                                           Compound 9                                       Rate kg/ha                                                                            0.05   0.05   0.05   0.05                                      __________________________________________________________________________           POST-EMERGENCE                                                                Morningglory                                                                          10C    6C,9G  9C     10C                                              Cocklebur                                                                             9C     9C     10C    9C                                               Sicklepod                                                                     Nutsedge                                                                              9C     6G     3G     4C,8G                                            Crabgrass                                                                             2C,6G  5G     4G     0                                                Barnyardgrass                                                                         3C,9H  4C,9H  4C,9H  8H                                               Wild Oats                                                                             0      0      0      0                                                Wheat   0      0      0      0                                                Corn    2C,8H  2C,9G  5C,9G  1H                                               Soybean 5C,9G  5C,9G  5C,9G  3H,9G,7X                                         Rice    4C,9G  7G     5G     6G                                               Sorghum 4C,9H  3C,9H  5C,9H  9H                                               Sugar beet                                                                            9C     3C,9G  9C     9C                                               Cotton  9C     9C     9C     9C                                               Velvet leaf                                                                           9C     6C,9G  10C    9C                                               Cheatgrass                                                                            3C,8G  0      2C,3H  0                                                PRE-EMERGENCE                                                                 Morningglory                                                                          9H     8H     8G     8G                                               Cocklebur                                                                             8H     9H     5G     7G                                               Sicklepod                                                                     Nutsedge                                                                              2C,9G  0      3G     3G                                               Crabgrass                                                                             0      0      0      0                                                Barnyardgrass                                                                         4C,9H  0      3C,7H  4G                                               Wild Oats                                                                             5G     0      0      0                                                Wheat   4G     0      0      0                                                Corn    8G     2C,8H  3C,9H  4G                                               Soybean 9H     3C,8H  3C,8H  5H                                               Rice    4C,9H  3C,5H  3C,7G  0                                                Sorghum 4C,8H  3C,9H  5C,9H  2C,7G                                            Sugar beet                                                                            9C     5C,9G  5C,9G  7G                                               Cotton  9G     3C,8G  8G     8G                                               Velvet leaf                                                                           9G     4C,8G  3C,8G  4G                                               Cheatgrass                                                                            3C,8G  3G     0      0                                         __________________________________________________________________________

What is claimed is:
 1. A compound of the formula ##STR62## wherein##STR63## R is H or CH₃ ; R₁ is ##STR64## E is CH₂ or a single bond; R₂is H, C₁ -C₂ alkyl or Cl;R₃ is H, C₁ -C₃ alkyl or C₁ -C₃ alkoxy; R₄ andR₅ are independently C₁ -C₂ alkyl; R₆ and R₇ are independently H or C₁-C₂ alkyl; W is O or S; W₁ is O or S; Q₁ and Q₂ are independently O, Sor NCH₃ ; A is ##STR65## X is H, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄haloalkoxy, C₁ -C₄ haloalkyl, C₁ -C₄ haloalkylthio, C₁ -C₄ alkylthio,halogen, C₂ -C₅ alkoxyalkoxy, amino, C₁ -C₃ alkylamino or di(C₁-C₃)alkylamino; Y is H, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄ haloalkoxy,C₁ -C₄ haloalkylthio, C₁ -C₄ alkylthio, halogen, C₂ -C₅ alkoxyalkyl, C₂-C₅ alkoxyalkoxy, amino, C₁ -C₃ alkylamino, di(C₁ -C₃)alkylamino, C₃ -C₄alkenyloxy, C₃ -C₄ alkynyloxy, C₂ -C₅ alkylsulfinylalkyl, C₁ -C₄haloalkyl, C₂ -C₅ alkylsulfonylalkyl, C₃ -C₅ cycloalkyl, C₂ -C₄ alkynyl,C₂ -C₅ alkylthioalkyl, C(O)R₈, ##STR66## N(OCH₃)CH₃ ; m is 2 or 3; L₁and L₂ are independently O or S; R₈ is H or CH₃ ; R₉ and R₁₀ areindependently C₁ -C₂ alkyl; R₁₁ is C₁ -C₃ alkyl; R₁₂ is H, F, Cl, NO₂,C₁ -C₂ alkyl, C₁ -C₂ alkoxy, C₁ -C₂ alkylthio, C₁ -C₂ alkylsulfinyl, C₁-C₂ alkylsulfonyl, di(C₁ -C₂)alkylsulfamoyl or CO₂ (C₁ -C₂ alkyl); R₁₃is H, C₁ -C₂ alkyl, C₁ -C₂ alkoxy, Cl, F or NO₂ ; R₁₄ is H, C₁ -C₃alkyl, C₁ -C₃ alkoxy, C₁ -C₃ haloalkyl, C₁ -C₃ haloalkoxy, Cl, Br, F,NO₂, di(C₁ -C₃)alkylsulfamoyl, C₁ -C₃ alkylthio, C₁ -C₃ alkylsulfinyl,C₁ -C₃ alkylsulfonyl, amino, C₁ -C₃ alkylamino, di(C₁ -C₃)alkylamino,CH₂ OCH₃, CH₂ SCH₃ or CH₂ CN Z is CH;and their agriculturally suitablesalts; provided that (a) when X is Cl, F, Br or I, then Y is OCH₃, OC₂H₅, N(OCH₃)CH₃, NHCH₃, N(CH₃)₂ or OCF₂ H; (b) when Y is cyclopropyl, Xis other than Cl, F, Br or I; (c) when R₃ is C₁ -C₃ alkoxy, then Q₁ andQ₂ are oxygen; (d) when R₃ is H or C₁ -C₃ alkyl, then Q is Q-1 throughQ-9; (e) when the total number of carbon atoms of X and Y is greaterthan four, then the combined number of carbons of the substituents on Qis less than or equal to ten; (f) when W is S, then A is A-1, R is H,and Y is CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃, C₂ H₅, CF₃, SCH₃, OCH₂ CH═CH₂,OCH₂ C.tbd.CH, OCH₂ CH₂ OCH₃, CH(OCH₃)₂ or ##STR67## (g) when E is CH₂,then R₁₄ is H, CH₃, OCH₃, Cl or NO₂ and is not in the 4-position.
 2. Acompound of claim 1 where R₃ is H or C₁ -C₃ alkyl.
 3. A compound ofclaim 1 where R₃ is C₁ -C₃ alkoxy.
 4. A compound of claim 2 where W isO; R is H; X is CH₃, OCH₃, OC₂ H₅, Cl, F, Br, I, OCF₂ H, CH₂ F, OCH₂ CH₂F, OCH₂ CHF₂, OCH₂ CF₃ or CF₃ ; and Y is H, C₁ -C₃ alkyl, OCH₃, OC₂ H₅,CH₂ OCH₃, NHCH₃, N(OCH₃)CH₃, N(CH₃)₂, CF₃, SCH₃, OCH₂ CH═CH₂, OCH₂C.tbd.CH, OCH₂ CH₂ OCH₃, CH₂ SCH₃, CH₂ OC₂ H₅, ##STR68## OCF₂ H, SCF₂ H,cyclopropyl, C.tbd.CH or C.tbd.CCH₃.
 5. A compound of claim 4 wherein Q₁and Q₂ are identical and are O or S, R₁₂ is H, C₁ -C₂ alkyl or Cl andR₁₃ is H.
 6. A compound of claim 5 where A is A-1; Y is CH₃, OCH₃, OC₂H₅, CH₂ OCH₃, C₂ H₅, NHCH₃, CH₂ OC₂ H₅, OCF₂ H, OCH₂ CH₂ OCH₃,cyclopropyl, C.tbd.CH or CH(OCH₃)₂ ; and X is CH₃, OCH₃, Cl, OC₂ H₅,OCF₂ H or OCH₂ CF₃.
 7. A compound of claim 6 where Q₁ and Q₂ are O.
 8. Acompound of claim 6 where Q₁ and Q₂ are S.
 9. A compound of claim 6where Q is Q-1.
 10. A compound of claim 6 where Q is Q-2.
 11. A compoundof claim 6 where Q is Q-3.
 12. A compound of claim 6 where Q is Q-4. 13.A compound of claim 6 where Q is Q-5.
 14. A compound of claim 6 where Qis Q-6.
 15. A compound of claim 6 where Q is Q-7.
 16. A compound ofclaim 6 where Q is Q-8.
 17. A compound of claim 6 where Q is Q-9.
 18. Acompound of claim 3 where W is O; R is H; X is CH₃, OCH₃, OC₂ H₅, Cl, F,Br, I, OCF₂ H, CH₂ F, OCH₂ CH₂ F, OCH₂ CHF₂, OCH₂ CF₃ or CF₃ ; and Y isH, C₁ -C₃ alkyl, OCH₃, OC₂ H₅, CH₂ OCH₃, NHCH₃, N(OCH₃)CH₃, N(CH₃)₂,CF₃, SCH₃, OCH₂ CH═CH₂, OCH₂ C.tbd.CH, OCH₂ CH₂ OCH₃, CH₂ SCH₃, CH₂ OC₂H₅, ##STR69## OCF₂ H, SCF₂ H, cyclopropyl, C.tbd.CH or C.tbd.CCH₃.
 19. Acompound of claim 18 where E is a single bond; R₁₂ is H, C₁ -C₂ alkyl orCl; R₁₃ is H; and R₁₄ is H, F, Cl, Br, C₁ -C₂ alkyl, C₁ C₂ alkoxy or C₁-C₂ alkylthio and is not para to the sulfonylurea bridge.
 20. A compoundof claim 19 where A is A-1; Y is CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃, C₂ H₅,NHCH₃, CH₂ OC₂ H₅, OCF₂ H, OCH₂ CH₂ OCH₃, cyclopropyl, C.tbd.CH orCH(OCH₃)₂ ; and X is CH₃, OCH₃, Cl, OC₂ H₅, OCF₂ H or OCH₂ CF₃.
 21. Acompound of claim 20 where Q is Q-1.
 22. A compound of claim 20 where Qis Q-2.
 23. A compound of claim 20 where Q is Q-3.
 24. A compound ofclaim 20 where Q is Q-4.
 25. A compound of claim 20 where Q is Q-5. 26.A compound of claim 20 where Q is Q-6.
 27. A compound of claim 20 whereQ is Q-7.
 28. A compound of claim 20 where Q is Q-8.
 29. A compound ofclaim 20 where Q is Q-9.
 30. A compound of claim 20 where Q is Q-10. 31.A compound of claim 1 which isN-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3-(1,3-dioxolan-2-yl)-2-thiophenesulfonamide.32. A composition suitable for controlling the growth of undesiredvegetation which comprises an effective amount of a compound of claim 1and at least one of the following: surfactant, solid or liquid inertdiluent.
 33. A composition suitable for controlling the growth ofundesired vegetation which comprises an effective amount of a compoundof claim 2 and at least one of the following: surfactant, solid orliquid inert diluent.
 34. A composition suitable for controlling thegrowth of undesired vegetation which comprises an effective amount of acompound of claim 3 and at least one of the following: surfactant, solidor liquid inert diluent.
 35. A composition suitable for controlling thegrowth of undesired vegetation which comprises an effective amount of acompound of claim 4 and at least one of the following: surfactant, solidor liquid inert diluent.
 36. A composition suitable for controlling thegrowth of undesired vegetation which comprises an effective amount of acompound of claim 5 and at least one of the following: surfactant, solidor liquid inert diluent.
 37. A composition suitable for controlling thegrowth of undesired vegetation which comprises an effective amount of acompound of claim 6 and at least one of the following: surfactant, solidor liquid inert diluent.
 38. A composition suitable for controlling thegrowth of undesired vegetation which comprises an effective amount of acompound of claim 18 and at least one of the following: surfactant,solid or liquid inert diluent.
 39. A composition suitable forcontrolling the growth of undesired vegetation which comprises aneffective amount of a compound of claim 19 and at least one of thefollowing: surfactant, solid or liquid inert diluent.
 40. A compositionsuitable for controlling the growth of undesired vegetation whichcomprises an effective amount of a compound of claim 20 and at least oneof the following: surfactant, solid or liquid inert dluent.
 41. A methodfor controlling the growth of undesired vegetation which comprisesapplying to the locus to be protected an effective amount of a compoundof claim
 1. 42. A method for controlling the growth of undesiredvegetation which comprises applying to the locus to be protected aneffective amount of a compound of claim
 2. 43. A method for controllingthe growth of undesired vegetation which comprises applying to the locusto be protected an effective amount of a compound of claim
 3. 44. Amethod for controlling the growth of undesired vegetation whichcomprises applying to the locus to be protected an effective amount of acompound of claim
 4. 45. A method for controlling the growth ofundesired vegetation which comprises applying to the locus to beprotected an effective amount of a compound of claim
 5. 46. A method forcontrolling the growth of undesired vegetation which comprises applyingto the locus to be protected an effective amount of a compound of claim6.
 47. A method for controlling the growth of undesired vegetation whichcomprises applying to the locus to be protected an effective amount of acompound of claim
 18. 48. A method for controlling the growth ofundesired vegetation which comprises applying to the locus to beprotected an effective amount of a compound of claim
 19. 49. A methodfor controlling the growth of undesired vegetation which comprisesapplying to the locus to be protected an effective amount of a compoundof claim 20.